A review of isolation methods, structure features and bioactivities of polysaccharides from Dendrobium species

Han, Yuanyuan; Zeng, Hui; Ding, Kan

doi:10.1016/s1875-5364(20)30001-7

Cited by 36 publications

(28 citation statements)

References 103 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several studies have shown that DOP can stimulate the proliferation of splenocytes, and secrete cytokines IL-2 and IL-4, to induce morphological changes of macrophages, thus promoting the production of cytokines TNF-α, IL-6, IL-1 β, and NO. Further, they enhance the phagocytic activity of RAW267.4 macrophages and significantly enhance the killing activity of NK cells, which may be involved in the early immune response (Xia et al, 2012;He et al, 2016;Yue et al, 2020). In addition, it was observed that DOP could inhibit the growth of tumor cells in mice with sarcoma 180 cells, which can be related to its mechanism (Yue et al, 2020).…”

Section: Dendrobium Polysaccharidesmentioning

confidence: 96%

“…Researchers compared different kinds of Dendrobium from different producing areas and found that most of the crude polysaccharides or purified polysaccharides extracted from Dendrobium plants can enhance the function of immune cells, increase the secretion of cytokines, activate macrophages. In particular, the polysaccharides extracted from Dendrobium officinale polysaccharide (DOP) and Dendrobium huoshanense polysaccharide (DHP) have better immunomodulatory activity (Meng et al, 2013;Yue et al, 2020).…”

Section: Dendrobium Polysaccharidesmentioning

confidence: 99%

“…Further, they enhance the phagocytic activity of RAW267.4 macrophages and significantly enhance the killing activity of NK cells, which may be involved in the early immune response (Xia et al, 2012;He et al, 2016;Yue et al, 2020). In addition, it was observed that DOP could inhibit the growth of tumor cells in mice with sarcoma 180 cells, which can be related to its mechanism (Yue et al, 2020). Liang et al (2019) found in the colorectal cancer model that DOP can enhance the metabolic ability of tumor infiltrating CD8 + CTL, reduce the loss of mitochondria the expression of PD-1 on CTL, thus enhancing the anti-tumor immune response of TME.…”

Section: Dendrobium Polysaccharidesmentioning

confidence: 99%

“…Compared with free GLP, GLP-Au-induced CD80, CD86, CD40, and MHCII increased in a dose-dependent manner, and had a better immunostimulatory effect on DC maturation, with a statistically significant difference (Zhang et al, 2019). In addition, combining polysaccharides with liposomes (Huang Y. et al, 2016), or changing their properties to increase acetyl groups (Yue et al, 2020), or combining with proteins to form polypeptide compounds (Chen et al, 2009a) can improve their medicinal efficiency to varying degrees. Last but not least, it's of vital for polysaccharides with the presence of triple-helix conformation of (β1→3)-D-glucans, function groups, branching degree of pectic polysaccharides, and Type II arabinogalactans to enhance immunostimulatory activity.…”

Section: Summary and Perspectivesmentioning

confidence: 99%

See 3 more Smart Citations

Natural Polysaccharides and Their Derivates: A Promising Natural Adjuvant for Tumor Immunotherapy

Wang

et al. 2021

Front. Pharmacol.

View full text Add to dashboard Cite

The treatment process of tumor is advanced with the development of immunotherapy. In clinical experience, immunotherapy has achieved very significant results. However, the application of immunotherapy is limited by a variety of immune microenvironment. For a long time in the past, polysaccharides such as lentinan and Ganoderma lucidum glycopeptide have been used in clinic as adjuvant drugs to widely improve the immunity of the body. However, their mechanism in tumor immunotherapy has not been deeply discussed. Studies have shown that natural polysaccharides can stimulate innate immunity by activating upstream immune cells so as to regulate adaptive immune pathways such as T cells and improve the effect of immunotherapy, suggesting that polysaccharides also have a promising future in cancer therapy. This review systematically discusses that polysaccharides can directly or indirectly activate macrophages, dendritic cells, natural killer cells etc., binding to their surface receptors, inducing PI3K/Akt, mitogen-activated protein kinase, Notch and other pathways, promote their proliferation and differentiation, increasing the secretion of cytokines, and improve the state of immune suppression. These results provide relevant basis for guiding polysaccharide to be used as adjuvants of cancer immunotherapy.

show abstract

Section: Dendrobium Polysaccharidesmentioning

confidence: 96%

Section: Dendrobium Polysaccharidesmentioning

confidence: 99%

Section: Dendrobium Polysaccharidesmentioning

confidence: 99%

Section: Summary and Perspectivesmentioning

confidence: 99%

See 2 more Smart Citations

Natural Polysaccharides and Their Derivates: A Promising Natural Adjuvant for Tumor Immunotherapy

Wang

et al. 2021

Front. Pharmacol.

View full text Add to dashboard Cite

show abstract

“…12 For example, peptidyl nucleoside milbemycin (►Fig. 1), produced by Streptomyces rimofaciens, shows antimicrobial activities through inhibiting protein synthesis. 13,14 Sinefungin, the Sadenosyl-L-methionine analog, was proved to have inhibitory activities against fungi, viruses, and trypanosomal pathogens.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Natural Product-Like Tricyclic Higher-Carbon Sugar Nucleosides

Yuan

Wang

et al. 2021

Pharmaceutical Fronts

View full text Add to dashboard Cite

Because of the structural novelty and interesting biological profiles, the synthesis of higher-carbon sugars has been highly pursued. In this work, we first synthesized a series of structurally novel bis-uracil containing tricyclic higher-carbon sugar nucleosides (4a–e) using D-xylose as the starting material and the classical Vorbruggen glycosylation as the key synthetic step. The yields of the target compound were good. Unfortunately, despite the presence of pharmaceutically relevant uracil fragment, compounds 4a–e were inactive against the proliferation of several cancer cell lines (EC109, EC9706, PC-3, and MGC-803). Whether and how 4a–e functioned as anticancer agents would be further studied in our laboratory.

show abstract

Dendrobium officinale polysaccharides—chemical properties and pharmacodynamic effects on the airways in experimental conditions

Šutovská,

Mažerik,

Kocmálová

et al. 2023

Archiv der Pharmazie

View full text Add to dashboard Cite

The study aimed to analyze the effects of Dendrobium polysaccharides on the cough and airway reactivity and compare them with the effects of clinically used antitussives (codeine phosphate and butamirate citrate) and bronchodilators (salbutamol), using the guinea pig test system. Dendrobium officinale polysaccharides contained proteins (4.0 wt%) and phenolic compounds (1.7 wt%) with a molecular weight of 25,000 g/mol. The sugar analysis revealed a dominance of glucose (93.7 wt%) and a lesser amount of mannose (5.1 wt%) while other sugar quantities were negligible. Methylation analysis indicated the presence of highly branched polysaccharides. Glucose was found mainly as terminal, 1,4‐ and 1,6‐linked. Furthermore, some 1,4‐ and 1,6‐linked glucose units were found branched at O2, O3, and O6/O4. Mannose was terminal and 1,4‐linked. NMR spectra signals indicate the presence of the (1→4)‐linked α‐d‐glucan, (1→4)‐linked β‐d‐glucan branched at position O6, (1→6)‐linked β‐d‐glucan branched at position O3 and (1→4)‐linked glucomannan. Pharmacological studies showed statistically significant antitussive activity of Dendrobium polysaccharides, exceeding the effect of clinically used antitussives, which may be partially associated with confirmed bronchodilation and the ability of polysaccharides to increase the threshold of cough receptor activation. Dendrobium polysaccharides may increase the possibility of symptomatic treatment of cough, especially in asthmatics.

show abstract

A review of isolation methods, structure features and bioactivities of polysaccharides from Dendrobium species

Cited by 36 publications

References 103 publications

Natural Polysaccharides and Their Derivates: A Promising Natural Adjuvant for Tumor Immunotherapy

Natural Polysaccharides and Their Derivates: A Promising Natural Adjuvant for Tumor Immunotherapy

Synthesis of Natural Product-Like Tricyclic Higher-Carbon Sugar Nucleosides

Dendrobium officinale polysaccharides—chemical properties and pharmacodynamic effects on the airways in experimental conditions

Contact Info

Product

Resources

About