2015
DOI: 10.1007/s00264-015-2712-z
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A review of forty five open tibial fractures covered with free flaps. Analysis of complications, microbiology and prognostic factors

Abstract: Flap cover within one week is essential to avoid infection. High-energy trauma and smoking are important predictors of complications. We suggest antibiotic prophylaxis with vancomycin and meropenem until the wound is covered in these complex injuries.

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Cited by 50 publications
(38 citation statements)
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“…A major perceived advantage is that soft tissue coverage can be delayed until the wound is no longer infected. However, the evidence suggests that delay with NPWT risks superinfection 45 and skin flora microorganisms can migrate into the wound and adhere to internal fixation material, leading to nonunion or recurrent infection. 46 Furthermore, this approach leads to multiple unnecessary operations and cost.…”
Section: Principles Of Surgical Treatmentmentioning
confidence: 99%
“…A major perceived advantage is that soft tissue coverage can be delayed until the wound is no longer infected. However, the evidence suggests that delay with NPWT risks superinfection 45 and skin flora microorganisms can migrate into the wound and adhere to internal fixation material, leading to nonunion or recurrent infection. 46 Furthermore, this approach leads to multiple unnecessary operations and cost.…”
Section: Principles Of Surgical Treatmentmentioning
confidence: 99%
“…These conditions include severe infection and local vascular problems. In the presence of infection the chance for success of plastic surgery is limited and additional surgery may be required to control infection prior to the major plastic surgery[5,14,15]. After severe trauma some limbs may be left with only one blood vessel and if it is used as a feeding artery for the graft this may threaten the limb life.…”
Section: Discussionmentioning
confidence: 99%
“…For open fractures with severe soft tissue damage, skin closure might necessitate a plastic surgical procedure using a free flap to restore the damage. In these cases, early skin closure (within a week after trauma) has a positive effect on infection rates [115]. Awaiting soft tissue coverage and preventing the wound-bed from being bacterially colonised, which might potentiate infection, demand that the would be covered.…”
Section: Surgical Debridement and Irrigationmentioning
confidence: 99%