Abstract:Intravenous and intra-arterial thrombolysis (IVT and IAT, respectively) are the two major therapeutic options for management of acute ischemic stroke (AIS). However, the FDA has only approved IVT for management of AIS, when the patient presents within 0-4.5 hours of AIS onset. This recommendation was based on numerous randomized controlled trials (RCT) which, when analyzed together, showed a net benefit towards the use of IVT. But a narrow therapeutic window, which is rarely met by the individual, and the rela… Show more
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