This article examined the predisposing factors that challenge the practice of adoption amongst childless Christians in Africa. Childlessness in African cultural context is seen as a misnomer. In the extreme, it is considered a tragedy that comes with stigmatization, psychological and emotional pains, grief, anxiety and depression to married couples, families and especially, the women. However, opportunities abound for Christian couples who are experiencing involuntary childlessness to enthusiastically welcome and embrace adoption, but this is not generally so, in spite of the ease, permanency and cost involved. The reason being that myriads of challenges bedeviling child adoption have given rise to its non-acceptance even among Christians in many quarters. Using phenomenological method and secondary sources of data collection, the research discovered that many coping strategies like surrogacy, Assisted Reproductive Technology (ART), guardianship, fostering and adoption are available to childless Christian couples. It recommended that Church leaders should educate their couples to see adoption as a viable option with biblical support, which should be embraced to close the yearning gap of childlessness. That government should remove all the bottlenecks hindering and discouraging childless couples from adoption. This done, the much eluded joy of parenthood which is the major essence and key to marriages will significantly be restored.