A Review of Hyperacusis and Future Directions: Part I. Definitions and Manifestations

Tyler, Richard S.; Pienkowski, Martin; Rojas-Roncancio, Eveling; Jun, Hyung Jin; Brozoski, Tom; Dauman, Nicolas; Coelho, Clarisse Simões; Andersson, Gerhard; Keiner, Andrew J.; Cacace, Anthony T.; Martin, Nora; Moore, Brian C. J.

doi:10.1044/2014_aja-14-0010

Cited by 245 publications

(265 citation statements)

References 155 publications

(143 reference statements)

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“…Interestingly, Tlr2 mRNA expression was significantly upregulated at 14 days post-exposure, but not at 28 day post-exposure when Ntrk1 mRNA expression was upregulated. These results suggest that the failure to upregulate Ntrk1 following noise-induced damage and/or the loss of regulation on toll-like receptor could conceivably cause moderately intense sounds to be perceived as painful loud (Ades et al, 1959; Tyler et al, 2014b). …”

Section: Discussionmentioning

confidence: 99%

“…Intense sounds are not only perceived as painfully loud (Ades et al, 1959), but can also induce pain sensations in around the external ear (otalgia; Dominguez et al, 2006; Hebert et al, 2013; Henry et al, 2014; Kaltenbach et al, 2000; Knipper et al, 2013; McFerran and Baguley, 2007; Norena, 2011; Pienkowski et al, 2014; Tyler et al, 2014a; Van Campen et al, 1999; Westcott et al, 2013). Pain transmitting neuropeptides and receptors are present in the CN and auditory nerve (Aguilar et al, 2004; Bauer et al, 2007b; Jongkamonwiwat et al, 2003; Nguyen et al, 2014; Phansuwan-Pujito et al, 2003; Tongjaroenbuangam et al, 2006), raising the possibility that loud sounds may trigger the perception of pain through these signaling pathways.…”

Section: Introductionmentioning

confidence: 99%

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Noise-induced hearing loss: Neuropathic pain via Ntrk1 signaling

Manohar

Dahar

Adler

et al. 2016

Molecular and Cellular Neuroscience

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Severe noise-induced damage to the inner ear leads to auditory nerve fiber degeneration thereby reducing the neural input to the cochlear nucleus (CN). Paradoxically, this leads to a significant increase in spontaneous activity in the CN which has been linked to tinnitus, hyperacusis and ear pain. The biological mechanisms that lead to an increased spontaneous activity are largely unknown, but could arise from changes in glutamatergic or GABAergic neurotransmission or neuroinflammation. To test this hypothesis, we unilaterally exposed rats for 2 h to a 126 dB SPL narrow band noise centered at 12 kHz. Hearing loss measured by auditory brainstem responses exceeded 55 dB from 6 to 32 kHz. The mRNA from the exposed CN was harvested at 14 or 28 days post-exposure and qRT-PCR analysis was performed on 168 genes involved in neural inflammation, neuropathic pain and glutamatergic or GABAergic neurotransmission. Expression levels of mRNA of Slc17a6 and Gabrg3, involved in excitation and inhibition respectively, were significantly increased at 28 days post-exposure, suggesting a possible role in the CN spontaneous hyperactivity associated with tinnitus and hyperacusis. In the pain and inflammatory array, noise exposure up-regulated mRNA expression levels of four pain/inflammatory genes, Tlr2, Oprd1, Kcnq3 and Ntrk1 and decreased mRNA expression levels of two more genes, Ccl12 and Il1β. Pain/inflammatory gene expression changes via Ntrk1 signaling may induce sterile inflammation, neuropathic pain, microglial activation and migration of nerve fibers from the trigeminal nerve and cuneate and vestibular nuclei into the CN. These changes could contribute to somatic tinnitus, hyperacusis and otalgia.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Noise-induced hearing loss: Neuropathic pain via Ntrk1 signaling

Manohar

Dahar

Adler

et al. 2016

Molecular and Cellular Neuroscience

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“…Reactions are characteristically triggered by sounds in general, even at low intensities,[1] rather than to specific sounds as in misophonia. [2] However, misophonia as well as fear of sounds (phonophobia[34]) can occasionally appear together with hyperacusis[156] although the illnesses are not mutually inclusive. There are few population studies of hyperacusis, but prevalence rates of 8.6 and 15.2% have been reported from a Swedish[7] and Polish[8] study, respectively.…”

Section: Introductionmentioning

confidence: 99%

“…[4121314] To what extent individuals with hyperacusis in the general population cope with their condition by seeking medical attention lacks documentation to the best of our knowledge.…”

Section: Introductionmentioning

confidence: 99%

Characteristics of hyperacusis in the general population

2016

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There is a need for better understanding of various characteristics in hyperacusis in the general population. The objectives of the present study were to investigate individuals in the general population with hyperacusis regarding demographics, lifestyle, perceived general health and hearing ability, hyperacusis-specific characteristics and behavior, and comorbidity. Using data from a large-scale population-based questionnaire study, we investigated individuals with physician-diagnosed (n=66) and self-reported (n=313) hyperacusis in comparison to individuals without hyperacusis (n=2995). High age, female sex, and high education were associated with hyperacusis, and that trying to avoid sound sources, being able to affect the sound environment, and having sough medical attention were common reactions and behaviors. Posttraumatic stress disorder, chronic fatigue syndrome, generalized anxiety disorder, depression, exhaustion, fibromyalgia, irritable bowel syndrome, migraine, hearing impairment, tinnitus, and back/joint/muscle disorders were comorbid with hyperacusis. The results provide ground for future study of these characteristic features being risk factors for development of hyperacusis and/or consequences of hyperacusis.

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“…Hyperacusis is a loudness-related hypersensitivity to sounds that causes an experience of discomfort at lower loudness levels than normally. It encompasses a wide range of reactions to sound, which can be excessive loudness annoyance, fear or pain22. The current understanding is that hyperacusis results from the malfunction of the central auditory pathways and their connections within the central nervous system rather than the dysfunction at the peripheral level23, whereas the mechanisms underlying NS are less well-understood.…”

mentioning

confidence: 99%

A window into the brain mechanisms associated with noise sensitivity

Kliuchko

Heinonen-Guzejev

Vuust

et al. 2016

Sci Rep

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Noise sensitive individuals are more likely to experience negative emotions from unwanted sounds and they show greater susceptibility to adverse effects of noise on health. Noise sensitivity does not originate from dysfunctions of the peripheral auditory system, and it is thus far unknown whether and how it relates to abnormalities of auditory processing in the central nervous system. We conducted a combined electroencephalography and magnetoencephalography (M/EEG) study to measure neural sound feature processing in the central auditory system in relation to the individual noise sensitivity. Our results show that high noise sensitivity is associated with altered sound feature encoding and attenuated discrimination of sound noisiness in the auditory cortex. This finding makes a step towards objective measures of noise sensitivity instead of self-evaluation questionnaires and the development of strategies to prevent negative effects of noise on the susceptible population.

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A Review of Hyperacusis and Future Directions: Part I. Definitions and Manifestations

Abstract: Hyperacusis can make life difficult for many, forcing sufferers to dramatically alter their work and social habits. We believe this is an opportune time to explore approaches to better understand and treat hyperacusis.

Cited by 245 publications

References 155 publications

Noise-induced hearing loss: Neuropathic pain via Ntrk1 signaling

Noise-induced hearing loss: Neuropathic pain via Ntrk1 signaling

Characteristics of hyperacusis in the general population

A window into the brain mechanisms associated with noise sensitivity

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