A review of nardosinone for pharmacological activities

Wen, Jiawei; Liu, Linqiu; Li, Junjun; He, Yang

doi:10.1016/j.ejphar.2021.174343

Cited by 9 publications

(8 citation statements)

References 69 publications

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“…Nardosinone is a nardosinane‐type sesquiterpene compound isolated from N. jatamanasi , and previous studies have shown that nardosinone is a major contributor to the diverse biological function of the herb (Wen et al, 2021). Regarding the effects on skeletal disorders, only the study by Niu et al (2017) has demonstrated that nardosinone can suppress RANKL‐induced osteoclastogenesis and attenuate lipopolysaccharide‐induced alveolar bone resorption, providing valuable information for further assessing the anti‐OA potential of nardosinone.…”

Section: Discussionmentioning

confidence: 99%

“…(Valerianaceae) is a medicinal plant that is widely used in different formulas of traditional medicine in China, India, and Korea for the treatment of epilepsy, toothache, indigestion, and heart disease (Li et al, 2019; Rehman & Ahmad, 2019; Wen et al, 2020). The studies regarding the pharmacological effects of N. jatamansi have shown that the plant is characterized by anti‐inflammatory, anti‐oxidant, anti‐cancer, neuroprotective, cardioprotective, and many more properties (Wen et al, 2021). Based on the findings of previous studies, N. jatamansi contains bioactive compounds such as 8α–hydroxypinoresinol, desoxo‐narchinol, nardosinonediol, and kanshone A, of which nardosinone (Figure 1) is a major active ingredient in N. jatamanasi with a sesquiterpenoid structure and has been proved to play important roles in the anti‐inflammatory, neuroprotective, cardioprotective and other potential pharmacological effects of N. jatamanasi (Du et al, 2013; Li et al, 2014; Niu et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

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Nardosinone suppresses monoiodoacetate‐induced osteoarthritis in rats: The key role of the miR‐218‐5p/NUMB axis

Luo²,

Zhang

2022

Chem Biol Drug Des

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Nardosinone is a bioactive compound with a sesquiterpenoid structure isolated from Nardostachys jatamansi. The compound has shown treatment effects against skeletal disorders. In the current study, the effects of nardosinone on osteoarthritis (OA) were first assessed and the mechanism underlying the effects was explored by detecting changes in the miR‐218‐5p/NUMB axis. The miR, as a potential target mediating the effects of nardosinone on OA, was first determined with microarray and RT‐qPCR detections. Then, OA symptoms were induced in rats using monoiodoacetate (MIA) and treated with nardosinone. The anti‐OA effects of nardosinone were assessed via the detection of the histological structure and inflammation. The role of miR‐218‐5p was delineated by modulating its levels in OA‐affected rats. Based on the results of microarray and RT‐qPCR detections, miR‐218‐5p was selected as the therapeutic target for nardosinone. The induction of OA resulted in tissue destruction and the production of cytokines in rat joint tissues, which was associated with the up‐regulation of miR‐218‐5p and the downregulation of NUMB. For OA‐affected rats treated with nardosinone, the joint structure was improved and the inflammatory response was suppressed, along with the restored expression levels of miR‐218‐5p and NUMB. The re‐induced level of miR‐218‐5p compromised the anti‐OA effects of nardosinone, indicating that the inhibition of the miR played an indispensable role in the anti‐OA function of nardosinone. Collectively, the findings of our study demonstrated that nardosinone exerts treatment effects against OA by modulating the miR‐218‐5p/NUMB axis. Future studies will provide more detailed information on the interaction between nardosinone and miR in the attenuation of OA.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Nardosinone suppresses monoiodoacetate‐induced osteoarthritis in rats: The key role of the miR‐218‐5p/NUMB axis

Luo²,

Zhang

2022

Chem Biol Drug Des

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“…Nardosinone is a sesquiterpene peroxide and exists in a variety of medicinal plants, such as Nardostachys jatamansi DC. [ 1 ], Millettia speciosa [ 2 ], Sargassum fusiforme [ 3 ], Taraxacum kok-saghyz Rodin [ 4 ], Chrysanthemum morifolium [ 5 ]. In addition, nardosinone was also detected in Mahuang Fuzi Xixin decoction [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

“…Pharmacological studies have shown that NRR has pharmacological effects of improving headaches, palpitations, and syncope [ 9 ], and it also has antioxidant, neuroprotective, antiepileptic, cardioprotective, anti-neuroinflammation, and other pharmacological activities [ 10 , 11 , 12 ]. Furthermore, NRR is mainly used in the form of compound prescription in clinical, e.g., Wenxin Granules can be used to treat premature ventricular contractions in patients with chronic heart failure [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

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Analysis of In Vivo Existence Forms of Nardosinone in Mice by UHPLC-Q-TOF-MS Technique

et al. 2022

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Nardosinone, a sesquiterpene peroxide, is one of the main active constituents of the ethnomedicine Nardostachyos Radix et Rhizoma, and it has many bioactivities, such as antiarrhythmia and cardioprotection. To elucidate its in vivo existence forms, its metabolism is first studied using mice. All urine and feces are collected during the six days of oral dosing of nardosinone, and blood is collected at one hour after the last dose. Besides, to validate some metabolites, a fast experiment is performed, in which nardosinone was orally administered and the subsequent one-hour urine is collected and immediately analyzed by UHPLC-Q-TOF-MS. In total, 76 new metabolites are identified in this study, including 39, 51, and 12 metabolites in urine, plasma, and feces, respectively. Nardosinone can be converted into nardosinone acid or its isomers. The metabolic reactions of nardosinone included hydroxylation, hydrogenation, dehydration, glucuronidation, sulfation, demethylation, and carboxylation. There are 56 and 20 metabolites with the structural skeleton of nardosinone and nardosinone acid, respectively. In total, 77 in vivo existence forms of nardosinone are found in mice. Nardosinone is mainly excreted in urine and is not detected in the feces. These findings will lay the foundation for further research of the in vivo effective forms of nardosinone and Nardostachyos Radix et Rhizoma.

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Natural Peroxides from Plants: Historical Discovery, Biosynthesis, and Biological Activities

Asmaey,

Hamed,

Shaaban

2024

Chemistry & Biodiversity

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Naturally occurring peroxides received great interest and attention from scientific research groups worldwide due to their structural diversity, versatile biological activities, and pharmaceutical properties. In the present review, we describe the historical discovery of natural peroxides from plants systematically and update the researchers with recently explored ones justifying their structural caterogrization and biological/pharmaceutical properties intensively. Till the end of 2023, 192 peroxy natural products from plants were documented herein for the first time implying most categories of natural scaffolds (e.g. terpenes, polyketides, phenolics and alkaloids). Numerically, the reported plants’ peroxides have been classified into seventy‐four hydro‐peroxides, hundred seven endo‐peroxides and eleven acyl‐peroxides. Endo‐peroxides (cyclic alkyl peroxides) are an important group due to their high variety of structural frameworks, and we have further divided them into “four‐, five‐, six and seven”‐membered rings. Biosynthetically, a shedding light on the intricate mechanisms behind the formation of plant‐derived peroxides are addressed as well.

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A review of nardosinone for pharmacological activities

Cited by 9 publications

References 69 publications

Nardosinone suppresses monoiodoacetate‐induced osteoarthritis in rats: The key role of the miR‐218‐5p/NUMB axis

Nardosinone suppresses monoiodoacetate‐induced osteoarthritis in rats: The key role of the miR‐218‐5p/NUMB axis

Analysis of In Vivo Existence Forms of Nardosinone in Mice by UHPLC-Q-TOF-MS Technique

Natural Peroxides from Plants: Historical Discovery, Biosynthesis, and Biological Activities

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