A review of improved fixation methods for dental implants. Part II: Biomechanical integrity at bone–implant interface

Shibata, Yo; Tanimoto, Yasuhiro; Maruyama, Noriko; Nagakura, Manamu

doi:10.1016/j.jpor.2015.01.003

Cited by 52 publications

(36 citation statements)

References 100 publications

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“…Young's modulus is often assumed to be 1370 MPa for normal cancellous bone and 13 700 MPa for cortical bone of the mandible, 32 so these values were used to simulate high-density cancellous and cortical bone, respectively. To simulate low-density cancellous bone, Young's modulus was assumed to be 259 MPa based on preoperative patient data.…”

Section: Materials Propertiesmentioning

confidence: 99%

Micromotion analysis of different implant configuration, bone density, and crestal cortical bone thickness in immediately loaded mandibular full‐arch implant restorations: A nonlinear finite element study

Sugiura

Yamamoto

Horita

et al. 2017

Clin Implant Dent Rel Res

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Section: Materials Propertiesmentioning

confidence: 99%

Micromotion analysis of different implant configuration, bone density, and crestal cortical bone thickness in immediately loaded mandibular full‐arch implant restorations: A nonlinear finite element study

Sugiura

Yamamoto

Horita

et al. 2017

Clin Implant Dent Rel Res

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“…1 A number of nanomaterials have been produced to induce various biological functions in vivo. 2,3 However, the majority of the work only focuses on the biological effects of nanomaterials while their intrinsic immunomodulatory effects are often neglected. [4][5][6] Take the bone implant materials: for example, titanium (Ti) metal is extensively used in clinical practice due to its outstanding osseointegration ability.…”

Section: Introductionmentioning

confidence: 99%

Nanostructured titanium regulates osseointegration via influencing macrophage polarization in the osteogenic environment

Wang¹,

Meng²,

Song³

et al. 2018

IJN

101

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IntroductionFabricating nanostructured surface topography represents the mainstream approach to induce osteogenesis for the next-generation bone implant. In the past, the bone implant was designed to minimize host repulsive reactions in order to acquire biocompatibility. However, increasing reports indicate that the absence of an appropriate immune response cannot acquire adequate osseointegration after implantation in vivo.Materials and methodsWe prepared different topographies on the surface of titanium (Ti) specimens by grinding, etching and anodizing, and they were marked as polished specimen (P), specimen with nanotubes (NTs) in small diameters (NT-30) and specimen with NTs in large diameters (NT-100). We evaluated the ability of different topographies of the specimen to induce osteogenic differentiation of mice bone marrow mesenchymal stem cells (BMSCs) in vitro and to induce osseointegration in vivo. Furthermore, we investigated the effect of different topographies on the polarization and secretion of macrophages, and the effect of macrophage polarization on topography-induced osteogenic differentiation of mice BMSCs. Finally, we verified the effect of macrophage polarization on topography-induced osseointegration in vivo by using Cre*RBP-Jfl/fl mice in which classically activated macrophage was restrained.ResultsThe osteogenic differentiation of mice BMSCs induced by specimen with different topographies was NT-100>NT-30>P, while the osseointegration induced by specimen with different topographies in vivo was NT-30>NT-100>P. In addition, specimen of NT-30 could induce more macrophages to M2 polarization, while specimen of P and NT-100 could induce more macrophages to M1 polarization. When co-culture mice BMSCs and macrophages on specimen with different topographies, the osteogenic differentiation of mice BMSCs was NT-30>NT-100≥P. The osseointegration induced by NT-100 in Cre*RBP-Jfl/fl mice was much better than that of wild type mice.ConclusionIt is suggested that the intrinsic immunomodulatory effects of nanomaterials are not only crucial to evaluate the in vivo biocompatibility but also required to determine the final osseointegration. To clarify the immune response and osseointegration may be beneficial for the designation and optimization of the bone implant.

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“…Other approaches have involved improving the interface between the implant and the peri-implant bone tissue. Implant materials and/or implant surface treatments have been developed to augment cell adhesion and protein adsorption at the implant-bone tissue interface [10,11]. Ogawa [12] reported that titanium surfaces treated with ultraviolet light developed a unique electrostatic status and acted as direct cell attractants to effectively reduce the osseointegration period without the aid of ionic or organic bridges, which is a novel physicochemical characteristic of titanium [13].…”

Section: Introductionmentioning

confidence: 99%

Effect of a dietary supplement on peri-implant bone strength in a rat model of osteoporosis

Takahashi

Watanabe

Tanimoto

et al. 2016

Journal of Prosthodontic Research

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Purpose Osteoporosis contributes to impaired bone regeneration and remodeling through an imbalance of osteoblastic and osteoclastic activity, and can delay peri-implant bone formation after dental implant surgery, resulting in a prolonged treatment period. It poses several difficulties for individuals with large edentulous areas, and decreases their quality of life. Consequently, prompt postoperative placement of the final prosthesis is very important clinically. Peri-implant bone formation may be enhanced by systemic approaches, such as the use of osteoporosis supplements, to promote bone metabolism. We aimed to confirm whether intake of synthetic bone mineral (SBM), a supplement developed for osteoporosis, could effectively accelerate peri-implant bone formation in a rat model of osteoporosis. Methods Thirty-six 7-week-old ovariectomized female Wistar rats were randomly assigned to receive a standardized diet with or without SBM (Diet with SBM group and Diet without SBM group, respectively; n = 18 for both). The rats underwent implant surgery at 9 weeks of age under general anesthesia. The main outcome measures, bone mineral density (BMD) and pull-out strength of the implant from the femur, were compared at 2 and 4 weeks after implantation using the Mann-Whitney U test. Results Pull-out strength and BMD in the Diet with SBM group were significantly greater than those in the Diet without SBM group at 2 and 4 weeks after implantation. Conclusions This study demonstrated that SBM could be effective in accelerating peri-implant bone formation in osteoporosis.

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A review of improved fixation methods for dental implants. Part II: Biomechanical integrity at bone–implant interface

Cited by 52 publications

References 100 publications

Micromotion analysis of different implant configuration, bone density, and crestal cortical bone thickness in immediately loaded mandibular full‐arch implant restorations: A nonlinear finite element study

Micromotion analysis of different implant configuration, bone density, and crestal cortical bone thickness in immediately loaded mandibular full‐arch implant restorations: A nonlinear finite element study

Nanostructured titanium regulates osseointegration via influencing macrophage polarization in the osteogenic environment

Effect of a dietary supplement on peri-implant bone strength in a rat model of osteoporosis

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