A review of primary central nervous system neoplasms of cats

Rissi, Daniel R.

doi:10.1177/03009858231155400

Cited by 5 publications

(4 citation statements)

References 105 publications

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“…This slow-growing tumor arises from arachnoid meningeal cells [ 3 ]. Meningioma affects adult cats (3–21 years) [ 1 4 5 6 ], and the median age at diagnosis is 11–12 years [ 2 4 7 ]. In cats, meningiomas are mostly solitary, but multiple meningiomas are not infrequent and may represent up to 17% of cases [ 1 8 9 ].…”

Section: Introductionmentioning

confidence: 99%

Surgical treatment of feline intracranial meningiomas: a retrospective study of 26 cases

Porsmoguer,

Blondel,

Moissonnier

2024

J Vet Sci

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Background Surgical excision is the treatment of choice for feline intracranial meningioma. Objectives To report clinical findings, complications, and outcomes following surgery for feline intracranial meningioma. Methods Medical records (01/2000–01/2017) of cats that underwent surgical excision of an intracranial meningioma at our institution were reviewed. Patient data included signalment, clinical signs, surgical technique, complications, histopathologic diagnosis, survival time, and owners’ answers to a satisfaction questionnaire. Survival was assessed using the Kaplan-Meier method and log-rank test. Results Twenty-six cats were included in this study. The exact cause of death was known in 17 cases and was not related to meningioma in 9/17 cases. Overall median survival time was 881 days (95% confidence interval 518; 1248). The age of the cat did not influence survival ( p = 0.94) or the occurrence of complications ( p = 0.051). Complications occurred in 13/24 cats, including dramatic complications in 4/24 cats. Most complications appeared in the first 24 hours post-surgery (12/13). Males had more postoperative complications ( p = 0.042), including more seizures ( p = 0.016). Cats with cranioplasty had fewer complications ( p = 0.021). Clinical recurrence was confirmed in 3 out of 17 cats. Recurrence-free survival time was 826 days. Most owners (12/14) were satisfied with the outcome. Conclusions Surgical treatment of intracranial meningioma in cats was associated with a long median survival time but also with a high rate of minor and major postoperative complications, including early postoperative seizures. Cranioplasty may reduce complications. Age at the time of surgery had no effect on outcomes.

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Section: Introductionmentioning

confidence: 99%

Surgical treatment of feline intracranial meningiomas: a retrospective study of 26 cases

Porsmoguer,

Blondel,

Moissonnier

2024

J Vet Sci

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“…The frequency of different types of feline spinal cord neoplasms varies according to the affected spinal cord compartment (1)(2)(3)(4)(5). While lymphomas are one of the most commonly diagnosed extradural tumors and is the most frequent type of neoplasia affecting the spinal cord of cats (1,2), intradural/extraparenchymal neoplasms (such as meningiomas and nerve sheath tumors) and intraparenchymal neoplasms (including gliomas) are infrequently reported (4,5). Spinal cord gliomas consist mainly of astrocytomas and oligodendrogliomas (5).…”

Section: Introductionmentioning

confidence: 99%

Case report: Surgical treatment of an astrocytoma in the thoracic spinal cord of a cat

Santifort,

Tamura,

Rissi

et al. 2023

Front. Vet. Sci.

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A 15-year-old spayed female domestic shorthaired cat was evaluated for chronic progressive paraparesis and proprioceptive ataxia. Neurological examination was consistent with a T3–L3 myelopathy. Plain thoracolumbar vertebral column radiographs and CT without intravenous contrast or myelography performed at another facility did not highlight any abnormalities. MRI of the thoracolumbar spinal cord identified an intraparenchymal space-occupying lesion extending from T10–T12. Surgery was performed to remove as much of the mass as possible, and to submit samples for histopathology. A dorsal laminectomy was performed over T9–T13. A midline myelotomy provided access to the mass, which was debrided with an intraoperative estimate of 80% removal. Histopathologic examination was consistent with a diagnosis of an astrocytoma. Post-operative treatment consisted of amoxicillin clavulanic acid, prednisolone, gabapentin, and additional analgesic medications in the direct post-operative period. Over the following 4 months, slow recovery of motor function was seen with continued physiotherapy. During the following 2 months, renal and cardiopulmonary disease were diagnosed and treated by other veterinarians. The cat was also reported to have lost voluntary movement in the pelvic limbs during this period, suggesting regression to paraplegia. Finally, 6 months post-surgery, the owner elected humane euthanasia. This is the second documentation of surgical treatment and outcome of an astrocytoma in the spinal cord of a cat.

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“…24 The biological natures of canine glial tumors have been described in detail, whereas limited information is currently available on feline glial tumors. 18,47 In cats, oligodendroglioma and astrocytoma have immunohistochemical features that correspond to normal oligodendrocytes and astrocytes, namely immunolabeling for OLIG2 and GFAP, respectively. 17,20,48 The expression of doublecortin, a neuronal precursor marker, has also been reported in feline gliomas, suggesting the multipotential differentiation potential of glioma cells.…”

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Immunohistochemical analyses of neural stem cell lineage markers in normal feline brains and glial tumors

et al. 2023

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Neural stem cell (NSC) lineage cells have not been fully identified in feline brains, and the NSC-like nature of feline glial tumors has not been determined. In this study, 6 normal cat brains (3 newborn and 3 older cats) and 13 feline glial tumors were analyzed using immunohistochemical NSC lineage markers. The feline glial tumors were subjected to immunohistochemical scoring followed by hierarchical cluster analysis. In newborn brains, glial acidic fibrillary protein (GFAP)/nestin/sex-determining region Y-box transcription factor 2 (SOX2)-immunopositive NSCs, SOX2-immunopositive intermediate progenitor cells, oligodendrocyte transcription factor 2 (OLIG2)/platelet-derived growth factor receptor-α (PDGFR-α)-immunopositive oligodendrocyte precursor cells (OPCs), OLIG2/GFAP-immunopositive immature astrocytes, and neuronal nuclear (NeuN)/β-3 tubulin-immunopositive mature neuronal cells were observed. The apical membrane of NSCs was also immunopositive for Na+/H+ exchanger regulatory factor 1 (NHERF1). In mature brains, the NSC lineage cells were similar to those of the newborn brains. A total of 13 glial tumors consisted of 2 oligodendrogliomas, 4 astrocytomas, 3 subependymomas, and 4 ependymomas. Astrocytomas, subependymomas, and ependymomas were immunopositive for GFAP, nestin, and SOX2. Subependymomas and ependymomas showed dot-like or apical membrane immunolabeling for NHERF1, respectively. Astrocytomas were immunopositive for OLIG2. Oligodendrogliomas and subependymomas were immunopositive for OLIG2 and PDGFR-α. Feline glial tumors also showed variable immunolabeling for β-3 tubulin, NeuN, and synaptophysin. Based on these results, feline astrocytomas, subependymomas, and ependymomas appear to have an NSC-like immunophenotype. In addition, astrocytomas, subependymomas, and ependymomas have the characteristics of glial, oligodendrocyte precursor, and ependymal cells, respectively. Feline oligodendrogliomas likely have an OPC-like immunophenotype. In addition, feline glial tumors may have multipotential stemness for differentiation into neuronal cells. These preliminary results should be validated by gene expression analyses in future studies with larger case numbers.

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A review of primary central nervous system neoplasms of cats

Cited by 5 publications

References 105 publications

Surgical treatment of feline intracranial meningiomas: a retrospective study of 26 cases

Surgical treatment of feline intracranial meningiomas: a retrospective study of 26 cases

Case report: Surgical treatment of an astrocytoma in the thoracic spinal cord of a cat

Immunohistochemical analyses of neural stem cell lineage markers in normal feline brains and glial tumors

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