A review of prevention of surgical site infections in Indian hospitals based on global guidelines for the prevention of surgical site infection, 2016

Arora, Anita; Bharadwaj, Puneet; Chaturvedi, Harit; Chowbey, P. K.; Gupta, Saurabh Kumar; Leaper, David; Mani, GK; Marya, SK S; Premnath, R; Quadros, K. R.; Srivastava, Achal; Ag, Tendolkar

doi:10.4103/jpsic.jpsic_29_17

Cited by 15 publications

(2 citation statements)

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“…With multidrug-resistant (MDR) and extensively drug-resistant (XDR) bacterial infections, the mortality risk increases multifold depending on the degree of resistance, the organism, and associated risk factors [3]. Acute and chronic wound infections are significant problems, and 20% of surgical sites and 40% of diabetic wounds infected with resistant bacteria have been reported from India [4,5]. The common organisms isolated from the wound infections are Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Acinetobacter baumannii, and Klebsiella pneumonia [5].…”

Section: Introductionmentioning

confidence: 99%

Effect of Topical Silver Nanoparticle Formulation on Wound Bacteria Clearance and Healing in Patients With Infected Wounds Compared to Standard Topical Antibiotic Application: A Randomized Open-Label Parallel Clinical Trial

Pathi,

Mishra,

Moharana

et al. 2024

Cureus

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Background: Infected wounds pose a special challenge for management, with an increased risk of wound chronicity, systemic infection, and the emergence of antibiotic resistance. Silver nanoparticles have multimodal effects on bacteria clearance and wound healing. This study aimed to document the efficacy of a topical silver nanoparticle-based cream on bacteria clearance and wound healing in infected wounds compared to Mupirocin.Methods: This open-label parallel randomized clinical trial allocated 86 participants with infected wounds (culture-positive) into Kadermin, silver nanoparticle-based cream arm (n=43) and Mupirocin arm (n=43) and documented the swab culture on day 5 and wound healing at day 28, along with periodic wound status using the Bates-Jensen Wound Assessment Tool. Patients received oral/systemic antibiotics and other medications for underlying diseases. The intention-to-treat principle was adopted for data analysis using the chi-square and Student t tests to document the differences between groups according to variable characteristics.Results: All participants completed the follow-up. On day 5, wound bacteria clearance was observed in 86% and 65.1% of the participants in the Kadermin and Mupirocin arms, respectively (p=0.023). At day 28, complete wound healing was observed in 81.4% and 37.2% of the participants in the Kadermin and Mupirocin arms, respectively (p≤0.001). No local or systemic adverse event or local reaction was observed in any of the participants. Conclusion: Kadermin, the silver nanoparticle-based cream, has better efficacy in achieving faster wound bacteria clearance and healing in infected wounds compared to Mupirocin. This may have relevance for its use as an antibiotic-sparing agent in wound management.

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Section: Introductionmentioning

confidence: 99%

Effect of Topical Silver Nanoparticle Formulation on Wound Bacteria Clearance and Healing in Patients With Infected Wounds Compared to Standard Topical Antibiotic Application: A Randomized Open-Label Parallel Clinical Trial

Pathi,

Mishra,

Moharana

et al. 2024

Cureus

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“…A study conducted by A Arora et al states that while the global incidence of SSI is around 0.5% to 15%, SSI in India is considerably higher ranging from 23% to 38% [1] Surgical Site Infection incidents may be influenced by surgical environment, room temperature and humidity, type of surgery, pre-and post-operative care. SSI prevention may be carried out by different surgeons by way of Occlusive dressing or Open Wound treatment.…”

Section: Introductionmentioning

confidence: 99%

Comparative Analysis of Occlusive Dressing and Open Wound Treatment in Prevention of Surgical Site Infections

Srivastava

Solanki

2019

Int. J. Res. Granthaalayah

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Surgical site infections (SSIs) are defined as infections of the tissues, organs, or spaces exposed by surgeons during performance of an invasive procedure. Motivation/Background: A lot of expense both with regards to nursing time and dressing material costs is invested in prevention of SSI using occlusive surgical incision site dressing. But to what extent is this beneficial over open wound treatment? In the present study, we have compared the incidence of SSIs in surgical wounds treated with occlusive dressings versus those treated with open wound treatment to find out the same. Method: The study was conducted on 860 patients of General Surgery wards. Patients were categorized under two groups of cases where (1) Dressing was opened after 24 hours and then only open wound treatment by cleaning with Betadine 12 hourly was done till stitch removal and (2) Dressing was opened after 48 hours and then again after every 2 days occlusive dressing was done until stitch removal. Result: A Chi-Square Test was performed to understand if Occlusive dressings have an added advantage over Open Wound Treatment in prevention of SSIs. Conclusion: Occlusive Dressings have no added advantage over Open Wound Treatment in the prevention of SSIs and hence Open wound treatment can be taken as an alternative for occlusive dressings.

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Feasibility of tele-visits after elective ventral hernia surgery: Experience from an Indian tertiary care center

Bansal,

Kamath,

Waghmare

et al. 2024

Surgery

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A review of prevention of surgical site infections in Indian hospitals based on global guidelines for the prevention of surgical site infection, 2016

Cited by 15 publications

References 1 publication

Effect of Topical Silver Nanoparticle Formulation on Wound Bacteria Clearance and Healing in Patients With Infected Wounds Compared to Standard Topical Antibiotic Application: A Randomized Open-Label Parallel Clinical Trial

Effect of Topical Silver Nanoparticle Formulation on Wound Bacteria Clearance and Healing in Patients With Infected Wounds Compared to Standard Topical Antibiotic Application: A Randomized Open-Label Parallel Clinical Trial

Comparative Analysis of Occlusive Dressing and Open Wound Treatment in Prevention of Surgical Site Infections

Feasibility of tele-visits after elective ventral hernia surgery: Experience from an Indian tertiary care center

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