A review of semicarbazone-derived metal complexes for application in biomedicine and related fields

Crystallographic Structure and Quantum-Chemical Analysis of Biologically Active Co(III)-Pyridoxal–Isothiosemicarbazone Complex

“…The complexes have shown promising antitumor, antiviral, and inflammatory activities, in some cases higher than that of cisplatin [15]. Their pote use as materials for electrocatalytic hydrogen evolution has also been proven [16] second largest group of PLITSC-containing compounds has iron as a central metal io in Fe(PLITSC)Cl3 × H2O, Fe(PLITSC)(PLITSC-H)](NO3)2 × H2O, [Fe(PLITSC)(PLIT H)]SO4 × 2H2O [14], Fe(PLITSC)Cl3 × H2O, Fe(PLITSC)(PLITSC-H)](NO3)2 × H2O, [Fe(PLITSC)(PLITSC-H)]SO4 × 2H2O [9]. Cobalt, nickel, and other metal ions also e coordinate with the mentioned ligand, some examples are Co(PLITSC-2H)(PLITSC-CH3OH [17];…”

“…Inorganics 2023, 11, x FOR PEER REVIEW 2 of 16 [7,8]. From the beginning, these ligands seemed promising in terms of their ability to coordinate transition metal ions and their practical application as complexes with biological and catalytic activity [9]. Thus far, many papers in this field have been published describing the biological activities and catalytic abilities of numerous complexes with pyridoxal-semi-carbazone (PLSC) and pyridoxal-S-methyl-iso-thiosemi-carbazone (PLITSC) ligands.…”

“…Later, in the 1980s, Italian chemists in Prof. Pelizzi's group introduced a group of ligands based on pyridoxal-carbazone [7,8]. From the beginning, these ligands seemed promising in terms of their ability to coordinate transition metal ions and their practical application as complexes with biological and catalytic activity [9].…”

The synthesis and structural properties of a chloridobis{N-[(4-methoxyphenyl)imino]pyrrolidine-1-carboxamide}zinc(II) (acetonitrile)trichloridozincate coordination complex

“…Herein is presented pyrrolidinyl-4-methoxyphenylazoformamide, an arylazoformamide (AAF), acting as a ligand through its 1,3-heterodiene N N-C O motif to form a coordination complex with a zinc(II) metal atom. AAFs belong to the semicarbazone ligand family and there have been numerous reports and reviews of their use as ligands (Casas et al, 2000;Mir et al, 2024;Padhye ´& Kauffman, 1985). Semicarbazones and thiosemicarbazones have the capability to coordinate with late transition metals (e.g.…”

Synthesis of an Aryl-Semicarbazone-Based Cu(II) Complex for DNA and BSA Interaction and Anti-Cancer Activity against Human Cervix Uteri Carcinoma

“…For instance, semicarbazone is an important pharmacophore in the search for new drugs [9,11]. The transition metal complexes with semicarbazone exhibit significant biological activity as the ligand, semicarbazone, itself has huge potential to act as a biologically 2 of 15 active reagent [12].…”