A Review of Intra‐Epithelial Carcinoma of the Uterine Cervix in New South Wales

Abstract

Summary: Age specific incidence rates of non‐invasive and invasive cancer for 1963 are reviewed. Comparative figures for non‐invasive (506 patients) and invasive cancer (1,679 patients) from 1955 to 1964, inclusive, are given. Results of diagnosis by Papanicolaou smear are analysed, with surprise positive and false negative rates. Results of colposcopic examinations are given, including false negative rate and pick‐up rate for false negative Papanicolaou smear. Association of marital status, motherhood, and pregnancy with non‐invasive cancer is given. Methods of treatment of intra‐epithelial cancer are given and a comparison is drawn between the periods 1955‐60 and 1961‐64. Follow‐up figures are analysed with a brief review of causes of death. A histological review of 71 sections according to the definitions of the Vienna Committee on Terminology showed that only 65% were considered to be noninvasive, 28% were thought to be benign dysplasia and 7% were classified as invasive (Stage 1a). A description of treatment and follow‐up of the latter group of patients is given.

Comparative study of histologic and chromosomal abnormalities in cervical neoplasia

“…This is particularly important in cases of carcinoma in situ and dysplasia, the diagnoses of which are notoriously unstable; diagnostic agreement for these seldom is achieved in more than 60% of cases.16, 17, 23 …”