“…Among the brain areas most consistently related in previous work to stressorâevoked cardiovascular reactivityâas well as some markers of autonomic cardiovascular control, inflammation, and arterial markers of preclinical vascular diseaseâare areas within the medial prefrontal cortex, anterior cingulate cortex, insula, extended amygdala, hippocampus, and hindbrain and brainstem cell groups 1, 13, 16. It has been proposed that signaling patterns between these areas may serve to calibrate the magnitude of physiological (eg, cardiovascular) reactions to anticipated selfârelevant demands (eg, stressors) to support contextually adaptive behavioral coping processes 13, 46, 47. Moreover, an individual's propensity to exhibit â mis âcalibrationsâ between brain and physiological activity may reflect a dimension of individual difference that underlies the expression of âexaggeratedâ (metabolically excessive or pathophysiological) autonomic, inflammatory, and cardiovascular reactions, including stressorâevoked BP reactions that have been linked to preclinical CVD 46, 47, 48.…”