A review of sepsis-induced cardiomyopathy

Sato, Ryota; Nasu, Michitaka

doi:10.1186/s40560-015-0112-5

Cited by 236 publications

(256 citation statements)

References 65 publications

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“…Recently, it has been suggested that phosphodiesterase III inhibitors may also be useful for septic cardiomyopathy 1, 2. Our patients did not respond well to conventional therapy.…”

Section: Discussioncontrasting

confidence: 60%

“…As a result, ECG shows LV dysfunction and dilatation without regional dysfunction. These findings are useful to describe the difference from ischemic cardiac failure 1, 2. In sepsis, both the peripheral oxygen requirement and cardiac output are generally increased.…”

Section: Discussionmentioning

confidence: 97%

“…Most patients improve with conventional therapy after 7–10 days1. The rate of septic cardiomyopathy is 18–65% among patients with sepsis and the mortality rate is 36–55% 2…”

Section: Introductionmentioning

confidence: 99%

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Two cases with intra‐aortic balloon pumping use for severe septic cardiomyopathy

Hiromi

Toida

Muguruma

et al. 2017

Acute Medicine & Surgery

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CasesSeptic cardiomyopathy is defined as a reversible left ventricular systolic dysfunction. Patients with severe septic cardiomyopathy have a high mortality rate, even if they receive conventional therapy. For those patients, previous reports showed intra‐aortic balloon pump (IABP) efficacy. We report two rare cases with IABP introduction leading them to drastic improvement, and survival from severe septic cardiomyopathy. Case 1 is a 78‐year‐old woman diagnosed with renal calculus pyelonephritis, septic shock, and septic cardiomyopathy. Case 2 is a 62‐year‐old man diagnosed with pneumonia, septic shock, and septic cardiomyopathy.OutcomeIn both cases, despite conventional therapy for cardiomyopathy, including high‐dose catecholamine therapy, shock was not reversed, and the IABP was inserted. Circulatory status was improved after the introduction of the IABP.ConclusionOur findings suggest that an IABP can be useful for salvaging patients with septic cardiomyopathy who do not respond to conventional therapy.

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“…Recently, it has been suggested that phosphodiesterase III inhibitors may also be useful for septic cardiomyopathy 1, 2. Our patients did not respond well to conventional therapy.…”

Section: Discussioncontrasting

confidence: 60%

Section: Discussionmentioning

confidence: 97%

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Two cases with intra‐aortic balloon pumping use for severe septic cardiomyopathy

Hiromi

Toida

Muguruma

et al. 2017

Acute Medicine & Surgery

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“…Exotoxins like streptolysin O [23] or pneumolysin with cardiotoxic potential cause septic cardiomyopathy leading to arrhythmias [24]. In pneumoccal infections, platelet-activating factor receptor activation by the bacterial cell wall plays the same role [25].…”

Section: Arrhythmias In Septic States -Causative Factorsmentioning

confidence: 99%

Management of arrhythmia in sepsis and septic shock

Borggrefe¹,

Matoušek²,

Malý³

et al. 2017

Anaesthesiol Intensive Ther

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The occurrence of supraventricular arrhythmias is associated with an unfavourable prognosis in septic shock. Available trials are difficult to apply in sepsis and septic shock patients due to included cohorts, control groups and because "one size does not fit all". The priorities in the critically ill are maintenance of the sinus rhythm and diastolic ventricular filling. The rate control modality should be reserved for chronic AF and in situations when the sinus rhythm is difficult to maintain due to extreme stress conditions resulting from a high dosage of vasoactive agents. Electric cardioversion is indicated in unstable patients with an absence of contraindications and is more feasible in combination with an antiarrhythmic agent. Besides amiodarone being preferred for its lower cardiodepressant side effect compared to other agents, drugs with a different degree of betablocking activity are very useful in supraventricular arrhythmias and septic shock, providing echocardiography is routinely used to support their indications within the current summary of product characteristics. A typical patient benefiting from propafenone is without significant structural heart disease, i.e. typically with normal to moderately reduced left ventricular systolic function. Future research should be channelled towards echocardiography-guided prospective controlled trials on antiarrhythmic therapy which may clarify the issue of rhythm versus rate control, the effects of various antiarrhythmic drugs, and a place for electric cardioversion in critically ill patients in septic shock.

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“…The myocardium is functionally and structurally injured by inflammatory cytokines and mitochondrial dysfunction [10]. It has a classical triad: affecting both ventricles and causing global ventricular dysfunction (decreasing biventricular ejection fraction), left ventricular dilatation (diastolic dysfunction with elevated left ventricular end-diastolic volume), and recovery in 7-10 days.…”

Section: Specific Reversible Cardiomyopathiesmentioning

confidence: 99%

Introductory Chapter: Last Crossroad

Kırali¹

2017

Cardiomyopathies - Types and Treatments

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A review of sepsis-induced cardiomyopathy

Cited by 236 publications

References 65 publications

Two cases with intra‐aortic balloon pumping use for severe septic cardiomyopathy

Two cases with intra‐aortic balloon pumping use for severe septic cardiomyopathy

Management of arrhythmia in sepsis and septic shock

Introductory Chapter: Last Crossroad

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