A review of Risk Factors for Post-traumatic hip and knee osteoarthritis following musculoskeletal injuries other than anterior cruciate ligament rupture.

Castaño-Betancourt, Martha C.; Maia, Catrine Rangel; Munhoz, Marcelo de Azevedo e Souza; Morais, Caroline Larissa; Machado, Eduardo Gomez

doi:10.52965/001c.38747

Cited by 8 publications

(10 citation statements)

References 139 publications

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“…Castano Betancourt и соавт. [20] провели метаанализ 122 исследований, в которых анализируются факторы риска ПТОА. Было показано, что наличие серьезного повреждения мениска повышает вероятность развития данной патологии почти в 8 раз (отношение шансов, ОШ 7,9; 95% ДИ 4,4-14).…”

Section: факторы рискаunclassified

Post-traumatic osteoarthritis: epidemiology, pathogenesis, clinical picture, approaches to pharmacotherapy

Karateev¹,

Chernikova²,

Макаров³

2023

Sovremennaâ revmatologiâ

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Post-traumatic osteoarthritis (PTOA) is an inflammatory and degenerative disease that occurs as a result of the joint structures injury. It is a common pathology, accounting for approximately 12% of all cases of osteoarthritis (OA). PTOA often occurs in people of young productive age, progresses rapidly, causing chronic pain and increasing dysfunction. Individuals undergoing joint replacement for PTOA are, on average, 10 years younger than those with primary OA. The time interval from the moment of injury to the onset of typical PTOA radiological signs varies widely – from 1 year to 15–20 years.The main injuries that cause PTOA are intra-articular fractures, anterior cruciate ligament injuries, meniscus rupture and dislocation of the patella of the knee joint, joint dislocations with damage to the ligamentous apparatus of the ankle and shoulder joints.The pathogenesis of PTOA is determined by chronic inflammation accompanied by macrophage activation, hyperproduction of cytokines, primarily interleukin (IL) 1â, chemokines and growth factors, progressive destruction of joint tissue and degenerative changes (fibrosis, neoangiogenesis, osteophytosis).Pathogenetic treatment of PTOA, which would stop the progression of the disease, has not been developed. The possibility of using inhibitors of IL1â, IL6, inhibitors of tumor necrosis factor á, glucocorticoids, hyaluronic acid, autologous cell based therapy is under study. The control of pain and inflammation in PTOA requires the prescription of traditional drugs that are widely used in the practice of managing patients with primary OA. In particular, the use of symptomatic delayed-acting agents, such as the injectable form of chondroitin sulfate, seems to be appropriate.

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Section: факторы рискаunclassified

Post-traumatic osteoarthritis: epidemiology, pathogenesis, clinical picture, approaches to pharmacotherapy

Karateev¹,

Chernikova²,

Макаров³

2023

Sovremennaâ revmatologiâ

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“…Beyond subsequent injury, acute injury also results in a potential low return to general physical fitness activity 7 and in the case of athletes, a reduction in competitive physical activity 8 . Finally, in many cases of acute musculoskeletal injury, a high incidence of post traumatic osteoarthritis persists 9–11 . Collectively, these data suggest a significant gap in our current model of care for patients with acute musculoskeletal injury exists as it results in a return to less active lifestyles, with increased risk for future injury and long‐term chronic pathology.…”

Section: Introductionmentioning

confidence: 99%

“…8 Finally, in many cases of acute musculoskeletal injury, a high incidence of post traumatic osteoarthritis persists. [9][10][11] Collectively, these data suggest a significant gap in our current model of care for patients with acute musculoskeletal injury exists as it results in a return to less active lifestyles, with increased risk for future injury and long-term chronic pathology.…”

Section: Introductionmentioning

confidence: 99%

Booster visits in the management of the acute musculoskeletal injuries: Transforming care to improve outcomes–A perspective review

Paterno,

Fitzgerald

2024

Journal Orthopaedic Research

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The current healthcare delivery system for patients with acute musculoskeletal injury is failing. Current rehabilitation management of acute musculoskeletal injury typically includes physical therapy, focused on management of impairments, with an eventual transition to functional activities and release to prior level of function. At that point, formal physical therapy is often discontinued, despite the knowledge that a high percentage of patients fail to maintain preinjury level of activity and often reduce participation in regular physical activity. Further, for those who attempt to return to prior levels of pivoting and cutting activities, there is a high second injury rate. The long‐term human experience is compromised by the current model of care which terminates at the point of transition to activity. This model of care fails to meet the continued needs of these patients and may result in long term deficits and potential disability. Extended care models include intermittent follow up visits after discharge from an acute episode of care and have been efficacious and cost effective in some patient populations with musculoskeletal conditions. Specifically, a type of extended care model, labeled “booster sessions,” represents an opportunity to provide structured, intermittent care to assist in a smooth transition back to function, following an acute episode of care and promote a healthier life outcome. This perspective review will discuss the opportunity to transform acute musculoskeletal care to booster visit care model in an attempt to develop a more efficacious and cost‐effective system of care which could be generalizable to all musculoskeletal conditions.

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“…2 Other risk factors of developing PTOAK include age, obesity, female sex, joint malalignment, and genetics. 3 Osteoarthritis significantly reduces patient health-related quality of life, 4 and, moreover, PTOAK treatment costs place a substantial economic strain on the US healthcare system. 5…”

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confidence: 99%

“…2 Other risk factors of developing PTOAK include age, obesity, female sex, joint malalignment, and genetics. 3 Osteoarthritis significantly reduces patient healthrelated quality of life, 4 and, moreover, PTOAK treatment costs place a substantial economic strain on the US healthcare system. 5 The reported occurrence of PTOAK is highly variable, ranging from zero to 39% in isolated ACL injuries and 21% to 100% in combined ACL/meniscal injuries.…”

mentioning

confidence: 99%

The Epidemiology of Posttraumatic Osteoarthritis of the Knee in the United States: An Analysis of 948,853 Patients From 2000 to 2022

Bank,

Sanghvi,

Hecht

et al. 2024

J Am Acad Orthop Surg

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Introduction: Posttraumatic osteoarthritis of the knee (PTOAK) is a known sequela of bony and soft-tissue articular knee injuries, although its historically reported prevalence is highly variable with no recent population-based studies. Methods: The TriNetX/US Collaborative Network database was queried to identify adult patients diagnosed with a history of knee trauma using ICD-10-CM coding. Primary outcomes measured were yearly incidence proportion (IP), incidence rate (IR), and prevalence of knee osteoarthritis in the United States from 2000 to 2022. Chi square analyses were conducted to compare outcomes across categorical data. Regression modeling was performed to project PTOAK epidemiology to 2030. Statistical significance was held at P < 0.05 for all analyses. Results: Nine hundred forty-eight thousand eight hundred fifty-three patients meeting criteria were identified. As of 2022, the IP of PTOAK was 5.93%, IR was 2.26 × 10−4 cases/person-day, and prevalence was 21.1%. By strata in 2022, posttraumatic knee OA is most prevalent among the 54 to 59-year-old age group (50.9%), 60 to 64-year-old age group (50.3%), 50 to 54-year-old age group (49.7%), female patients (24.2%), and White patients (23.1%). Regression analyses revealed that the IP, IR, and prevalence of PTOAK have increased exponentially from 2000 to 2022. By 2030, the model predicts that the IP will further increase to 10.7% (95% PI = 9.79% to 11.7%), IR will be 3.79 × 10−4 cases/person-day (95% PI = 3.28 × 10−4 to 4.29 × 10−4), and prevalence of PTOAK in the United States will be 40.6% (95% PI = 39.1% to 42.0%). Discussion: These findings echo earlier, smaller scale studies but reveal an alarming rise in PTOAK prevalence, potentially doubling by 2030. The financial burden of knee OA treatment in the United States is already substantial, costing between $5.7 and $15 billion USD annually. This projected increase in prevalence could further increase healthcare expenditures by $1 to 3 billion by 2030. These results emphasize the need for additional research into factors contributing to PTOAK, evidence-based preventive public health interventions, and the development of multidisciplinary system-based care delivery optimization pathways.

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A review of Risk Factors for Post-traumatic hip and knee osteoarthritis following musculoskeletal injuries other than anterior cruciate ligament rupture.

Cited by 8 publications

References 139 publications

Post-traumatic osteoarthritis: epidemiology, pathogenesis, clinical picture, approaches to pharmacotherapy

Post-traumatic osteoarthritis: epidemiology, pathogenesis, clinical picture, approaches to pharmacotherapy

Booster visits in the management of the acute musculoskeletal injuries: Transforming care to improve outcomes–A perspective review

The Epidemiology of Posttraumatic Osteoarthritis of the Knee in the United States: An Analysis of 948,853 Patients From 2000 to 2022

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