Polymer fibers have been employed in many biomedical applications -for example, sutures, tissue engineering matrices, gauzes and bandages, and drug delivery devices. These are made of either non-biodegradable polymers or biodegradable polymers, such as poly (lactide-co-glycolide). Nanofiber-based materials have several advantages compared to conventional fibers. In particular, they represent a very large surface area to volume ratio, high porosity, and variable pore-size distribution. Additionally, the surface functionality is possible to influence, and various morphologies are achievable, including nanotubes. Recently, electrospun nanofiber matrices have garnered a lot of attention and shown great potential in biomedical applications. The three-dimensional synthetic biodegradable scaffolds are designed utilizing nanofibers to serve as an excellent framework for cell adhesion, proliferation, and differentiation. Physiochemical properties of nanofiber scaffolds can be governed by manipulating electrospinning parameters to meet the demands of a specific applications. Various attempts have been made to modify nanofiber surfaces with several bioactive molecules to allow cells with the requisite chemical cues and a more in vivo -like environment. Nanofibers have been used as scaffolds for skin tissue engineering, musculoskeletal tissue engineering (bone, cartilage, ligament, and skeletal muscle), vascular tissue engineering, neural tissue engineering, and as carriers for the controlled