A Review of MDA-5 Dermatomyositis and Associated Interstitial Lung Disease
Sambhawana Bhandari,
Lisa Zickuhr,
Maun Ranjan Baral
et al.
Abstract:Anti-melanoma differentiation-associated gene 5 (MDA-5) dermatomyositis (DM) is noteworthy for its association with rapidly progressive interstitial lung disease (RP-ILD), vasculopathy, and distinctive cutaneous features. First identified in a Japanese cohort in 2005, MDA-5 DM carries a significant mortality risk, emphasizing the crucial need for early diagnosis. This review explores the pathogenesis, clinical presentation, diagnosis, management, and prognosis of MDA-5 DM and ILD and includes new research and … Show more
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