A review of pharmacological and pharmacokinetic properties of Forsythiaside A

Gong, Lihong; Wang, Cheng; Zhou, Honglin; Ma, Cheng; Zhang, Yafang; Peng, Cheng; Li, Yunxia

doi:10.1016/j.phrs.2021.105690

Cited by 56 publications

(37 citation statements)

References 154 publications

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“…Nuclear factor-κB (NF-κB) is a family of transcription factors, and has long been considered the central mediator of the process in inflammation and immunity (Kim et al, 2017;Zhang et al, 2017). TLR4 is one of the most critical upstream signaling axis molecules for NF-κB pathway activation, which in turn manage the secretion of varieties of proinflammatory cytokines, chemokines, and adhesion molecules (Yoshimura, 2006;Gong et al, 2021).…”

Section: Inhibition Of Nf-κbmentioning

confidence: 99%

Alpinetin: A Review of Its Pharmacology and Pharmacokinetics

et al. 2022

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Flavonoids isolated from medicinal herbs have been utilized as valuable health-care agents due to their virous biological applications. Alpinetin is a natural flavonoid that emerges in many widely used medicinal plants, and has been frequently applied in Chinese patent drugs. Accumulated evidence has demonstrated that alpinetin possesses a broad range of pharmacological activities such as antitumor, antiinflammation, hepatoprotective, cardiovascular protective, lung protective, antibacterial, antiviral, neuroprotective, and other properties through regulating multiple signaling pathways with low systemic toxicity. However, pharmacokinetic studies have documented that alpinetin may have poor oral bioavailability correlated to its extensive glucuronidation. Currently, the reported pharmacological properties and pharmacokinetics profiles of alpinetin are rare to be scientifically reviewed. In this article, we aimed to highlight the mechanisms of action of alpinetin in various diseases to strongly support its curative potentials for prospective clinical applications. We also summarized the pharmacokinetics properties and proposed some viable strategies to convey an appreciable reference for future advances of alpinetin in drug development.

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Section: Inhibition Of Nf-κbmentioning

confidence: 99%

Alpinetin: A Review of Its Pharmacology and Pharmacokinetics

et al. 2022

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“…Yi et al reported that the aqueous extract of Forsythia suspensa fruits (EFSF) and its major ingredient, FSA, demonstrated an effective neuroprotective function against oxaliplatin-induced neurotoxicity in vitro and in vivo and did not interfere with anti-tumor activity ( Yi et al, 2019b ). Previous studies have shown that Forsythia suspensa and FSA exhibit significant anti-inflammatory and antioxidant pharmacological and biological activities ( Cheng et al, 2014 ; Gong et al, 2021 ). Therefore, the regulatory mechanisms may be associated with oxaliplatin-induced neuroinflammation, oxidative stress, mitochondrial dysfunction, or axonal degeneration.…”

Section: Plant-derived Medicines Limiting Platinum-induced Peripheral Neurotoxicitymentioning

confidence: 99%

Application Potential of Plant-Derived Medicines in Prevention and Treatment of Platinum-Induced Peripheral Neurotoxicity

Jia

et al. 2022

Front. Pharmacol.

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As observed with other chemotherapeutic agents, the clinical application of platinum agents is a double-edged sword. Platinum-induced peripheral neuropathy (PIPN) is a common adverse event that negatively affects clinical outcomes and patients’ quality of life. Considering the unavailability of effective established agents for preventing or treating PIPN and the increasing population of cancer survivors, the identification and development of novel, effective interventions are the need of the hour. Plant-derived medicines, recognized as ideal agents, can not only help improve PIPN without affecting chemotherapy efficacy, but may also produce synergy. In this review, we present a brief summary of the mechanisms of platinum agents and PIPN and then focus on exploring the preventive or curative effects and underlying mechanisms of plant-derived medicines, which have been evaluated under platinum-induced neurotoxicity conditions. We identified 11 plant extracts as well as 17 plant secondary metabolites, and four polyherbal preparations. Their effects against PIPN are focused on oxidative stress and mitochondrial dysfunction, glial activation and inflammation response, and ion channel dysfunction. Also, ten clinical trials have assessed the effect of herbal products in patients with PIPN. The understanding of the molecular mechanism is still limited, the quality of clinical trials need to be further improved, and in terms of their efficacy, safety, and cost effectiveness studies have not provided sufficient evidence to establish a standard practice. But plant-derived medicines have been found to be invaluable sources for the development of natural agents with beneficial effects in the prevention and treatment of PIPN.

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“…Chinese herbal medicine, which is a tremendous treasure trove of human medical development, has indeed demonstrated tangible advantages in the treatment of liver illness. Using contemporary technologies to excavate this treasure trove of potent medicinal components, more and more small-molecule compounds have been discovered from Chinese herbs, such as Flos inulae ( Yang et al, 2021 ), Forsythiaside A ( Gong et al, 2021 ), and Baicalin ( Hu et al, 2021 ). Astragalus membranaceus (AM), also known in China as Huangqi , has been used to replenish qi and blood for over two millennia and is suitable for deficiency disorders ( Auyeung et al, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

Pharmacological Effects and Molecular Protective Mechanisms of Astragalus Polysaccharides on Nonalcoholic Fatty Liver Disease

Zhang

Qian

2022

Front. Pharmacol.

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Nonalcoholic fatty liver disease (NAFLD) has been renamed metabolic dysfunction-associated fatty liver disease (MAFLD), a condition for which there is now no authorized treatment. The search for new medications to treat MAFLD made from natural substances is gaining traction. The function of anti-oxidant, anti-inflammation, hypoglycaemic, antiviral, hypolipidemic, and immunomodulatory actions of Astragalus polysaccharides (APS), a chemical molecule isolated from Astragalus membranaceus, has become the focus of therapeutic attention. We have a large number of papers on the pharmacological effects of APS on NAFLD that have never been systematically reviewed before. According to our findings, APS may help to slow the progression of non-alcoholic fatty liver disease (NAFL) to non-alcoholic steatohepatitis (NASH). Lipid metabolism, insulin resistance (IR), oxidative stress (OS), endoplasmic reticulum stress (ERS), inflammation, fibrosis, autophagy, and apoptosis are some of the pathogenic pathways involved. SIRT1/PPARα/FGF21, PI3K/AKT/IRS-1, AMPK/ACC, mTOR/4EBP-1/S6K1, GRP78/IRE-1/JNK, AMPK/PGC-1/NRF1, TLR4/MyD88/NF-κB, and TGF-β/Smad pathways were the most common molecular protective mechanisms. All of the information presented in this review suggests that APS is a natural medication with a lot of promise for NAFLD, but more study, bioavailability studies, medicine type and dosage, and clinical proof are needed. This review could be useful for basic research, pharmacological development, and therapeutic applications of APS in the management of MAFLD.

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A review of pharmacological and pharmacokinetic properties of Forsythiaside A

Cited by 56 publications

References 154 publications

Alpinetin: A Review of Its Pharmacology and Pharmacokinetics

Alpinetin: A Review of Its Pharmacology and Pharmacokinetics

Application Potential of Plant-Derived Medicines in Prevention and Treatment of Platinum-Induced Peripheral Neurotoxicity

Pharmacological Effects and Molecular Protective Mechanisms of Astragalus Polysaccharides on Nonalcoholic Fatty Liver Disease

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