A Review of Oral Fungal Infections and Appropriate Therapy

Muzyka, Brian C.; Glick, Michael

doi:10.14219/jada.archive.1995.0025

Cited by 39 publications

(49 citation statements)

References 45 publications

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“…Discovered in the 1950s, by the New York State Health Laboratory, it was the fi rst effective treatment for the cure of oral candidosis (Giannini and Shetty 2011 ;Melkoumov et al 2013 ;Muzyka and Glick 1995 ;Vazquez 2010 ;Pappas et al 2009 ;Park and Kang 2011 ;Klotz 2006 ;Neville et al 2002 ;Greenspan 1994 ). Derived from Streptomyces noursei culture, this macrolide resembles in its structure the amphotericin B.…”

Section: Nystatinmentioning

confidence: 99%

“…It was the fi rst drug used for the treatment of systemic candidosis orally (Giannini and Shetty 2011 ;Muzyka and Glick 1995 ;Vazquez 2010 ;Pappas et al 2009 ;Park and Kang 2011 ;Klotz 2006 ;Sharon and Fazel 2010 ;Thompson et al 2010 ;Neville et al 2002 ;Greenspan 1994 ;Van Roey et al 2004 ). Only in rare cases of resistance to other antifungals the prescription of ketoconazole is necessary.…”

Section: Ketoconazolementioning

confidence: 99%

“…It is one of the newest synthetic triazole agents, being less toxic than other antifungal (Giannini and Shetty 2011 ;Muzyka and Glick 1995 ;Vazquez 2010 ;Pappas et al 2009 ;Park and Kang 2011 ;Sharon and Fazel 2010 ;Thompson et al 2010 ;Neville et al 2002 ;Greenspan 1994 ).…”

Section: Itraconazolementioning

confidence: 99%

“…Very effective medication due to the greater specifi city than ketoconazole in the treatment of oral candidosis, especially in immunocompromised and immunosuppressed individuals (Giannini and Shetty 2011 ;Muzyka and Glick 1995 ;Vazquez 2010 ;Pappas et al 2009 ;Park and Kang 2011 ;Klotz 2006 ;Sharon and Fazel 2010 ;Thompson et al 2010 ;Neville et al 2002 ;Sangeorzan et al 1994 ;Bozzette 2005 ;Hamza et al 2008 ;Millon et al 1994 ;Nairy et al 2011 ;Neoh et al 2011 ;Reboli et al 2007 ;Rex et al 1995 ;Vazquez et al 2006 ). In HIV seropositive patients, it is also used as prophylaxis against candidosis weekly.…”

Section: Fluconazolementioning

confidence: 99%

“…However, these drugs have more side effects, and their selection should consider important interactions with other medicines (Muzyka and Glick 1995 ).…”

mentioning

confidence: 99%

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Antifungals for Candidosis Treatment

et al. 2015

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The available treatments for oral candidosis have proved to be more effi cacious with the use of new and known antifungal drugs. The success of these is directly related to the correct diagnosis, identifi cation, and correction of etiological factors and the commitment of the patient. In the absence of some of these factors, the antifungal therapy results only in a brief relief from disease, triggering relapses. This chapter presents the main drugs used in the treatment of oral and oropharyngeal candidosis, their functioning in the human body, and their mechanism of action in the destruction of the pathogenic agent.

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Section: Nystatinmentioning

confidence: 99%

Section: Ketoconazolementioning

confidence: 99%

Section: Itraconazolementioning

confidence: 99%

Section: Fluconazolementioning

confidence: 99%

“…However, these drugs have more side effects, and their selection should consider important interactions with other medicines (Muzyka and Glick 1995 ).…”

mentioning

confidence: 99%

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Antifungals for Candidosis Treatment

et al. 2015

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Fungi in Endodontic Infections

Şen¹,

Baksı²

2017

Endodontic Microbiology

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Antifungal activity of DNA–lipid complexes and DNA–lipid films against Candida species

Inoue

Fukushima

Hayakawa

et al. 2005

J Biomedical Materials Res

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In this study amphiphilic lipids, DNA-lipid complexes, and DNA-lipid films were prepared, and their antifungal activity against Candida species was examined. The amphiphilic lipids were synthesized from a reaction of glycine or L-alanine with n-alkyl alcohol in the presence of p-toluene sulfonic acid. DNA-lipid complexes, which were prepared by the simple mixing of DNA and amphiphilic lipids, were insoluble in water. Self-standing, water-insoluble DNA-lipid films were prepared by casting the DNA-lipid complexes from a chloroform/ethanol solution. The antifungal activities of the lipids and DNA-lipid complexes against the Candida species were evaluated by minimum inhibitory concentrations (MICs); those of DNA-lipid films were evaluated by the disk diffusion method. The seven kinds of lipids, DNA-lipid complexes, and DNA-lipid films showed antifungal activity, and no differences were seen in the antifungal activities between glycine and L-alanine derivatives. The lipids, DNA-lipid complexes, and DNA-lipid films, which have shorter alkyl chain length in lipids, showed antifungal activity against all Candida species. However, the effect of antifungal activity against Candida species decreased with increased alkyl chain length in lipids. In this study, it was found that lipids, DNA-lipid complexes, and films with a decyl or dodecyl group exhibit more favorable antifungal activity.

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A Review of Oral Fungal Infections and Appropriate Therapy

Cited by 39 publications

References 45 publications

Antifungals for Candidosis Treatment

Antifungals for Candidosis Treatment

Fungi in Endodontic Infections

Antifungal activity of DNA–lipid complexes and DNA–lipid films against Candida species

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