A review of negative symptom assessment strategies in youth at clinical high-risk for psychosis

Strauss, Gregory P.; Pelletier-Baldelli, Andrea; Visser, Katherine Frost; Walker, Elaine F.; Mittal, Vijay A.

doi:10.1016/j.schres.2020.04.019

Cited by 51 publications

(32 citation statements)

References 72 publications

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“…Negative symptoms, defined as decreases in emotion, motivation, and/or expressive behavior [ 38 ], are a feature of schizophrenia and the attenuated psychosis syndrome [ 39 ]. Studies confirm that negative symptoms predict a number of poor clinical outcomes and limit social and vocational attainment [ 40 , 41 , 42 ]. Negative symptoms are highly associated with functional results in subjects that meet UHR criteria [ 43 ].…”

Section: Discussionmentioning

confidence: 99%

The Relationship between PID-5 Personality Traits and Mental States. A Study on a Group of Young Adults at Risk of Psychotic Onset

et al. 2021

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Background and Objectives: The diagnosis of psychosis is a challenge for the scientific community, both in terms of its definition and treatment. Some recent studies have investigated the relationship between personality and psychosis onset to prevent or intervene early. Materials and Methods: Sixty young adults were recruited during their first access in 2019 near the Community Mental Health Service of Niguarda Hospital, Milan, Italy. The assessment included the Social and Occupational Functioning Assessment Scale (SOFAS), the Global Assessment of Functioning (GAF) (clinician scales), the 16-item Version of the Prodromal Questionnaire (PQ-16), the Personality Inventory for DSM-5 (PID-5) (self-report), and a clinical session. Statistical analysis was performed by SPSS. Results: The results show a negative correlation between the Detachment domain and the GAF scores. Correlational analysis also highlights that all PID-5 domains, except for Antagonism, have positive correlations with high scores in the PQ-16. The multivariate analysis of variance showed that patients diagnosed with versus without a psychotic disorder significantly differed on Detachment, Antagonism and Psychoticism PID-5 domains. Conclusions: The involvement of the personality construct in psychopathological development is displayed. In particular, higher levels of Detachment and Psychoticism can distinguish people who are more vulnerable to psychosis or who already have overt psychosis from those who do not have a psychotic predisposition. The study highlights the fundamental role of personality traits, emerging from PID-5, to distinguish young adults at risk of onset.

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Section: Discussionmentioning

confidence: 99%

The Relationship between PID-5 Personality Traits and Mental States. A Study on a Group of Young Adults at Risk of Psychotic Onset

et al. 2021

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“…It may still fail to adequately capture the subtleties of attenuated negative symptoms manifested in ARMS individuals. Development of a new rating instrument that specifically evaluates negative symptoms in young people with ARMS would facilitate comprehensive and more refined negative symptom assessment in at-risk populations (Strauss et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

“…Alternatively, it should be noted that negative symptoms are most commonly evaluated in ARMS studies by either diagnostic instruments used to verify ARMS status (e.g., Structured Interview for Prodromal Symptoms (Miller et al, 2003) and Comprehensive Assessment of At-Risk Mental State (Yung et al, 2005)) or by other symptom scales (e.g., Positive and Negative Syndrome Scale (PANSS; Kay et al, 1987)), with its symptom items not well aligned with current conceptualizations of the five core domains of negative symptoms (anhedonia, avolition, asociality, blunted affect and alogia) recognized by the NIMH Consensus Development Conference on Negative Symptoms (Kirkpatrick et al, 2006;Marder & Galderisi, 2017). This may compromise the comprehensiveness of negative symptom measurement in prior studies (Strauss et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Sex differences in symptom severity, cognition and psychosocial functioning among individuals with at‐risk mental state for psychosis

Chan

Chang

et al. 2021

Early Intervention Psych

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Aim: Sex differences are well documented in schizophrenia, but have been much less studied in at-risk mental state (ARMS) for psychosis. We aimed to examine sex differences in symptomatology, cognition, social and role functioning in individuals with ARMS, with specific focus on clarifying relationships between sex, negative symptoms and functioning.Methods: One hundred and seventy-seven Chinese participants aged 15-40 years with ARMS were recruited from a specialized early intervention service in Hong Kong. ARMS status was verified by Comprehensive Assessment of At-Risk Mental State. Assessments encompassing symptom profiles, a brief battery of cognitive tests and social and role functioning were conducted. Brief Negative Symptom Scale was adapted to measure negative symptoms at the level of five core domains.Results: Males with ARMS exhibited significantly poorer social functioning and more severe asociality of negative symptoms than female counterparts. Mediation analysis revealed that sex difference in social functioning became statistically insignificant when asocality was included in the model, indicating that asociality mediated the relationship between sex and social functioning. No sex differences were observed in other core domains of negative symptoms, other symptom dimensions, cognitive measures and role functioning.Conclusions: This study suggests that sex differences in ARMS may be less pronounced that those observed in established psychotic disorders. Our findings of differential pattern of asociality between sexes and its mediating role on sex difference in social functioning underscore the importance in investigating negative symptoms at a separable domain-level. Further research is required to identify sex-specific predictors of longitudinal outcomes in at-risk populations.

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“…Advances continue to be made in understanding environmental and neurobiological determinants and mechanisms of transiting from prodromal to manifest psychotic states. Negative ( Devoe et al, 2021 ) and cognitive symptom evaluation through validated instruments aim to supplement the existing ones that are skewed towards identifying positive psychotic symptoms in prodromal states ( Strauss et al, 2020 ). Inflammatory ( Kelsven et al, 2020 ; Perry et al, 2021 ), neurolinguistic ( Bilgrami et al, 2022 ; Spencer et al, 2021 ), frontocentral P300 amplitudes, and biochemical assays (erythrocyte sphingomyelin and phosphatidylethanolamine) ( Alqarni et al, 2020a , Alqarni et al, 2020b ), have shown promise as biomarkers of transition ( Park and Miller, 2020 ; Tang et al, 2020 ).…”

Section: Prodrome Early Intervention Biomarkers and Early Psychosismentioning

confidence: 99%

A redux of schizophrenia research in 2021

Suhas

Mehta

2022

Schizophrenia Research

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A review of negative symptom assessment strategies in youth at clinical high-risk for psychosis

Cited by 51 publications

References 72 publications

The Relationship between PID-5 Personality Traits and Mental States. A Study on a Group of Young Adults at Risk of Psychotic Onset

The Relationship between PID-5 Personality Traits and Mental States. A Study on a Group of Young Adults at Risk of Psychotic Onset

Sex differences in symptom severity, cognition and psychosocial functioning among individuals with at‐risk mental state for psychosis

A redux of schizophrenia research in 2021

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