A review of linc00673 as a novel lncRNA for tumor regulation

Gong, Zhaojian; Li, Panchun; Jiang, Xianjie; Zeng, Zhaoyang; Wang, Xiong; Yu, Jianjun

doi:10.7150/ijms.48134

Cited by 15 publications

(7 citation statements)

References 73 publications

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“…These results were similar to the previous meta-analysis by Cao et al They reported that linc00673 demonstrated significantly prognostic value 38 . Similarly, Zhu in his literature review article explored that the high expression of linc00673, which acts as a pro-oncogene, is related to adverse outcomes for patients 39 . Moreover, our results showed that in patients with malignancy, the increased expression of linc00673 was associated with later T stage and tumour stage and an increased likelihood of lymph node metastasis and distant metastasis.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological and prognostic significance of LINC00673 in human malignancy: a review and meta-analysis

et al. 2021

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Background: We conducted this research to investigate the relationship between linc00673 expression and prognosis and clinicopathological parameters in human malignancies. Methods: The PubMed, Embase, WOS and CNKI databases were used to collect eligible research data before January 4, 2021. Meta-analysis was performed using Stata 12.0 software. Pooled ORs (odds ratios) or HRs (hazard ratios) and their 95% CIs were calculated to evaluate the association of linc00673 expression with survival outcomes and clinical parameters. Results: We finally included 17 articles and a total of 1539 cases for the meta-analysis. The results indicated that linc00673 was significantly correlated with T stage (P=0.006), tumour stage (P<0.001), lymph node metastasis (P<0.001), and distant metastasis ( P<0.001). In addition, the results suggested that elevated linc00673 expression predicted a poor overall survival time (P=0.034) and acted as an independent prognostic factor (P<0.001) for OS in patients with malignancy. Although potential evidence of publication bias was found in the studies on OS in relation to tumour stage in the multivariate analysis, the trim-and-fill analysis confirmed that the results remained stable. Conclusion: Overexpression of linc00673 was significantly correlated with shorter OS time in patients with malignant tumours. Moreover, the increased expression level of linc00673 was significantly correlated with T stage, tumour stage, lymph node metastasis, and distant metastasis. The results presented in this article revealed that linc00673 might be involved in the progression and invasion of malignancy and serve as a novel prognostic biomarker and potential therapeutic target for malignancy.

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Section: Discussionmentioning

confidence: 99%

Clinicopathological and prognostic significance of LINC00673 in human malignancy: a review and meta-analysis

et al. 2021

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“…We selected rs11655237 because this SNP was reported to be correlated with the risks of different cancer types [ 42 ]. Moreover, two other SNPs (rs6501551 and rs9914618) located in LINC00673 were selected based on their functional potential with RegulomeDB scores of <3 obtained from the RegulomeDB database.…”

Section: Methodsmentioning

confidence: 99%

Genetic Polymorphisms of lncRNA LINC00673 as Predictors of Hepatocellular Carcinoma Progression in an Elderly Population

Yuan

Yang

Lee

et al. 2022

IJMS

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Long noncoding (lnc)RNAs are reported to be key regulators of tumor progression, including hepatocellular carcinoma (HCC). The lncRNA long intergenic noncoding RNA 00673 (LINC00673) was indicated to play an important role in HCC progression, but the impacts of genetic variants (single-nucleotide polymorphisms, SNPs) of LINC00673 on HCC remain unclear. A TaqMan allelic discrimination assay was performed to analyze the genotypes of three tagging SNPs, viz., rs9914618 G > A, rs6501551 A > G, and rs11655237 C > T, of LINC00673 in 783 HCC patients and 1197 healthy subjects. Associations of functional SNPs of LINC00673 with HCC susceptibility and clinicopathologic variables were analyzed by logistic regression models. After stratification by confounding factor, we observed that elderly patients (≥60 years) with the LINC00673 rs9914618 A allele had an increased risk of developing HCC under a codominant model (p = 0.025) and dominant model (p = 0.047). Moreover, elderly patients carrying the GA + AA genotype of rs9914618 exhibited a higher risk of having lymph node metastasis compared to those who were homozygous for the major allele (p = 0.013). Genotype screening of rs9914618 in HCC cell lines showed that cells carrying the AA genotype expressed higher LINC00673 levels compared to the cells carrying the GG genotype. Further analyses of clinical datasets from the Cancer Genome Atlas (TCGA) showed that LINC00673 expressions were upregulated in HCC tissues compared to normal tissues, and were correlated with advanced clinical stages and poorer prognoses. In conclusions, our results suggested that the LINC00673 rs9914618 polymorphism may be a promising HCC biomarker, especially in elderly populations.

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“…Authors have demonstrated that smokers are more susceptible to the risk of lymphatic spread, whereas, LINC00673 and rs9914618 single-nucleotide-polymorphism (SNP) are associated with tumour progression in the case of betel nut chewing or smoking in OSCC [ 130 ]. The higher expression of LINC00673 represents a positive correlation with tumour size, higher TNM staging, and also with recurrence, irrespective of risk factors in OSCC [ 131 ]. The upregulation of HIFCAR is seen in OSCC and it is correlated with advanced tumour staging and so, it acts as a prognostic biomarker.…”

Section: Functional Dysregulation Of Lncrnas In Oral Squamous Cell Ca...mentioning

confidence: 99%

Circulating Long Non-Coding RNAs Could Be the Potential Prognostic Biomarker for Liquid Biopsy for the Clinical Management of Oral Squamous Cell Carcinoma

Ghosh

Majumder²

2022

Cancers

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Long non-coding RNA (lncRNA) have little or no coding potential. These transcripts are longer than 200 nucleotides. Since lncRNAs are master regulators of almost all biological processes, recent evidence proves that aberrantly expressed lncRNAs are pathogenic for oral squamous cell carcinoma (OSCC) and other diseases. LncRNAs influence chromatin modifications, transcriptional modifications, post-transcriptional modifications, genomic imprinting, cell proliferation, invasion, metastasis, and apoptosis. Consequently, they have an impact on the disease transformation, progression, and morbidity in OSCC. Therefore, circulating lncRNAs could be the potential cancer biomarker for the better clinical management (diagnosis, prognosis, and monitoring) of OSCC to provide advanced treatment strategies and clinical decisions. In this review, we report and discuss the recent understandings and perceptions of dysregulated lncRNAs with a focus on their clinical significance in OSCC-disease monitoring and treatment. Evidence clearly indicates that a specific lncRNA expression signature could act as an indicator for the early prediction of diagnosis and prognosis for the initiation, progression, recurrence, metastasis and other clinical prognostic-factors (overall survival, disease-free survival, etc.) in OSCC. The present review demonstrates the current knowledge that all potential lncRNA expression signatures are molecular biomarkers for the early prediction of prognosis in OSCC. Finally, the review provides information about the clinical significance, challenges and limitations of the clinical usage of circulating lncRNAs in a liquid biopsy method in early, pre-symptomatic, sub-clinical, accurate OSCC prognostication. More studies on lncRNA are required to unveil the biology of the inherent mechanisms involved in the process of the development of differential prognostic outcomes in OSCC.

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A review of linc00673 as a novel lncRNA for tumor regulation

Cited by 15 publications

References 73 publications

Clinicopathological and prognostic significance of LINC00673 in human malignancy: a review and meta-analysis

Clinicopathological and prognostic significance of LINC00673 in human malignancy: a review and meta-analysis

Genetic Polymorphisms of lncRNA LINC00673 as Predictors of Hepatocellular Carcinoma Progression in an Elderly Population

Circulating Long Non-Coding RNAs Could Be the Potential Prognostic Biomarker for Liquid Biopsy for the Clinical Management of Oral Squamous Cell Carcinoma

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