A Review of Plant-based Diets to Prevent and Treat Heart Failure

Kerley, Conor P

doi:10.15420/cfr.2018:1:1

Cited by 43 publications

(45 citation statements)

References 113 publications

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“…90,91 In addition, a high-fiber diet has been reported to prevent the development of HF and effectively improve cardiac remodeling. 92 Kerley et al 93 found that for HF patients, a plant-based diet rich in fruits, vegetables, beans and whole wheat might be beneficial; the role of nuts, dairy products, and poultry is controversial; yet red or processed meat, eggs, and refined carbohydrates seem to be harmful.…”

Section: Gutàtmaoàhf Axis As a Potential Therapeutic Target For Hfmentioning

confidence: 99%

TMAO: how gut microbiota contributes to heart failure

Zhang

Wang

et al. 2021

Translational Research

150

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An increasing amount of evidence reveals that the gut microbiota is involved in the pathogenesis and progression of various cardiovascular diseases. In patients with heart failure (HF), splanchnic hypoperfusion causes ischemia and intestinal edema, allowing bacterial translocation and bacterial metabolites to enter the blood circulation via an impaired intestinal barrier. This results in local and systemic inflammatory responses. Gut microbe-derived metabolites are implicated in the pathology of multiple diseases, including HF. These landmark findings suggest that gut microbiota influences the host's metabolic health, either directly or indirectly by producing several metabolites. In this review, we mainly discuss a newly identified gut microbiota-dependent metabolite, trimethylamine N-oxide (TMAO), which appears to participate in the pathologic processes of HF and can serve as an early warning marker to identify individuals who are at the risk of disease progression. We also discuss the potential of the gutÀTMAOÀHF axis as a new target for HF treatment and highlight the current controversies and potentially new and exciting directions for future research.

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Section: Gutàtmaoàhf Axis As a Potential Therapeutic Target For Hfmentioning

confidence: 99%

TMAO: how gut microbiota contributes to heart failure

Zhang

Wang

et al. 2021

Translational Research

150

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“…Furthermore, it seems important to investigate if specific types of fruit and vegetables are more protective than others by investigating mechanisms of action. To do that a food diary and ideally blood samples would be required in order to analyse nutritional biomarkers of intake (44) . Future research should also aim at developing and evaluating interventions which will increase the intake of fruit and vegetables in the population, and especially among men.…”

Section: Future Researchmentioning

confidence: 99%

Consumption of fruit and vegetables and the risk of type 2 diabetes: a 4-year longitudinal study among Swedish adults

et al. 2020

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A low intake of fruit and vegetables is a significant contributor to the global burden of disease. The aim of this study was to estimate the size of the risk of type 2 diabetes (T2D) of a low intake and to investigate possible sex differences. In this regard, this study used a longitudinal data from the Stockholm Public Health Cohort located in Sweden, collected in 2010 and 2014. The analysis included 14 718 men and 20 589 women aged 25 to 84 years. Fruit and vegetable intake, separately <2 servings/d or combined <4 servings/d (one serving corresponding to 100 g) was set as a cut-point for low intake. The sex difference at baseline was examined. Sex-stratified logistic regression was performed with onset of T2D as the outcome and fruit and vegetable intake at baseline as the exposure with adjustment for other known risk factors. Results indicate that men consumed significantly (P < 0⋅001) less fruit and vegetables compared with women. A 62 % higher risk to develop T2D over the 4-year period was observed in men who had low vegetable intake compared with high intake after adjusting for age, education, BMI, smoking, alcohol and physical activity (OR 1⋅62; 95 % CI 1⋅00, 2⋅63). In women, a significantly higher risk of T2D was also observed with a low intake of vegetables, but not after adjustment. The present study suggests that higher consumption of vegetables seems to be protective for the onset of T2D in men. Thus, increasing the intake of vegetables in men should be a public health priority.

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“…Other important risk factors for AF include heart failure and coronary artery disease (CAD) . Plant‐based diets may beneficially affect both entities and have been shown to be able to halt and even reverse CAD . The Lifestyle Heart Trial published by Ornish and colleagues found that more than 80% of patients diagnosed with heart disease who followed a plant‐based diet (lifestyle‐)program had some level of regression of atherosclerosis and 91% had a reduction in the frequency of angina episodes .…”

Section: Risk Factor Modification Through Dietary Modificationmentioning

confidence: 99%

“…Heart failure is associated with high rates of morbidity and mortality and, above that, one of the most important risk factors for incident AF . There is interventional and observational evidence that a plant‐based diet may decrease the incidence and severity of heart failure . More recently, several case reports on plant‐based diets as a potential therapeutic approach in the treatment of heart failure have been published .…”

Section: Risk Factor Modification Through Dietary Modificationmentioning

confidence: 99%

“…More recently, several case reports on plant‐based diets as a potential therapeutic approach in the treatment of heart failure have been published . While well‐designed and large randomized, controlled nutrition intervention trials are missing with regard to this entity, a series of potential mechanisms on how a plant‐based diet may beneficially affect heart failure have been postulated . These include decreased oxidative stress and inflammation levels, increased nitric oxide bioavailability, reduced homocysteine levels, and increased levels of antioxidants …”

Section: Risk Factor Modification Through Dietary Modificationmentioning

confidence: 99%

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Atrial fibrillation risk factor management with a plant‐based diet: A review

Storz¹,

Helle²

2019

Journal of Arrhythmia

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Atrial fibrillation is the most prevalent cardiac arrhythmia in the clinical setting affecting approximately 34 million individuals worldwide. The disease is associated with a significant burden of morbidity and mortality resulting from stroke, heart failure, and acute coronary syndrome. Atrial fibrillation is now a major public health problem with tremendous implications on the economy and the world's healthcare systems. Numerous risk factors and clinical conditions that are associated with the development and progression of atrial fibrillation have been identified in the past. Within the last decades, a shift in awareness toward modifiable conditions has been observed and risk factor management has gained significant momentum. In light of this, dietary approaches are of paramount importance. Whole‐food plant‐based diets emphasizing grains, legumes, vegetables, fruits and nuts and excluding most (or all) animal products have recently experienced a significantly increased interest. The purpose of this review is to present evidence suggestive of a plant‐based diet being a valuable tool in atrial fibrillation risk factor management. The effects of a plant‐based diet on both established and emerging risk factors, such as inflammation and subclinical atherosclerosis, are reviewed in this article. A special focus is put on cardiovascular and metabolic risk factors including hypertension, coronary artery disease, diabetes, and obesity.

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A Review of Plant-based Diets to Prevent and Treat Heart Failure

Cited by 43 publications

References 113 publications

TMAO: how gut microbiota contributes to heart failure

TMAO: how gut microbiota contributes to heart failure

Consumption of fruit and vegetables and the risk of type 2 diabetes: a 4-year longitudinal study among Swedish adults

Atrial fibrillation risk factor management with a plant‐based diet: A review

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