A review of recently published radiotherapy treatment guidelines for bone metastases: Contrasts or convergence?

Lutz, S; Chow, Edward

doi:10.1016/j.jbo.2012.04.002

Cited by 26 publications

(9 citation statements)

References 33 publications

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“…Pain reduction lasts in at least 50% of patients for more than 6 months 68. Current evidence indicates that single-fraction radiotherapy (with at least 6 Gy) is the treatment of choice for quick pain relief 69. However, fractionated radiation leads to more effective remineralization of bone.…”

Section: Systemic Treatment Of Bmsmentioning

confidence: 99%

Current concepts and trends in the treatment of bone metastases in patients with advanced prostate cancer

Hegemann¹,

Maas²,

Rausch³

et al. 2019

Asian J Androl

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Bone metastases have a major impact on quality of life and survival of patients with advanced prostate cancer. In the last decade, the development and approval of substances inhibiting the vicious cycle of bone metastases have enabled the reduction of complications caused by bone metastases in patients with castration-resistant prostate cancer. These drugs have raised awareness of the importance of skeletal-related events which in the meantime represent an important end point also in trials using agents not specifically designed for bone lesions. Second-generation antihormonal drugs such as enzalutamide or abiraterone have been shown to have a positive impact on the incidence of skeletal complications and therefore provide an important tool in the armamentarium used for treating bone metastases. Radiopharmaceuticals such as radium-223 dichloride ([223Ra]) have been demonstrated not only to reduce skeletal-related events and bone-related pain, but also to prolong overall survival, thereby being the first bone-targeting agent showing a survival benefit. As previous studies have not provided an obvious benefit of bone-targeted lesions in castration-sensitive disease, the use of these agents is not recommended. In oligometastatic prostate cancer, the role of local treatment of metastases using stereotactic radiation or radiosurgery is a matter of intense debates and may play an increasing role in the future.

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Section: Systemic Treatment Of Bmsmentioning

confidence: 99%

Current concepts and trends in the treatment of bone metastases in patients with advanced prostate cancer

Hegemann¹,

Maas²,

Rausch³

et al. 2019

Asian J Androl

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“…Radiotherapy provides partial pain relief in 70% patients while complete pain relief may be seen in up to one-third of patients. [4647] Up to one-third of patients may have refractory pain. [48] According to the latest NCCN guidelines concerning adult cancer pain (v2, 2016), percutaneous ablation for metastatic bone pain may be considered when pharmacologic therapy is inadequate and radiation therapy is contraindicated or not desired by the patient in cases without an oncologic emergency (e.g., pathologic fracture or epidural disease).…”

Section: Management Of Complicationsmentioning

confidence: 99%

Complementary role of intervention radiology in palliative care in oncology setting

Dhamija

Deshmukh

Meena

et al. 2019

Indian J Palliat Care

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Owing to advances in treatment of cancer, there has been increase in life expectancy. Palliative care aims at improving quality of life of patients suffering from malignancy and is now recognized as a separate subspecialty. Management of cancer patients needs a multidisciplinary approach, and radiology has a key role to play at every step of it. Interventional radiology has broadened its scope immensely over the last decade with development of newer and less invasive applications useful in oncology and palliative care. The role of interventional radiologists begins from obtaining tissue for histopathological examination and extends to controlling disease spread with ablation or chemoembolization, to managing the tumor-related complications and relieving stressful symptoms such as dyspnea and pain. This article aims to review the interventional radiologist's arsenal in managing patients with malignancies with a special emphasis on palliative care, providing a more holistic approach in improving the quality of life of cancer patients.

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“…Radiotherapy, although used frequently, is reported to provide partial pain relief in 70% of the treated patients while complete pain relief may be seen in up to one-third of the patients. 45,46 The three-step analgesic ladder proposed by WHO seems to provide satisfactory pain management in the vast majority of cancer patients, but nearly one-third of them eventually will complain of refractory pain (which is defined as a nonresponsive type of pain). 47 Additionally, despite its value, the administration of opioids is not without cost; dose and continuous use are factors directly affecting the risk of harm.…”

Section: Curative Intent In Oligometastatic Bone Diseasementioning

confidence: 99%

Metastatic Osseous Pain Control: Bone Ablation and Cementoplasty

Kelekis

Cornelis

Tutton

et al. 2017

Semin intervent Radiol

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Nociceptive and/or neuropathic pain can be present in all phases of cancer (early and metastatic) and are not adequately treated in 56 to 82.3% of patients. In these patients, radiotherapy achieves overall pain responses (complete and partial responses combined) up to 60 and 61%. On the other hand, nowadays, ablation is included in clinical guidelines for bone metastases and the technique is governed by level I evidence. Depending on the location of the lesion in the peripheral skeleton, either the Mirels scoring or the Harrington (alternatively the Levy) grading system can be used for prophylactic fixation recommendation. As minimally invasive treatment options may be considered in patients with poor clinical status or limited life expectancy, the aim of this review is to detail the techniques proposed so far in the literature and to report the results in terms of safety and efficacy of ablation and cementoplasty (with or without fixation) for bone metastases. Percutaneous image-guided treatments appear as an interesting alternative for localized metastatic lesions of the peripheral skeleton.

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A review of recently published radiotherapy treatment guidelines for bone metastases: Contrasts or convergence?

Cited by 26 publications

References 33 publications

Current concepts and trends in the treatment of bone metastases in patients with advanced prostate cancer

Current concepts and trends in the treatment of bone metastases in patients with advanced prostate cancer

Complementary role of intervention radiology in palliative care in oncology setting

Metastatic Osseous Pain Control: Bone Ablation and Cementoplasty

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