A review of fluid flow in and around the brain, modeling, and abnormalities

Prichard, Reid; Gibson, Mirella; Joseph, Charles R; Strasser, Wayne

doi:10.1016/b978-0-12-818144-7.00015-3

Cited by 3 publications

(3 citation statements)

References 71 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There is a dimensionless number called the Péclet number (Pe), named after a physicist, that predicts which transport mechanism is the primary form. The Péclet number is the ratio of the convective flux to the diffusive flux, in which for Pe > 1, the primary transport mechanism is convection, and for Pe < 1, it is diffusion [ 55 , 56 ]. A drug’s molecular weight (MW) significantly impacts its rate and type of transport [ 57 ].…”

Section: Drug Transport In Tumor Tissuementioning

confidence: 99%

The Evolution and Recent Trends in Acoustic Targeting of Encapsulated Drugs to Solid Tumors: Strategies beyond Sonoporation

Honari

Sirsi

2023

Pharmaceutics

View full text Add to dashboard Cite

Despite recent advancements in ultrasound-mediated drug delivery and the remarkable success observed in pre-clinical studies, no delivery platform utilizing ultrasound contrast agents has yet received FDA approval. The sonoporation effect was a game-changing discovery with a promising future in clinical settings. Various clinical trials are underway to assess sonoporation’s efficacy in treating solid tumors; however, there are disagreements on its applicability to the broader population due to long-term safety issues. In this review, we first discuss how acoustic targeting of drugs gained importance in cancer pharmaceutics. Then, we discuss ultrasound-targeting strategies that have been less explored yet hold a promising future. We aim to shed light on recent innovations in ultrasound-based drug delivery including newer designs of ultrasound-sensitive particles specifically tailored for pharmaceutical usage.

show abstract

Section: Drug Transport In Tumor Tissuementioning

confidence: 99%

The Evolution and Recent Trends in Acoustic Targeting of Encapsulated Drugs to Solid Tumors: Strategies beyond Sonoporation

Honari

Sirsi

2023

Pharmaceutics

View full text Add to dashboard Cite

show abstract

“…The k term in Equation ( 12) is the thermal conductivity of the working fluid. Equation ( 13) elucidates the equation to procure the Reynolds number and is defined as the ratio of inertial forces to viscous forces within a fluid [58].…”

Section: Data Reductionmentioning

confidence: 99%

Thermohydraulic and Irreversibility Analyses of Swirl Flows Utilizing Distorted Radial Fins: Entropy Generation and Entransy Dissipation Evaluation

Ho,

Tan,

Hung

et al. 2023

International Journal of Energy Research

View full text Add to dashboard Cite

The current investigation analyses the convective heat transfer performance, entropy generation, and entransy evaluation of swirl flows generated by distorted radial fins (DRF). As swirl flows and various vortical structures induce large temperature gradients, second law and entransy analyses are necessary to thoroughly evaluate their true thermodynamic influence on heat transfer enhancement. The results indicated that due to the influence of swirl flows and vortices, all angles of the DRF were capable of inducing intense fluid mixing, thinner thermal boundary layers, and turbulent eddies. It was found that overaggressive swirl flows may hinder local heat transfer performances, by enclosing low-velocity heated fluids within the thermal boundary layers. However, as these overaggressive swirl flows and strong vortices propagate downstream, beneficial fluid mixing was eventuated, favouring heat transport over large regions. In terms of thermal performances, the maximum heat transfer enhancement was exhibited by the α=45° DRF, improving the Nusselt numbers up to 59.3%. Accordingly, the highest performance evaluation criterion (PEC) of 1.269 was obtained by the α=45° DRF at the Reynolds number 2389, attributed to the centrifugal effects of the swirl flows. Optimal entropy generation numbers were also exhibited by the α=45° DRF at the highest studied Reynolds number, reducing total entropy generation by 36.81%. Lower entransy thermal resistances were also accredited to greater DRF angles due to the intense swirl effects. In essence, the study concludes that the effects of swirl flows and vortices significantly enhance heat transfer, whilst reducing both entropy generation and entransy dissipation rates, leading to optimal thermal performances.

show abstract

“…Dividing the convection rate of a physical quantity by its rate of diffusion, results in the derivation of the Peclet dimensionless number, 𝑃𝑒, which basically is the product of the Reynolds, Re, and Schmidt, Sc, dimensionless numbers (equation (2.12)) [72,73].…”

Section: Back-mixing and Deviation Of Reactors From The Ideal Conditionsmentioning

confidence: 99%

Combined computational-experimental study on plasma and plasma catalysis for N2 fixation

Ahmadi Eshtehardi

View full text Add to dashboard Cite

A review of fluid flow in and around the brain, modeling, and abnormalities

Cited by 3 publications

References 71 publications

The Evolution and Recent Trends in Acoustic Targeting of Encapsulated Drugs to Solid Tumors: Strategies beyond Sonoporation

The Evolution and Recent Trends in Acoustic Targeting of Encapsulated Drugs to Solid Tumors: Strategies beyond Sonoporation

Thermohydraulic and Irreversibility Analyses of Swirl Flows Utilizing Distorted Radial Fins: Entropy Generation and Entransy Dissipation Evaluation

Combined computational-experimental study on plasma and plasma catalysis for N2 fixation

Contact Info

Product

Resources

About