A review of radiofrequency ablation: Large target tissue necrosis and mathematical modelling

Möser

International Journal of Hyperthermia

et al. 2016

Self Cite

Section: Discussionmentioning

confidence: 99%

A new approach to feedback control of radiofrequency ablation systems for large coagulation zones

Möser

International Journal of Hyperthermia

et al. 2016

Self Cite

“…Heat based treatments subject diseased tissue to hyperthermia, inducing coagulative necrosis, protein denaturation, cytoskeletal breakdown, and severe connective tissue damage [15,[24][25][26][27][28]. Solid tumors in the liver and kidneys have been effectively treated using hyperthermia, yet numerous side effects have been reported [21,24,25,28,29,30].…”

Section: Introductionmentioning

confidence: 99%

Dual thermal ablation of pancreatic cancer cells as an improved combinatorial treatment strategy

Baumann¹,

Baust²,

Snyder³

et al. 2017

Liver Pancreat Sci

Pancreatic cancer (PaCa) is one of the leading causes of cancer related deaths in the world today. It is estimated that 95% of patients diagnosed with PaCa will die because of limited treatment options. As standard treatments have not yielded an improvement in patient outcome, alternative approaches, such as thermal ablation, may offer a new treatment path. We previously reported the lethal temperatures necessary for PaCa ablation for both freeze and heat based treatments. In this study, we investigated the response of PaCa cells in vitro to a combination treatment of heating and freezing, dual thermal ablation (DTA), in an effort to further improve ablation efficacy.PaCa cell lines, PANC-1 and BxPC-3, were subjected to heating (45 to 50°C), freezing (-10 to -20°C), or DTA exposure. Post-exposure viability was assessed over a 7-day recovery interval. Modes of cell death were analyzed using fluorescence microscopy and flow cytometry.Our results indicated that in comparison to single thermal modalities, DTA resulted in greater cell destruction at a more rapid rate. Specifically, -15°C had a moderate impact on day one cell viability (PANC-1=80%; BxPC-3=21%) and 50°C (PANC-1=74%; BxPC-3=18%) caused a slow decline in cell number post-treatment. The combination of these treatments resulted in an increased cell death one-day post-treatment (PANC-1=28%; BxPC-3=5%) and achieved complete cell destruction within three days. Overall, these data suggest that a combination of heat and freeze ablation, DTA, may provide for an improved treatment strategy for PaCa.

Lecture Notes in Computer Science

“…The volumetric heat generated Qp (W/m 3 ) due to the ionic agitation [10] within the biological tissue caused by the high-frequency alternating current during the pulsed RFA procedure [11] is evaluated by…”

Section: Governing Equationsmentioning

confidence: 99%

“…The lethal temperature during the application of RFA for treating target nerve in mitigating chronic pain is considered to be at or above 45-50 o C. Moreover, it is highly undesirable, if the temperature within the biological tissue goes beyond 100 o C during the RFA procedure, as it would result in tissue boiling, vaporization and charring. Indeed, it is known that the charring results in an abrupt rise in the electrical impedance of the tissue surrounding the active tip of the electrode, limiting any further conduction of the thermal energy and acting as a barrier, restricting the energy deposition and reducing the size of ablation volume [9][10].…”

Section: Introductionmentioning

confidence: 99%

Computational Science – ICCS 2019

2019

In this paper, a parametric study has been conducted to evaluate the effects of frequency and duration of the short burst pulses during pulsed radiofrequency ablation (RFA) in treating chronic pain. Affecting the brain and nervous system, this disease remains one of the major challenges in neuroscience and clinical practice. A two-dimensional axisymmetric RFA model has been developed in which a single needle radiofrequency electrode has been inserted. A finite-element-based coupled thermo-electric analysis has been carried out utilizing the simplified Maxwell's equations and the Pennes bioheat transfer equation to compute the electric field and temperature distributions within the computational domain. Comparative studies have been carried out between the continuous and pulsed RFA to highlight the significance of pulsed RFA in chronic pain treatment. The frequencies and durations of short burst RF pulses have been varied from 1 Hz to 10 Hz and from 10 ms to 50 ms, respectively. Such values are most commonly applied in clinical practices for mitigation of chronic pain. By reporting such critical input characteristics as temperature distributions for different frequencies and durations of the RF pulses, this computational study aims at providing the first-hand accurate quantitative information to the clinicians on possible consequences in those cases where these characteristics are varied during the pulsed RFA procedure. The results demonstrate that the efficacy of pulsed RFA is significantly dependent on the duration and frequency of the RF pulses.