A Review of Risk Factors for Methamphetamine-Related Psychiatric Symptoms

Chang, Xiaoxia; Sun, Yan; Zhang, Yang; Muhai, Jia-Na; Lü, Lin; Shi, Jie

doi:10.3389/fpsyt.2018.00603

Cited by 19 publications

(22 citation statements)

References 85 publications

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“…Chronic abuse of methamphetamine contributes to anxiety, depression, aggressiveness, social isolation, psychosis, mood disturbances, and psychomotor dysfunction [28,33,51,52]. One interesting aspect of chronic methamphetamine psychosis is the complaint of ants or other bugs crawling in the chronic methamphetamine users' skin.…”

Section: Chronic Psychiatric Effects Of Methamphetaminementioning

confidence: 99%

Psychostimulant use disorder emphasizing methamphetamine and the opioid -dopamine connection: Digging out of a hypodopaminergic ditch

Blum

Cadet

Gold

2021

Journal of the Neurological Sciences

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Background: Approved food and drug administration (FDA) medications to treat Psychostimulant Use Disorder (PUD) are needed. Both acute and chronic neurological deficits related to the neurophysiological effects of these powerfully addictive drugs can cause stroke and alterations in mood and cognition. Objective: This article presents a brief review of the psychiatric and neurobiological sequelae of methamphetamine use disorder, some known neurogenetic associations impacted by psychostimulants, and explores treatment modalities and outcomes. Hypothesis: The authors propose that gentle D2 receptor stimulation accomplished via some treatment modalities can induce dopamine release, causing alteration of D2-directed mRNA and thus enhanced function of D2 receptors in the human. This proliferation of D2 receptors, in turn, will induce the attenuation of craving behavior, especially in genetically compromised high-risk populations. Discussion: A better understanding of the involvement of molecular neurogenetic opioid, mesolimbic dopamine, and psychostimulant connections in "wanting" supports this hypothesis. While both scientific and, clinical professionals search for an FDA approved treatment for PUD the induction of dopamine homeostasis, via activation of the brain reward circuitry, offers treatment for underlying neurotransmitter functional deficits, potential prophylaxis, and support for recovery efforts. Conclusion: Dopamine regulation may help people dig out of their hypodopaminergia ditch.

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Section: Chronic Psychiatric Effects Of Methamphetaminementioning

confidence: 99%

Psychostimulant use disorder emphasizing methamphetamine and the opioid -dopamine connection: Digging out of a hypodopaminergic ditch

Blum

Cadet

Gold

2021

Journal of the Neurological Sciences

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“…Methamphetamine psychosis is one of the most common, most debilitating, and most dangerous symptoms associated with methamphetamine use [2,[6][7][8]. Research has found that about 40% of methamphetamine users will experience psychosis [2].…”

Section: Methamphetamine Psychosismentioning

confidence: 99%

“…DOI: https://dx.doi.org/10.17352/2455-3484.000042 stated above. Chang, et al (2018) [6] found that adverse life events and poly-drug use, especially the use of synthetic drugs such as ketamine, increased a methamphetamine user's risk for developing psychosis.…”

Section: Methamphetamine Psychosismentioning

confidence: 99%

Methamphetamine-Related Psychiatric Symptoms with Special Reference to COVID-19 Issues

Msw¹,

Wellisch²

2020

J Addict Med Ther Sci

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General psychological and physiobiological issues Methamphetamine is a highly addictive stimulant drug that effects the user's central nervous system. The drug enters the brain very quickly, making the substance faster-acting and more addictive than other stimulants. Methamphetamine use is associated with a plethora of both physical and psychological symptoms. Notably, the psychological symptoms related to methamphetamine use can resemble the symptoms of mental health conditions such as schizophrenia and bipolar disorder. These symptoms include psychosis, hallucinations, delusions, insomnia, irritability, and mood disturbances [1-3]. Methamphetamine withdrawal is accompanied by its own set of associated symptoms, including hostility, hypersomnia, aggression, fatigue, depression, and anhedonia [1,4]. The intensity of these withdrawal symptoms tends to increase as the severity and chronicity of methamphetamine use increases [4]. Research has found that psychiatric symptoms among methamphetamine users are 11 times higher than the symptoms reported by the general public [5]. The presence of psychotic symptoms in methamphetamine users is related to a number of factors including frequency of use, chronicity of use, dosage amount, and the route of administration (i.e. whether it is smoked, snorted, taken intravenously, or ingested) [8,10,11]. Research by Su, et al. (2018) [8] identifi ed personal characteristics such as high impulsivity, previous heroin and tobacco use, and comorbid symptoms of depression and anxiety as risk factors for methamphetamine psychosis, in addition to the risk factors

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“…This effect may also be attributable to generally better effects anti-seizure medicines commonly used in this protocol have in controlling depressive symptoms. This may be so because depressive symptoms closely resemble "negative symptoms" of psychosis and could be reduced by introduction of anti-seizure medicines [11].…”

Section: Interestingly Psychiatric Interventions With Persons Whose Psychosis Is Believed To Have Been Induced By Chronic Use Ofmentioning

confidence: 99%

Ideographic Distinctions Between Methamphetamine Induced Persistent Psychosis and Schizophrenic Disorders: A Qualitative Clinical Analysis Toward Differential Diagnosis

Tzachor¹

2019

OAJAP

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though, the co-morbidity rates of Schizophrenia with substancerelated disorders are also high, leading to potential problems with differential diagnosis [1].What most professionals also seem to agree upon is that whatever the reason, the most critical elements in the biology of schizophrenic disorders is found in the malfunction of neural communication in the brain. Specifically, the malfunction seems to concentrate primarily in neurons whose communication is facilitated by the chemical neurotransmitter called Dopamine. While nerves that utilize Dopamine are involved in many cortical and sub-cortical mental activities, they seem to concentrate in communication of thinking, sensory, motor, and emotional mental processes. The malfunction of Dopamine nerve communication in schizophrenics appears to be rooted in the development of over-zealous activity of neurons which utilize Dopamine. This development in-turn, results in sensory, mental, and emotional activity which largely exceeds normal human experience [2,5].

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A Review of Risk Factors for Methamphetamine-Related Psychiatric Symptoms

Cited by 19 publications

References 85 publications

Psychostimulant use disorder emphasizing methamphetamine and the opioid -dopamine connection: Digging out of a hypodopaminergic ditch

Psychostimulant use disorder emphasizing methamphetamine and the opioid -dopamine connection: Digging out of a hypodopaminergic ditch

Methamphetamine-Related Psychiatric Symptoms with Special Reference to COVID-19 Issues

Ideographic Distinctions Between Methamphetamine Induced Persistent Psychosis and Schizophrenic Disorders: A Qualitative Clinical Analysis Toward Differential Diagnosis

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