A Review of Saurauia roxburghii Wall. (Actinidiacaea) as a Traditional Medicinal Plant, Its Phytochemical Study and Therapeutic Potential

Nahrin, Afsana; Junaid, Md.; Afrose, Syeda Samira; Alam, Muhammad Shaiful; Hosen, S. M. Zahid; Akter, Rasheda; Sharmin, Tania

doi:10.2174/1389557520666200709175138

Cited by 3 publications

(2 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is used as an active ingredient in many medicinal plants, vegetables and nuts [ 1 ]. Structurally, it is similar to animal sterols [ 2 ]. It is widely applied in pharmaceutical, food and cosmetic industries due its proven pharmacological effects, including anti-inflammatory and anti-allergic, immunomodulatory effects [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Stigmasterol alleviates airway inflammation in OVA-induced asthmatic mice via inhibiting the TGF-β1/Smad2 and IL-17A signaling pathways

Huang,

Zhou,

Yuan

et al. 2024

Aging

View full text Add to dashboard Cite

Stigmasterol is a common dietary phytosterol with high nutritional value and physiological activity. In this study, we evaluated the effects of stigmasterol on inflammatory cytokines and the TGF-β1/Smad2 and IL-17A signaling pathway in an ovalbumin (OVA)-induced asthma mouse model. Stigmasterol treatment improved airway remodeling. In addition, it significantly attenuated the symptoms of asthma attacks, reduced the number of macrophages, lymphocytes, neutrophils, and eosinophils in BALF and inflammatory cytokines, including IL-1β, IL-5, IL-6, and IL-13. It further decreased the level of IL-17A in BALF, serum and spleen. Spleen single-cell suspension analysis via flow cytometry showed that IL-17A level was consistent with the results obtained in BALF, serum and spleen. Stigmasterol decreased the protein expression levels of TGF-β, p-Smad2 and IL-17A in the spleen, by increasing the protein expression level of IL-10. After 24 h of co-culture of TGF-β, IL-6 and stigmasterol, the level of IL-17 in CD4 + T cell supernatant was lower relative to levels in the group without stigmasterol. Meanwhile, stigmasterol treatment attenuated the expression level of TGF- β, p-Smad2 and IL-17A proteins in CD4 + T cells and enhanced the expression levels of IL-10 protein. These data suggested that stigmasterol inhibited the TGF-β1/Smad2 and IL-17A signaling pathway to achieve anti-asthmatic effects in the OVA-induced asthma mouse model. Collectively, the results of this study are that stigmasterol has achieved preliminary efficacy in the non-clinical laboratory, further studies are needed to consider the clinical application of stigmasterol.

show abstract

Section: Introductionmentioning

confidence: 99%

Stigmasterol alleviates airway inflammation in OVA-induced asthmatic mice via inhibiting the TGF-β1/Smad2 and IL-17A signaling pathways

Huang,

Zhou,

Yuan

et al. 2024

Aging

View full text Add to dashboard Cite

show abstract

“…Whereas flaxseed is also rich in antioxidants and oil, which contains linoleic and linolenic acids about 35-40% and 20-25% proteins, the seed contains cyanogenic glycosides as a bioactive compound which have potent pharmacological actions such as stimulating respiration, cardioprotective effects, anti-cancer effects, management of diabetes 7,8 .…”

Section: Introductionmentioning

confidence: 99%

Untitled

2021

IJPSR

View full text Add to dashboard Cite

Berries, fruits, and flaxseed have nowadays have increased in research studies. The berries such as Rubus idaeus (Red raspberry), Vaccinium macrocarpon (cranberry), Vaccinium angustifolium (blueberry) and Fragaria x ananassa Duch. (strawberry) have health beneficial compounds like anthocyanins, ellagitannins, ellagic acids, polyphenolic compounds and whereas in flaxseed the polyunsaturated fatty acids (PUFAs), α-linolenic acid, omega-3 fatty acids have a potential effect on health. This study aims to evaluate for standardization of polyherbal extract obtained from berries and flaxseed by qualitative phytochemical analysis, physicochemical analysis, Fourier transform infrared spectroscopy, UV analysis, thin layer chromatography. The maceration method is used for performing the extraction and plant-based edible polymer Acrypol 934 P for the preparation of the polyherbal ethyl acetate extract and its gel-based formulation. Different phytochemical tests and physicochemical evaluation procedures were followed for standardization of extract and afterwards gel formulation. The results confirmed the presence of various phytochemicals including flavonoids (rich in content in each), tannins, saponins, cardiac glycosides, phenolics. Different physicochemical studies including viscosity are some extent change due to gelation at room temperature, FTIR characterizes the presence of a particular functional group in the extract. Thinlayer chromato-graphy for the analysis of flavonoids with respective Rf value is determined. The study concludes that the berries and flaxseed have a potential effect on health benefits and they have a high range of flavonoids by phytochemical screening and stability studies are slight change due to conditions of climatic changes at room temperature.

show abstract

Nyctanthes arbor-tristis Linn.: A Review on its Traditional Uses, Phytochemistry, Pharmacological Activities, and Toxicity

Barua

Junaid

Shamsuddin

et al. 2023

CTM

View full text Add to dashboard Cite

Background: Nyctanthes arbor-tristis Linn. (Oleaceae) is a traditional therapeutic plant, highly used in Ayurveda for a wide range of activities, such as anthelmintic, antipyretic, laxative, rheumatism, skin ailments, and sedative. Aims of the review: This review aims to furnish up-to-date details on botanical characterization, geographical distribution, traditional uses, phytochemical constituents, pharmacological activities, and toxicity of Nyctanthes arbor-tristis Linn. with the exploitation of future research on more curative treatments as well. Methods: The available information was reviewed using different e-tools, including PubMed (National Library of Medicine), ScienceDirect, Wiley, Elsevier, Springer. The scientific name is verified from 'The Plant 'List' (www.theplantlist.org) and 'Kew Royal Botanic 'Gardens' (mpns.kew.org). Results: Crude extracts and isolated compounds of Nyctanthes arbor-tristis Linn. have been found pharmacologically active as hepatoprotective, anti-leishmaniasis, antiviral, antifungal, antipyretic, antihistaminic, antimalarial, antibacterial, anti-inflammatory, antioxidant activities it was widely for intermittent fevers and arthritis treatment. The major classes of biologically active compounds are their iridoid, glucosides, essential oils, hydrocarbons, alkaloids, benzofurans, cyclohexylethanoid, fatty acids, sterols, and terpenoid. Conclusions: Phytochemical studies and Nyctanthes arbour-tristis Linn's pharmacological activities indicated it as a potential medicinal plant for various ailments. However, more research is crucial to investigate the mode of action of the plant's bioactive constituents and its therapeutic potential.

show abstract

A Review of Saurauia roxburghii Wall. (Actinidiacaea) as a Traditional Medicinal Plant, Its Phytochemical Study and Therapeutic Potential

Cited by 3 publications

References 16 publications

Stigmasterol alleviates airway inflammation in OVA-induced asthmatic mice via inhibiting the TGF-β1/Smad2 and IL-17A signaling pathways

Stigmasterol alleviates airway inflammation in OVA-induced asthmatic mice via inhibiting the TGF-β1/Smad2 and IL-17A signaling pathways

Untitled

Nyctanthes arbor-tristis Linn.: A Review on its Traditional Uses, Phytochemistry, Pharmacological Activities, and Toxicity

Contact Info

Product

Resources

About