2020
DOI: 10.3390/app10248858
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A Review of Passive Constant Flow Regulators for Microfluidic Applications

Abstract: This review gives an overview of passive constant flow regulators dedicated to microfluidic applications. Without external control and energy consumption, these devices deliver a constant flow rate regardless of pressure variations, making them very attractive for various microfluidic applications, including drug delivery, flow chemistry, point-of-care tests, or microdialysis. This technical review examines progress over the last three decades in the development of these flow regulators and focuses on the work… Show more

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Cited by 17 publications
(20 citation statements)
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References 61 publications
(123 reference statements)
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“…Therefore, the MPV is compact, reliable, maintenance-free, which requires no energy. The flow regulators of MPV are dominated by the mechanical regulators having moving components (membrane, piston, cantilever, leaflet, and so on) [ 26 ]. For the MPV with a membrane as the mechanical regulator, the internal fluid pressure drives the elastic membrane to deform, thereby controlling the flow or the switch of opening and closing.…”
Section: Introductionmentioning
confidence: 99%
“…Therefore, the MPV is compact, reliable, maintenance-free, which requires no energy. The flow regulators of MPV are dominated by the mechanical regulators having moving components (membrane, piston, cantilever, leaflet, and so on) [ 26 ]. For the MPV with a membrane as the mechanical regulator, the internal fluid pressure drives the elastic membrane to deform, thereby controlling the flow or the switch of opening and closing.…”
Section: Introductionmentioning
confidence: 99%
“…Use of bare elastomers to passively regulate flow in microfluidic channels has been previously reported in literature for many decades ( Chappel, 2020 ). This is generally accomplished by designing a channel with elastomeric walls which contract as pressure increases, regulating the flow rate (or restricting it entirely if pressure is sufficiently high) although more complicated designs have been reported ( Mosadegh et al., 2010 ).…”
Section: Introductionmentioning
confidence: 99%
“…Constant flow valves, also known as passive flow control valves, auto regulated valves, or pressurecompensated valves, output a constant flow rate regardless of pressure changes. As it does not require additional energy to drive and has a simple and compact structure, constant flow valve is widely used in industrial water treatment, centrifugal pump protection, irrigation, and other fields [5].…”
Section: Introductionmentioning
confidence: 99%