A Review of Machine Perfusion Strategies in Liver Transplantation

Banker, Amay; Bhatt, Neha; Rao, Prashantha; Agrawal, Pravin; Shah, Mitul; Nayak, Madhavi; Mohanka, Ravi

doi:10.1016/j.jceh.2022.08.001

Cited by 3 publications

(2 citation statements)

References 89 publications

(102 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Facing liver graft shortage and an increase in marginal liver grafts, researchers proposed several approaches to rehabilitate marginal grafts to improve patients' prognosis before and after LT. Recent studies based on animal models highlighted the potential role of normothermic machine perfusion (NMP) in shortening cold ischemia time, increasing organ preservation time, and optimizing organ rehabilitation and regeneration 29 . Among therapies tested during NMP, MSCs showed pleiotropic properties to attenuate most of the liver graft IRI in which inflammation plays a key role 30 .…”

Section: Mesenchymal Stromal Cells and Marginal Liver Grafts Rehabili...mentioning

confidence: 99%

Therapeutic potentials of mesenchymal stromal cells-derived extracellular vesicles in liver failure and marginal liver graft rehabilitation: a scoping review

et al. 2023

View full text Add to dashboard Cite

HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.

show abstract

Section: Mesenchymal Stromal Cells and Marginal Liver Grafts Rehabili...mentioning

confidence: 99%

Therapeutic potentials of mesenchymal stromal cells-derived extracellular vesicles in liver failure and marginal liver graft rehabilitation: a scoping review

et al. 2023

View full text Add to dashboard Cite

show abstract

“…As a result, transplantation becomes a race against time. In order to mitigate the negative effects of ischemia, efforts have focused on organ preservation by reducing cold ischemia time and implementing different organ perfusion techniques[ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

Association of donor hepatectomy time with liver transplantation outcomes: A multicenter retrospective study

Custodio,

Massutti,

Caramori

et al. 2024

World J Transplant

View full text Add to dashboard Cite

BACKGROUND Prolonged donor hepatectomy time may be implicated in early and late complications of liver transplantation. AIM To evaluate the impact of donor hepatectomy time on outcomes of liver transplant recipients, mainly early allograft dysfunction. METHODS This multicenter retrospective study included brain-dead donors and adult liver graft recipients. Donor-recipient matching was obtained through a crossover list. Clinical and laboratory data were recorded for both donors and recipients. Donor hepatectomy, cold ischemia, and warm ischemia times were recorded. Primary outcome was early allograft dysfunction. Secondary outcomes included need for retransplantation, length of intensive care unit and hospital stay, and patient and graft survival at 12 months. RESULTS From January 2019 to December 2021, a total of 243 patients underwent a liver transplant from a brain-dead donor. Of these, 57 (25%) developed early allograft dysfunction. The median donor hepatectomy time was 29 (23–40) min. Patients with early allograft dysfunction had a median hepatectomy time of 25 (22–38) min, whereas those without it had a median time of 30 (24–40) min (P = 0.126). CONCLUSION Donor hepatectomy time was not associated with early allograft dysfunction, graft survival, or patient survival following liver transplantation.

show abstract

MicroRNA-21 (miR-21) in breast cancer: From apoptosis dysregulation to therapeutic opportunities

Syed,

Banu,

Alshammrani

et al. 2024

Pathology - Research and Practice

View full text Add to dashboard Cite

A Review of Machine Perfusion Strategies in Liver Transplantation

Cited by 3 publications

References 89 publications

Therapeutic potentials of mesenchymal stromal cells-derived extracellular vesicles in liver failure and marginal liver graft rehabilitation: a scoping review

Therapeutic potentials of mesenchymal stromal cells-derived extracellular vesicles in liver failure and marginal liver graft rehabilitation: a scoping review

Association of donor hepatectomy time with liver transplantation outcomes: A multicenter retrospective study

MicroRNA-21 (miR-21) in breast cancer: From apoptosis dysregulation to therapeutic opportunities

Contact Info

Product

Resources

About