A review of protection against exposome factors impacting facial skin barrier function with 89% mineralizing thermal water

Abstract

Background The skin exposome refers to the constellation of external exposures that contribute to cutaneous aging, including solar radiation, air pollution, tobacco smoke, unbalanced nutrition, and cosmetic products. This review explores the skin exposome and the role of a combination hyaluronic acid and mineralized thermal water product used to restore and maintain optimal skin barrier function. Method An expert panel of 7 dermatologists who treat clinical signs of facial aging convened for a one‐day meeting to discuss the results of a literature review on the skin exposome and the role of M89, a mineralized thermal water and hyaluronic acid‐based gel, to improve the quality of facial skin. Evidence coupled with expert opinion and experience of the panel was used to address clinical challenges in the treatment of photo‐aging, and the use of M89. Results Solar radiation (ultraviolet radiation, visible light, and infrared radiation), air pollution, tobacco smoke, nutrition, and miscellaneous factors, including stress, sleep deprivation, and temperature, may potentiate skin aging by triggering molecular processes that damage skin structure. M89 was developed to maintain and restore skin and contains ingredients to aid physical, hydric, antioxidant, and antimicrobial skin barrier function. Conclusions Increasing knowledge of the exposome and microenvironment contributing to skin aging may support a better understanding of measures to support the skin. The initial results of in vitro and clinical studies of M89 show its potential to improve skin barrier function.

Vichy mineralizing water with hyaluronic acid is effective and well tolerated as an adjunct to the management of various dermatoses and after esthetic procedures

“…In agreement with data published by Salsberg et al13 about a clinical study on M89, the product was very well tolerated in both populations with dermatological condition or postprocedures, with no reported safety issues, and was very much appreciated by subjects and investigators.In this survey, the similar results obtained from the two groups (dermatoses and use after esthetic procedures) suggest that M89 facilitates skin barrier restoration.Currently, adjunctive skin care to prescription medications is recognized as being increasingly important in the management of facial dermatoses such as rosacea or sensitive skin, characterized by cutaneous irritation, inflammation, or xerosis, and formulations suitable for sensitive skin are increasingly preferred. M89, a product containing natural active ingredients in a minimalist formulation, is a new advance in the adjunctive skin care.Moreover, esthetic procedures have become increasingly popular to address the signs of skin aging such as facial lines, furrow, wrinkles, and dyschromia; and other signs of damage such as scars.…”

“…13 The chosen, noncomparative study design did not allow comparing the benefit of M89 versus its vehicle or a comparator product. The decrease of prevalence of subjects with clinical signs was statistically significant (P ˂ .0001, see However, especially, lasers, peels, and microdermabrasion can lead to skin barrier damage followed by erythema and irritation.…”

“…Reducing signs and symptoms associated therein will improve patient outcomes and satisfaction. 13 The chosen, noncomparative study design did not allow comparing the benefit of M89 versus its vehicle or a comparator product.…”

In Vitro Effects of Dehydrotrametenolic Acid on Skin Barrier Function

“…HAS-2, stimulated by growth factors, induces HA synthesis in skin keratinocytes [9,10]. Also, HAS-3 plays an essential role in the synthesis of hyaluronan in the epidermis [11]. Another important gene in skin hydration is aquaporin 3 (AQP3), one of 13 isotypes of aquaporin transmembrane channels in humans.…”

Characterization of Reactive and Sensitive Skin Microbiota: Effect of Halymenia durvillei (HD) Extract Treatment

“…The concept of the human skin exposome was introduced more than a decade ago, inducing cutaneous aging, sensitive, and reactive skin [18]. Hyperreactivity of the skin's neural response is postulated to play a role in sensitive skin [19].…”