A Review of Human Herpesvirus 8, the Kaposi's Sarcoma-Associated Herpesvirus, in the Pediatric Population

Dow, Dorothy; Cunningham, Coleen K.; Buchanan, Ann M.

doi:10.1093/jpids/pit051

Cited by 45 publications

(59 citation statements)

References 112 publications

(151 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The epidemiology of HHV‐8 infection and development of iatrogenic KS in the pediatric population has not yet been fully elucidated. However, data from adult patients with iatrogenic KS after solid organ transplantation indicates a cumulative risk range as low as 0.4% in North America to as high as 6% in regions of the Mediterranean and Middle East, a risk 1,000‐fold greater than non‐transplanted patients …”

Section: Childhood Ksmentioning

confidence: 99%

“…To date, there are no established consensus group therapeutic guidelines for the treatment of all four forms (epidemic, endemic, iatrogenic, and classic) of pediatric KS. Antiviral therapy (ganciclovir, valganciclovir) can be considered for prevention of (primary) HHV‐8 infection and subsequent KS development, with systemic chemotherapy (liposomal doxorubicin, liposomal daunorubicin, paclitaxel, vincristine, etoposide, and bleomycin) utilized in cases of pediatric KS with systemic disease, and intralesional chemotherapy (vinblastine, topical retinoic acid) utilized in cases of localized disease . As in adults, the control of HIV and the switch or diminution of immunosuppression is key to the control of epidemic and iatrogenic forms.…”

Section: Childhood Ksmentioning

confidence: 99%

“…[25] KS in adults and HHV-8 infection in children have been the subjects of recent reviews. [8,26] There is however no review focused on pediatric KS. We will herein review childhood KS, our current understanding of all the epidemiological forms, risk factors for KS development, as well as current treatment approaches.…”

Section: [The Copyright Line For This Article Was Updated In October mentioning

confidence: 99%

“…However, data from adult patients with iatrogenic KS after solid organ transplantation indicates a cumulative risk range as low as 0.4% in North America to as high as 6% in regions of the Mediterranean and Middle East, a risk 1,000-fold greater than nontransplanted patients. [26,51] Transmission of HHV-8. Horizontal transmission in infancy and childhood is thought to occur primarily through saliva exchange.…”

Section: Childhood Ks Epidemiologymentioning

confidence: 99%

“…KS in adults and HHV‐8 infection in children have been the subjects of recent reviews . There is however no review focused on pediatric KS.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Kaposi Sarcoma of Childhood: Inborn or Acquired Immunodeficiency to Oncogenic HHV‐8

Jackson

Dickson

Sadjadi

et al. 2015

Pediatr Blood Cancer

View full text Add to dashboard Cite

Kaposi sarcoma (KS) is an endothelial malignancy caused by human herpes virus‐8 (HHV‐8) infection. The epidemic and iatrogenic forms of childhood KS result from a profound and acquired T cell deficiency. Recent studies have shown that classic KS of childhood can result from rare single‐gene inborn errors of immunity, with mutations in WAS, IFNGR1, STIM1, and TNFRSF4. The pathogenesis of the endemic form of childhood KS has remained elusive. We review childhood KS pathogenesis and its relationship to inherited and acquired immunodeficiency to oncogenic HHV‐8.

show abstract

Section: Childhood Ksmentioning

confidence: 99%

Section: Childhood Ksmentioning

confidence: 99%