A Review of Pediatric Corneal Transplants: Perioperative, Operative, and Postoperative Management

Park, Benjamin; Ziari, Melody; Castro, Hannah Muniz; Ali, Shazia F

doi:10.1097/iio.0000000000000398

Cited by 1 publication

(2 citation statements)

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“…This includes corneal transplantation and corneal stromal stem cellular therapy. [ 9 10 ] Corneal transplantation involves the transplant of a donor cornea which would have the normal curvature and biochemical structure. However, keeping in view, the corneal regeneration process initiating from the peripheral limbus to the center and the abnormal recipient curvature in CP, the long-term success of the transplant is questionable.…”

Section: Discussionmentioning

confidence: 99%

“…However, keeping in view, the corneal regeneration process initiating from the peripheral limbus to the center and the abnormal recipient curvature in CP, the long-term success of the transplant is questionable. [ 10 ] Cellular therapy with ocular and extraocular stem cells may correct the underlying deficiency of functional keratocan preventing the progression of the condition. [ 9 ]…”

Section: Discussionmentioning

confidence: 99%

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Cornea plana in a family from Pakistan: Case series and literature review on the principles of management

Zameer,

Khan,

Janjua

et al. 2023

Oman J Ophthalmol

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Cornea plana (CP) is a rare ocular condition existing in two distinct clinical and hereditary forms: a milder, autosomal dominant type I and a more severe, autosomal recessive type II. The condition is more commonly found in Finnish, Saudi, and Czech families. We report three brothers from a consanguineous marriage that presented with complaints of decreased vision of varying degrees. All three of them have blue, thick, and hazy corneas with shallow anterior chamber depths. The additional features of CP type II were seen in the older two brothers including arcus lipoids, ill-demarcated limbus, and an accommodative squint. They were managed by the correction of refractive errors through spectacles and detailed counseling with follow-up visits to look for progressive complications. The management is mainly centered around optically or surgically correcting the developmental anomalies. This is complimented with proper genetic counseling and regular follow-up visits to look for and manage complications. There are, however, novel therapies that can be considered in these patients including corneal transplants or corneal stromal stem cellular therapies.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%