A review of seasonality of cleft births – The Brazil experience

Aquino, Sibele Nascimento de; Machado, Renato Assis; Paranaíba, Lívia Máris Ribeiro; Martelli, Daniella Reis Barbosa; Popoff, Daniela Araújo Veloso; Swerts, Mário Sérgio Oliveira; Martelli‐Júnior, Hercílio

doi:10.1016/j.jobcr.2016.03.002

Cited by 4 publications

(13 citation statements)

References 24 publications

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“…However, patients still seem to have concerns about their facial appearance, especially related to the cleft deformity. The self-perceived improvement in facial appearance following treatment had a strong positive influence on quality of life and patient satisfaction compared to other functional or treatment-related factors [1][2][3].…”

Section: Cleft Lip/palate: General Considerationsmentioning

confidence: 92%

“…Cleft lip/palate (CL/P) are among the most common birth defects around the world with a prevalence of 1.43:1000 live births. Other studies have shown that the frequency is approximately 1 in 600/700 live births and correction involves prolonged treatment over many years [1,2].…”

Section: Cleft Lip/palate: General Considerationsmentioning

confidence: 99%

“…The multifactorial threshold model is one of the well-established models for describing the etiology of CL/P, in which statements, the malformations result from factors such as genetic predisposition and exogenous factors like maternal malnutrition, low intake of folic acid, teratogens including drugs and alcohol, viruses, and maternal age [1].…”

Section: Cleft Lip/palate: General Considerationsmentioning

confidence: 99%

“…Other studies considerated seasonal influence [1] and they considered that it was reasonable to expect the orofacial clefts may show seasonal variations due to indirect factors such as: maternal malnutrition and low intake of folic acid, and other direct factors such as temperature, intensity of ultraviolet light exposure, use of fertilizers and pesticides in agriculture, and infectious disease cycles.…”

Section: Cleft Lip/palate: General Considerationsmentioning

confidence: 99%

“…In Brazil [1] and part of Latin-American community, epidemiological studies demonstrated that incidence of CL/P episodes varies from 0.19 to 1.4/1000 births. Approximately 65-70% of cleft lip with or without cleft palate (CLP) and 40-70% of cleft palate only (CP) were isolated defects and the remaining related to syndromic clefts.…”

Section: Epidemiological Profile In Brazilian and Latin-american Commmentioning

confidence: 99%

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Surgical Approach of Cleft Lip/Palate Patients: The Brazilian Experience

Moreira¹,

Bernaola-Paredes²

2020

Maxillofacial Surgery and Craniofacial Deformity - Practices and Updates

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Cleft lip/palate (CL/P) are among the most common birth defects around the world with a prevalence of 1.43:1000 live births. Other studies have shown that the frequency is approximately 1 in 600/700 live births and correction involves prolonged treatment over many years. A variety of surgical techniques and modifications have been described regarding cleft lip and palate (CLP) treatment 2. However, patients still seem to have concerns about their facial appearance, especially related to the cleft deformity. The self-perceived improvement in facial appearance following treatment had a strong positive influence on quality of life and patient satisfaction compared to other functional or treatment-related factors. Depending on the cleft type and severity, as well as treatment outcome, important functions like eating, speech, appearance, and maxillary growth may be impaired. This can affect patients social-emotional functioning and self-esteem resulting in a lower health-related quality of life.

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Section: Cleft Lip/palate: General Considerationsmentioning

confidence: 92%

Section: Cleft Lip/palate: General Considerationsmentioning

confidence: 99%

Section: Cleft Lip/palate: General Considerationsmentioning

confidence: 99%

Section: Cleft Lip/palate: General Considerationsmentioning

confidence: 99%

Section: Epidemiological Profile In Brazilian and Latin-american Commmentioning

confidence: 99%

See 3 more Smart Citations

Surgical Approach of Cleft Lip/Palate Patients: The Brazilian Experience

Moreira¹,

Bernaola-Paredes²

2020

Maxillofacial Surgery and Craniofacial Deformity - Practices and Updates

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Distribution and risk factors of cleft lip and palate on patients from a sample of Damascus hospitals - A case-control study

Nahas

Alzamel

Dali

et al. 2021

Heliyon

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This case-control study was conducted to determine the distribution of cleft lip and/or palate, its association with family history, syndromes and serous otitis media (SOM), and its relation with several risk factors. Methods: The case group comprised of 133 children born with cleft lip and/or palate, and the control was 133 noncleft children born full-term. Data was collected including age, gender, origin and risk factors for cleft lip and palate from patients' files, interviewing supervising doctors, and the patient. Data was then filled out into Excel and underwent statistical analysis using the Goodness of Fit Test and Chi-Square to determine the significance of the results. Results: Cleft lip and/or palate (CL/P) was slightly higher among males (51.9%). Combined cleft lip and palate (CLP) was the most common presentation (42.1%). Cleft lips (CL) were mostly complete cleft (51,5%) incomplete cleft comprised (41.1%), In the sample 35.4% of the cases were bilateral, 32.3% were right unilateral, 28.3% were left unilateral and 4% were median cleft. Cleft palate (CP) was mostly complete (46.6%) there were incomplete clefts (40%), and the remainder were submucosal (13.4%). Isolated CL and combined CLP were higher in males (51.6%, 62.5% respectively). Both isolated CP and Tessier anomaly were more common in females (64.7% and 58.3% respectively). consanguineous marriages accounted for 36.1% of cases. 21.8% of the sample had a firstdegree relative and 24.8% had a second degree relative born with CL/P. There were only 7 cases (0.05%) of syndromic CL/P: Down's (4), Pierre Robin's (2), and Van der Woude Syndrome (1). A relationship was found between CL/P and the risk factors: taking anticonvulsants (without specifying the drug) (p ¼ 0.025, OR ¼ 10.73 C.I. 95%), taking retinoic acid (p-value ¼ 0.049, OR ¼ 4.75 C.I. 95%), not consuming folic acid (p-value ¼ 0.00, OR ¼ 28.23 C.I. 95%), and smoking cigarettes (p-value ¼ 0.046, OR ¼ 2.00 C.I. 95%). There was no relationship with maternal alcohol consumption or maternal diabetes (p-values ¼ 0.652 and 0.210, respectively). SOM was present in 63.2% of patients with CL/P and were mostly isolated CP. Conclusion: CL/P was only slightly higher among males. The most common condition was CLP. There was higher incidence of CL/P among second-degree relatives than first degree. Down's, Pierre Robin's, and Van der Woude Syndromes may be associated with CL/P. Taking anticonvulsants, taking retinoic acid, not consuming folic acid, and smoking cigarettes all have a role in the incidence of CL/P. More than half of the sample had an associated SOM.

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Epidemiological and Spatiotemporal Descriptive Analysis of Patients with Nonsyndromic Cleft Lip and/or Palate: A 12‐Year Retrospective Study in Southern Iran

Farshidfar

Ajami

Sahmeddini

et al. 2023

BioMed Research International

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Objectives. The current study is aimed at evaluating epidemiological characteristics and spatiotemporal distribution of cleft lip and/or palate (CL/P) in the south of Iran. Methods. Data were extracted from the 1840 medical records of patients who were referred to the Cleft Lip and Palate Center of Shiraz University of Medical Sciences, from January 1, 2011, to September 1, 2022. The collected variables included demographic data (gender, birth date and season, place, birth order, and weight), cleft types and the subtypes, parental information (health status, education level, marital status, and age during the pregnancy), and other basic parameters. The chi-square test at a significance level of 0.05 was used to analyze collected data. The geographic information system (GIS) analysis was also used for analyzing the spatial distribution of CL/P patients. Results. Based on our inclusion criteria, 1281 nonsyndromic patients were included in this study. The most common type was cleft lip and palate (CLP) with 48.32%, whereas cleft palate (CP) and cleft lip (CL) accounted for 40.75% and 10.93% of the patients, respectively. There was a progressive increase in the frequency of all types of clefts, and most of them were male ( P ≤ 0.001 ). The urban population outnumbered the rural ones in all provinces. Parents were mostly healthy (>80%) with low educational status (47.5%). Most born CL/P patients were from consanguineous marriages (58.9%), especially between first-degree relatives. A majority of CL/P patients (73.1%) were born in the first two gestations with a birth weight of 2500-4000 g (77.4%). Most infants with CL/P (84.3%) were born from mothers who had at least one of the predisposing factors. Conclusion. In this study, the frequency of cleft types and subtypes was similar to the existing literature. However, high rate of consanguineous marriage, especially between first-degree relatives, was the most notable feature of this population.

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A review of seasonality of cleft births – The Brazil experience

Cited by 4 publications

References 24 publications

Surgical Approach of Cleft Lip/Palate Patients: The Brazilian Experience

Surgical Approach of Cleft Lip/Palate Patients: The Brazilian Experience

Distribution and risk factors of cleft lip and palate on patients from a sample of Damascus hospitals - A case-control study

Epidemiological and Spatiotemporal Descriptive Analysis of Patients with Nonsyndromic Cleft Lip and/or Palate: A 12‐Year Retrospective Study in Southern Iran

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