A review of novel STING bulking agents

Starmer, Benjamin; McAndrew, Fiona; Corbett, Harriet J.

doi:10.1016/j.jpurol.2019.08.018

Cited by 13 publications

(5 citation statements)

References 23 publications

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“…Hyaluronic acid-based fillers are particularly attractive filler as they are found in the extracellular matrix of all mammalian species and theoretically have lower immunogenic risk [14]. Deflux is a relatively newer dextranomer/hyaluronic acid copolymer that is used primarily as a long-term bulking agent in pediatric urology for treatment of vesicoureteral reflux [10,15]. Deflux had previously shown initial promise in animal studies for treating vocal fold insufficiency and is particularly appealing given its longer duration of action compared to other available fillers [16,17].…”

Section: Discussionmentioning

confidence: 99%

A Rare Case of Actinomyces odontolyticus Infection after Injection Laryngoplasty with Deflux

Munroe¹,

Jonathan²,

Brown³

2020

J Otolaryngol Rhinol

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Section: Discussionmentioning

confidence: 99%

A Rare Case of Actinomyces odontolyticus Infection after Injection Laryngoplasty with Deflux

Munroe¹,

Jonathan²,

Brown³

2020

J Otolaryngol Rhinol

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“…In a study on predictive factors of ureteral obstruction after endoscopic treatment of VUR, univariate analysis revealedthat Grade V VUR was one of the significant independent risk factors leading to obstruction 22. Regarding the laterality of reflux, several authors report a predominance of bilateral VUR in patients undergoing endoscopic treatment; the results of the present investigation correspond with those of these authors 13, 14, 16, 18, 19. Others report a predominance of unilateral VUR 17,23. The first endoscopic injection technique described by O'Donnel and Puri was STING (subureteric teflon injection) and a modification of it called HIT (hydrodistention implantation technique) was later introduced. These techniques have been combined and modified giving rise to four techniques; STING, HIT, double HIT and combined STING/HIT 8.…”

Section: Source: Clinical Historymentioning

confidence: 99%

Complications of Endoscopic Treatment With Vantris in Primary Vesicoureteral Reflux in Childhood

Martínez,

Gomez,

Jackson

et al. 2024

JHS

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Introduction: VUR constitutes 20% of the causes of chronic kidney disease in childhood Objective: to determine the complications of endoscopic treatment of primary VUR with the use of Vantris. Material and methods: A descriptive, retrospective study was carried out in 263 patients with a diagnosis of primary VUR who received endoscopic treatment with Vantris, at the Centro Habana Pediatric Hospital, between January 2011 and December 2020. Results: Female gender and females predominated. ages 5 to 9 years, the average age was 6.12 years. 52.47% of patients presented bilateral VUR. In total, 401 ureteral meatuses were injected, VUR grades III (34.16%) and IV (31.42%) predominated, 11.40% of the sample presented a complete double excretory system. Conclusions: The endoscopic treatment of VUR With the use of Vantris it is associated with few complications, the most frequent being minor. Late ureteral obstruction is the most serious complication.

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“…Recently developed injectable agents include polyacrylatepolyalcohol copolymer, polyacrylamide hydrogel, and small-size (80-120 µm) dextranomer/hyaluronic acid copolymer (116). Like PTFE and silicone, polyacrylate-polyalcohol copolymer and polyacrylamide hydrogel are non-biodegradable, meaning they can remain within the body permanently.…”

Section: Endoscopic Injectionmentioning

confidence: 99%

“…They both have a favorable histopathologic profile, but foreign-body reactions are possible (117)(118)(119)(120). Polyacrylate-polyalcohol copolymer has been associated with risks of periureteral fibrosis (potentially complicating subsequent ureteral reimplantation) and obstruction of the vesicoureteral junction (116,121). Comparative studies suggest that polyacrylatepolyalcohol copolymer, polyacrylamide hydrogel and small-size dextranomer/hyaluronic acid copolymer are at least as effective as NASHA/Dx in resolving VUR (106,(121)(122)(123)(124).…”

Section: Endoscopic Injectionmentioning

confidence: 99%

Management of Vesicoureteral Reflux: What Have We Learned Over the Last 20 Years?

et al. 2021

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Vesicoureteral reflux (VUR) is associated with increased risks of urinary tract infection, renal scarring and reflux nephropathy. We review advancements over the last two decades in our understanding and management of VUR. Over time, the condition may resolve spontaneously but it can persist for many years and bladder/bowel dysfunction is often involved. Some factors that increase the likelihood of persistence (e.g., high grade) also increase the risk of renal scarring. Voiding cystourethrography (VCUG) is generally considered the definitive method for diagnosing VUR, and helpful in determining the need for treatment. However, this procedure causes distress and radiation exposure. Therefore, strategies to reduce clinicians' reliance upon VCUG (e.g., after a VUR treatment procedure) have been developed. There are several options for managing patients with VUR. Observation is suitable only for patients at low risk of renal injury. Antibiotic prophylaxis can reduce the incidence of UTIs, but drawbacks such as antibiotic resistance and incomplete adherence mean that this option is not viable for long-term use. Long-term studies of endoscopic injection have helped us understand factors influencing use and the effectiveness of this procedure. Ureteral reimplantation is still performed commonly, and robot-assisted laparoscopic methods are gaining popularity. Over the last 20 years, there has been a shift toward more conservative management of VUR with an individualized, risk-based approach. For continued treatment improvement, better identification of children at risk of renal scarring, robust evidence regarding the available interventions, and an improved VUR grading system are needed.

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A review of novel STING bulking agents

Cited by 13 publications

References 23 publications

A Rare Case of Actinomyces odontolyticus Infection after Injection Laryngoplasty with Deflux

A Rare Case of Actinomyces odontolyticus Infection after Injection Laryngoplasty with Deflux

Complications of Endoscopic Treatment With Vantris in Primary Vesicoureteral Reflux in Childhood

Management of Vesicoureteral Reflux: What Have We Learned Over the Last 20 Years?

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