A Review of Keratin-Based Biomaterials for Biomedical Applications

Abstract

Advances in the extraction, purification, and characterization of keratin proteins from hair and wool fibers over the past century have led to the development of a keratin-based biomaterials platform. Like many naturally-derived biomolecules, keratins have intrinsic biological activity and biocompatibility. In addition, extracted keratins are capable of forming self-assembled structures that regulate cellular recognition and behavior. These qualities have led to the development of keratin biomaterials with applications in wound healing, drug delivery, tissue engineering, trauma and medical devices. This review discusses the history of keratin research and the advancement of keratin biomaterials for biomedical applications.

Structure and mechanical properties of selected protective systems in marine organisms

“…Keratin is an integral element in the outer covering of many vertebrates and is commonly found in skin, hair, nails, beaks, turtle shells and hagfish slime [30][31][32]. There are two types of keratin: α-keratin (Fig.…”

Effect of Wool Keratin on Mechanical and Morphological Characteristics of Polycaprolactone Suture Fibre

“…Keratins extracted from mammalian fibres are fibrous structural proteins and exhibit a variety of useful biological characteristics such as strong biocompatibility and cell proliferation [8]. However, mechanical strength and surface morphology are critical in determining the ultimate performance of a surgical fibre.…”

Synthesis of Wound-Healing Keratin Hydrogels Using Chicken Feathers Proteins and Its Properties

“…A more extensive band of the hydroxyl group was the after effect of sol-gel responses. Utilitarian groups of amines and nitro speaks to the attributes of keratin [38]. H-PEG hydrogel has more hydrogen bonding contrasted with others and reasonable for topical application.…”