A review of ion-sensitive field effect transistor (ISFET) based biosensors.

Abstract

The invention of sensors that can identify and measure biomolecules is a crucial advancement for biology. Sensors have become widely used in several industries during the last few decades, most notably in the area of medical diagnosis. Biosensors constitute a bio-detecting system by integrating signal conversion and biological recognition components. They have been developed for a wide range of bio-detecting applications. A class of biosensors known as electrochemical biosensors uses electroanalytical equipment and has the advantages of higher sensitivity, simplicity, speed, and biomolecule recognition selectivity. One of the most popular electrochemical biosensors nowadays is the ISFET sensor, which performs biochemical measuring and biomolecule recognition. ISFETs, which were first suggested a little over fifty years ago, now the most promising devices for care diagnostics and lab on a chip are made with ISFETs. In this review paper, the history, working principles, fabrication processes, and modeling and simulation techniques of ISFET are presented. Additionally, some physical aspects and simulation methodologies are explained. Finally, we discuss their applications in sensitively and reliably analyzing diverse biomolecules, including DNA, enzymes, and cells.

Concept and Realisation of ISFET-Based Measurement Modules for Infield Soil Nutrient Analysis and Hydroponic Systems

“…This can also be seen in the manufacturers. There is now a very wide range of applications for the commercially available ISFET-based instruments in environmental monitoring, medicine and agriculture [58,59]. The results of the research carried out demonstrated the potential of ISFET technology for use in agricultural applications in addition to those already identified.…”