A review of natural astaxanthin production in a circular bioeconomy context using Paracoccus carotinifaciens

Mussagy, Cassamo U.; Dufossé, Laurent

doi:10.1016/j.biortech.2022.128499

Cited by 15 publications

(8 citation statements)

References 43 publications

(57 reference statements)

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“…The market for astaxanthin is currently valued at around USD 647 million and is expected to grow at an annual rate of 8.3 to 16.8%, reaching USD 880-968 million by 2026. The main producers of astaxanthin are microalgae such as H. pluvialis and C. zofingiensis [39][40][41], yeast (P. rhodozyma and Rhodosporidium spp.) [39,42], easts such as P. rhodozyma and Rhodosporidium spp., as well as bacteria, includ-ing Paracoccus spp., Agrobacterium spp., Sphingomonas spp.…”

Section: Astaxantinementioning

confidence: 99%

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Natural Pigments Production and Their Application in Food, Health and Other Industries

et al. 2023

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In addition to fulfilling their function of giving color, many natural pigments are known as interesting bioactive compounds with potential health benefits. These compounds have various applications. In recent times, in the food industry, there has been a spread of natural pigment application in many fields, such as pharmacology and toxicology, in the textile and printing industry and in the dairy and fish industry, with almost all major natural pigment classes being used in at least one sector of the food industry. In this scenario, the cost-effective benefits for the industry will be welcome, but they will be obscured by the benefits for people. Obtaining easily usable, non-toxic, eco-sustainable, cheap and biodegradable pigments represents the future in which researchers should invest.

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Section: Astaxantinementioning

confidence: 99%

“…of 8.3 to 16.8%, reaching USD 880-968 million by 2026. The main producers of asta are microalgae such as H. pluvialis and C. zofingiensis [39][40][41], yeast (P. rhodozy Rhodosporidium spp.) [39,42], easts such as P. rhodozyma and Rhodosporidium spp., as bacteria, including Paracoccus spp., Agrobacterium spp., Sphingomonas spp.…”

Section: Astaxantinementioning

confidence: 99%

Natural Pigments Production and Their Application in Food, Health and Other Industries

et al. 2023

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“…A growing amount of research proves that carotenoid consumption would be beneficial not only for animal welfare but also to reduce the incidence of human chronic inflammatory diseases [ 32 ]. Taken together, these factors picture a complex present aimed to favor the rise of companies selling carotenoids produced and extracted from natural sources, encompassing the circular economy and genetically modified organisms [ 33 ].…”

Section: Carotenoids: Structure and Source Dietary Effects In Animals...mentioning

confidence: 99%

More Than Pigments: The Potential of Astaxanthin and Bacterioruberin-Based Nanomedicines

2023

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Carotenoids are natural products regulated by the food sector, currently used as feed dyes and as antioxidants in dietary supplements and composing functional foods for human consumption. Of the nearly one thousand carotenoids described to date, only retinoids, derived from beta carotene, have the status of a drug and are regulated by the pharmaceutical sector. In this review, we address a novel field: the transformation of xanthophylls, particularly the highly marketed astaxanthin and the practically unknown bacterioruberin, in therapeutic agents by altering their pharmacokinetics, biodistribution, and pharmacodynamics through their formulation as nanomedicines. The antioxidant activity of xanthophylls is mediated by routes different from those of the classical oral anti-inflammatory drugs such as corticosteroids and non-steroidal anti-inflammatory drugs (NSAIDs): remarkably, xanthophylls lack therapeutic activity but also lack toxicity. Formulated as nanomedicines, xanthophylls gain therapeutic activity by mechanisms other than increased bioavailability. Loaded into ad hoc tailored nanoparticles to protect their structure throughout storage and during gastrointestinal transit or skin penetration, xanthophylls can be targeted and delivered to selected inflamed cell groups, achieving a massive intracellular concentration after endocytosis of small doses of formulation. Most first reports showing the activities of oral and topical anti-inflammatory xanthophyll-based nanomedicines against chronic diseases such as inflammatory bowel disease, psoriasis, atopic dermatitis, and dry eye disease emerged between 2020 and 2023. Here we discuss in detail their preclinical performance, mostly targeted vesicular and polymeric nanoparticles, on cellular models and in vivo. The results, although preliminary, are auspicious enough to speculate upon their potential use for oral or topical administration in the treatment of chronic inflammatory diseases.

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“…Carotenoids are produced intracellularly in several microorganisms (Mussagy and Dufossé 2023 ). Consequently, apart from their high production levels, the primary issues related to employing microorganisms for carotenoid production involve the necessity of implementing additional extraction processes for the recovery of these intracellular pigments.…”

Section: Introductionmentioning

confidence: 99%

Tailor-made solvents for microbial carotenoids recovery

Mussagy,

Hucke,

Ramos

et al. 2024

Appl Microbiol Biotechnol

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In recent years, microbial carotenoids have emerged as a promising alternative for the pharmaceutical and food industries, particularly in promoting human health due to their potent antioxidant and antimicrobial properties. Microbial carotenoids, particularly those produced by yeast, bacteria, and microalgae, are synthesized intracellularly, requiring the use of solvents for their effective extraction and recovery. The conventional use of toxic volatile organic solvents (VOCs) like hexane, petroleum ether, and dimethyl sulfoxide in the extraction of microbial carotenoids has been common. However, ongoing research is introducing innovative, non-toxic, environmentally friendly tailor-made solvents, such as ionic liquids (IL) and deep eutectic solvents (DES), indicating a new era of cleaner and biocompatible technologies. This review aims to highlight recent advancements in utilizing IL and DES for obtaining carotenoids from microorganisms. Additionally, we explore the utilization of in silico tools designed to determine the solubilities of microbial carotenoids in tailor-made DES and ILs. This presents a promising alternative for the scientific community, potentially reducing the need for extensive experimental screening of solvents for the recovery of microbial carotenoids in the separation processing. According to our expert perspective, both IL and DES exhibit a plethora of exceptional attributes for the recovery of microbial carotenoids. Nevertheless, the current employment of these solvents for recovery of carotenoids is restricted to scientific exploration, as their feasibility for practical application in industrial settings has yet to be conclusively demonstrated. Key points • ILs and DES share many tailoring properties for the recovery of microbial carotenoids • The use of ILs and DES for microbial carotenoid extraction remains driven by scientific curiosity. • The economic feasibility of ILs and DES is yet to be demonstrated in industrial applications.

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A review of natural astaxanthin production in a circular bioeconomy context using Paracoccus carotinifaciens

Cited by 15 publications

References 43 publications

Natural Pigments Production and Their Application in Food, Health and Other Industries

Natural Pigments Production and Their Application in Food, Health and Other Industries

More Than Pigments: The Potential of Astaxanthin and Bacterioruberin-Based Nanomedicines

Tailor-made solvents for microbial carotenoids recovery

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