A review of recent advances in histopathological assessment of head and neck squamous cell carcinoma

Chegini, Soudeh; Mitsimponas, Konstantinos; Shakib, Kaveh

doi:10.1111/jop.12943

Cited by 6 publications

(1 citation statement)

References 22 publications

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“…The cause of OSCC is like any other cancer; a DNA mutation that often occurs spontaneously but is increased by chemical, physical, and microbial mutagenic agents. [ 3 4 ] Various studies have shown that the epidemiological pattern of oral and lip cancers is changing. Among them, an increase in the prevalence of SCC, especially among young people, has been shown, which is associated with higher tobacco and alcohol use among young people.…”

Section: Introductionmentioning

confidence: 99%

Evaluating the clinicopathologic parameters of tongue squamous cell carcinoma based on its local distribution

2023

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Background: Oral squamous cell carcinoma (OSCC) is one of the most common oral lesions and the tongue is one of the most common areas involved. The aim of this study was to evaluate the clinicopathologic feature of tongue SCCs based on its local distribution. Materials and Methods: In this cross-sectional study, clinical data such as age, gender, location, and clinical appearance were extracted from the archives of the Oral Pathology Department, Isfahan Dental School, registered with a definitive diagnosis of tongue SCC during 2005-2019. Then, 34 specimens were selected for histopathological evaluation in a simple random way. The histopathologic slides were examined to determine the grade of tumor malignancy. The data were entered into SPSS23 software and analyzed by Chi-square, Fisher exact, One-way ANOVA, and Non-parametric tests. P value <0.05 was considered significant. Results: Of the 275 OSCCs, 68 samples were tongue SCC. The mean age of patients was 61.7 ± 15 and 61.8% were women. The most common clinical manifestations were exophytic lesions (42.6%) and the most common site was the lateral border of the tongue (36.8%). The results did not show a significant relationship between the clinicopathologic feature including mean age (p = 0.766), gender (p = 0.338), clinical presentation (p = 0.434), grade of malignancy (p = 0.763) and location. But, among the histopathological parameters, the pattern of invasion (p = 0.047) was significantly associated with the local distribution. Conclusion: Given that most OSCCs had moderate differentiation of malignancy, identification of clinical features is needed. Attention to the pattern of invasion and location on the tongue can be effective in determining the therapeutic approach.

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Section: Introductionmentioning

confidence: 99%