A Review of Hepatitis C in the General Population in Pakistan

Riaz, Sana; Iqbal, Atia

doi:10.4274/vhd.96729

Cited by 3 publications

(3 citation statements)

References 50 publications

(61 reference statements)

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“…20 Different lines of evidence further suggest a high ongoing HCV incidence, driven possibly by various healthcare-related procedures, such as reuse of injections, inadequate blood screening, and deficient infection control, among others. 12 Efforts to quantitatively and characterize the level and trend of the HCV epidemic in Pakistan progressively initiated in 1980. Different small projects and data compilation at district basic health units and district levels led to awareness and highlighted the upcoming danger of the epidemic.…”

Section: Discussionmentioning

confidence: 99%

“…HCV genotype 3a remains to be the most prevalent in Pakistan (61.3%). 12 conducted in different districts of the Khyber Pakhtun Khwa (KPK) province revealed anti-HCV seroprevalence in district Mardan and Mansehra, from Azad Kashmir districts Kotli and Mirpur. Studies of HCV prevalence over the last five years in Sindh Province included the districts of Karachi and Hyderabad.…”

Section: Introductionmentioning

confidence: 99%

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A preliminary screening report of HCV positive cases in district Kotli conducted in 2006 and further epidemiology of the virus in Pakistan

Ahmad

Karim

Khan

et al. 2018

IJFCM

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A preliminary screening report of HCV positive cases in district Kotli conducted in 2006 and further epidemiology of the virus in Pakistan

Ahmad

Karim

Khan

et al. 2018

IJFCM

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“…in 1989 [12] . But before this, HCV was called non-A, non-B hepatitis and belonged to the family Flaviviridae which also involves the Dengue virus [ 12 , 13 ]. However, finally, the Hepacivirus family for HCV was developed which has low sequence homology in contrast to other flaviviruses [14] .…”

Section: Molecular Evolution Of Hcvmentioning

confidence: 99%

Molecular evolution, virology and spatial distribution of HCV genotypes in Pakistan: A meta-analysis

Habib,

Anjum

et al. 2023

Infectious Medicine

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Characterizing the temporal evolution of the hepatitis C virus epidemic in Pakistan

Ayoub

Kanaani

Abu‐Raddad

2018

Journal of Viral Hepatitis

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Summary Pakistan has the second largest number of HCV infections in the world. We assessed past, present and future levels and trends of the HCV epidemic in Pakistan. An age‐structured mathematical model was developed and analysed to describe transmission dynamics over 1980‐2050. The model was fitted to a nationally representative survey and a comprehensive database of systematically gathered HCV Ab prevalence data. HCV Ab and chronic infection prevalences peaked at 5.3% and 3.9% in 2000 but were projected to decline to 4.3% and 3.2% by 2017, 3.4% and 2.6% by 2030 and 2.6% and 1.9% by 2050, respectively. The number of chronically infected individuals was estimated at 6 663 906 in 2017 and was projected to peak at 6 665 900 in 2018 and decline to 6 372 100 in 2030 and 5 131 500 in 2050. Annual number of new infections peaked at 346 740 in 1992 but was projected to decline to 198 320 in 2017, 151 090 in 2030 and 98 120 in 2050. Incidence rate per 100 000 person‐year peaked at 343 in 1988 but was projected to decline to 99 in 2017, 62 in 2030 and 36 in 2050. Prevalence and incidence varied by age, and the majority of new infections occurred in the 20‐39 age group. Prevalence and incidence of HCV in Pakistan have been slowly declining for two decades—Pakistan is enduring a large epidemic that will persist for decades if not controlled. Nearly, 10% of global infections are in Pakistan, with about 200 000 additional infections every year. Rapid and mass scale‐up of prevention and treatment programmes are critically needed.

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A Review of Hepatitis C in the General Population in Pakistan

Cited by 3 publications

References 50 publications

A preliminary screening report of HCV positive cases in district Kotli conducted in 2006 and further epidemiology of the virus in Pakistan

A preliminary screening report of HCV positive cases in district Kotli conducted in 2006 and further epidemiology of the virus in Pakistan

Molecular evolution, virology and spatial distribution of HCV genotypes in Pakistan: A meta-analysis

Characterizing the temporal evolution of the hepatitis C virus epidemic in Pakistan

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