A Review of Innovations in Rhegmatogenous Retinal Detachment Surgical Techniques

Nemet, Achia; Moshiri, Ala; Yiu, Glenn; Loewenstein, Anat; Moisseiev, Elad

doi:10.1155/2017/4310643

Cited by 63 publications

(55 citation statements)

References 39 publications

(42 reference statements)

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“…Rhegmatogenous retinal detachment (RRD) refers to the detachment of the retinal neuroepithelial fiber layer from the retinal pigment epithelium (RPE) layer caused by the positioning of the vitreous body underneath the retinal neuroepithelial layer (1)(2)(3). The vitreous body may cause retinal tearing and the resulting tension may separate the retina from the RPE (4,5).…”

Section: Introductionmentioning

confidence: 99%

IL-10 inhibits retinal pigment epithelium cell proliferation and migration through regulation of VEGF in rhegmatogenous retinal detachment

Zhao

Wang

2018

Mol Med Report

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Rhegmatogenous retinal detachment (RRD) is a disorder of the eye that affects physical and mental health. Retinal pigment epithelium (RPE) is closely associated with RRD, and it is hypothesized that RPE-secreted inflammatory cytokines may induce early pathological changes of RRD and may participate in RPE proliferation and migration. The present study determined a role for interleukin (IL)‑10 as an RPE‑secreted immune regulatory factor that contributes to RRD. A rat RRD model was established and RPE cells were isolated and cultivated. RPE cells were randomly divided into four groups, three treated with different concentrations of IL‑10 (100, 50, and 20 mM) and one untreated. RPE cell proliferation was evaluated by MTT assay and the activity of caspase‑3 was also measured. RPE cell invasion was determined by Transwell assay. Vascular endothelial growth factor A (VEGF) expression was examined by reverse transcription‑quantitative polymerase chain reaction and western blotting; IL‑1 and IL‑6 levels were measured by ELISA. IL‑10 treatment suppressed RPE cell proliferation and migration, promoted caspase‑3 activity, inhibited VEGF mRNA and protein expression, and downregulated the secretion of inflammatory cytokines IL‑1 and IL‑6 in RRD group compared with the untreated Model group. The aforementioned effects of IL‑10 became more evident with increasing IL‑10 concentration. IL‑10 suppressed inflammation, facilitated RPE cell apoptosis and inhibited cell proliferation and migration through the regulation of VEGF expression.

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Section: Introductionmentioning

confidence: 99%

IL-10 inhibits retinal pigment epithelium cell proliferation and migration through regulation of VEGF in rhegmatogenous retinal detachment

Zhao

Wang

2018

Mol Med Report

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“…1 To reattach the detached retina and prevent further detachment, various treatments can be performed, including vitrectomy, scleral buckling, a combination of the two, pneumatic retinopexy, laser coagulation, or cryocoagulation. 2,3 However, even after successful anatomic reattachment, the functional results show a wide range of visual outcomes. Poor visual acuity, permanent functional damage, persistent metamorphopsia, and color vision defects can remain after surgery, especially in cases with macular involvement.…”

mentioning

confidence: 99%

Changes in Retinal Vessel and Retinal Layer Thickness After Vitrectomy in Retinal Detachment via Swept-Source OCT Angiography

Hong

Cho

Kim

et al. 2020

Invest. Ophthalmol. Vis. Sci.

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Citation: Hong EH, Cho H, Kim DR, Kang MH, Shin YU, Seong M. Changes in retinal vessel and retinal layer thickness after vitrectomy in retinal detachment via swept-source OCT angiography. Invest Ophthalmol Vis Sci. 2020;61(2):35. https://doi.org/10.1167/iovs.61.2.35 PURPOSE.To compare postvitrectomy retinal and choroidal vessel density (VD) and retinal layer thickness between eyes with macula-off and macula-on rhegmatogenous retinal detachment (RRD) using swept-source optical coherence tomography (SS-OCT) and optical coherence tomography angiography (OCTA) and to identify OCTA factors associated with visual outcomes. METHODS.We retrospectively reviewed 31 eyes that underwent pars plana vitrectomy for primary RRD. Eyes with macula-off and macula-on RRD were compared with healthy fellow eyes. Both OCT and OCTA were performed 6 months after surgery, and the maculaoff RRD group was divided into two subgroups according to the presence of an outer retinal defect. The correlations between postoperative best-corrected visual acuity (BCVA) at 6 months and SS-OCT and OCTA measurements were analyzed. RESULTS.Twenty eyes with macula-off RRD and 11 eyes with macula-on RRD were included. In the macula-off RRD group, the central retinal thickness was significantly decreased 6 months postoperatively compared with the fellow eyes (228.9 ± 29.7 μm and 253.6 ± 27.7 μm, P = 0.009). In the outer retinal defect group, the choriocapillaris plexus (CCP) VD was significantly decreased compared with the fellow eyes (56.4% ± 4.8% and 60.2% ± 4.0%, P = 0.026). In the macula-off RRD group, the postoperative BCVA at 6 months correlated significantly with the ratio of the center CCP VD of the detached eyes to that of the fellow eyes (R 2 = 0.207, P = 0.025). CONCLUSIONS.The CCP VD could be related to the anatomical restoration of the outer retinal layer in macula-off RRD. The CCP VD as determined by OCTA could be an indicator of the visual outcome after surgery in macula-off RRD.with macula-off and macula-on RRD using swept-source OCT (SS-OCT) and OCTA and to find OCTA factors related to postoperative visual outcomes.

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“…Significant advances of the surgical treatment of RRD have been made, and a variety of techniques are now available, with new instruments and modifications constantly being reported. However, further improvements are expected in the future [23,24].…”

Section: Discussionmentioning

confidence: 99%

Results of pars plana vitrectomy for primary rhegmatogenous retinal detachment with PVR grades A and B in high-myopic eyes

et al. 2019

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Purpose To evaluate the results of pars plana vitrectomy (PPV) without adjuvant buckling procedures for the primary rhegmatogenous retinal detachment (RRD) with PVR grades A and B in high-myopic eyes. Methods A retrospective review included 291 eyes treated for primary RRD from 2008 to 2016. The single surgery success rate (SSSR), the total number of surgeries, outcomes and complications were analysed between group of 67 eyes with high axial myopia (group A) and group of 224 eyes without high myopia (group B). Results The mean follow-up was 30.6 ± 22.8 months. The SSSR in group A was 82.1% and in group B was 86.2% (p [ 0.05). The final reattachment rate and number of required surgeries were in group A 96.3% (3.1 surgeries) and in group B 96.0% (2.8 surgeries). The initial BCVA improved in group A from 1.58 to 0.58 LogMAR at year 3; and in group B from 1.21 to 0.34 LogMAR. In match-pair analysis of macula-off RRD, no significant difference of the CRT between groups A and B was observed within 3 years of follow-up. Conclusion The anatomical success of primary PPV for RRD did not differ between high-myopic and nonhigh-myopic eyes in PVR grades A and B. However, functional results of high-myopic eyes are worse compared to eyes without high axial myopia.

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A Review of Innovations in Rhegmatogenous Retinal Detachment Surgical Techniques

Cited by 63 publications

References 39 publications

IL-10 inhibits retinal pigment epithelium cell proliferation and migration through regulation of VEGF in rhegmatogenous retinal detachment

IL-10 inhibits retinal pigment epithelium cell proliferation and migration through regulation of VEGF in rhegmatogenous retinal detachment

Changes in Retinal Vessel and Retinal Layer Thickness After Vitrectomy in Retinal Detachment via Swept-Source OCT Angiography

Results of pars plana vitrectomy for primary rhegmatogenous retinal detachment with PVR grades A and B in high-myopic eyes

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