“…A core outcome & measurement set is desperately needed in this field and hopefully the Defining Standards in Colorectal Optimisation (DiSCO) Study will report soon [3]. Secondly, the design and conduct of the available RCTs has been called into question [4]. The trials have sample sizes that vary by over an order of magnitude and relatively low rates of recruitment compared to the number screened, which raises concerns regarding external validity and applicability.…”