A Review of Polyherbal Formulation “Sagadevi Nei” (Vernonia cinerea ghee) in the Management of Chronic Kidney Disorders

Abstract

Chronic Kidney disease is an emerging non-communicable disease with progressive degeneration of renal tubules leading to abnormal excretion of albumin in urine and increased levels of serum creatinine and blood urea. It is more prevalent in patients with diabetes mellitus and hypertension. Sagadevi Nei is a Siddha polyherbal formulation with 11 ingredients, mainly consisting of leaf juice of Vernonia cinerea, it is indicated for the treatment of oliguria and anuria (Neersurukku, Neerkattu) i.e., reduced urinary output and absence of urination. Sagadevi Nei has been proven for its antimicrobial activity [3] against UTI-causing microbes and E. coli biofilm prevention. This review aims to assess the polyherbal formulation "Sagadevi Nei" (SN) for the management of chronic kidney disease (CKD). The constituents of this formulation have also been proven for their antioxidant, anti-inflammatory, diuretic, and nephroprotective activities. Especially the main ingredient, Vernonia cinerea, has been demonstrated for its A Review of … B. Abarna et al.