A review of famciclovir in the management of genital herpes

Faro, Sebastian

doi:10.1002/(sici)1098-0997(1998)6:1<38::aid-idog8>3.0.co;2-3

Cited by 5 publications

(5 citation statements)

References 27 publications

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“…•Famciclovir , 250 mg t.d.s. for 7–10 days, is the prodrug of penciclovir, a new agent which also has a higher bioavailability than acyclovir and has been shown to be effective in suppressing recurrent genital herpes (18).…”

Section: Genital Herpesmentioning

confidence: 99%

Viral sexually transmitted infections: current management strategies. REVIEW ARTICLE

Tariq

Ross

1999

J Clin Pharm Ther

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SUMMARYmeasures, treatment can take several weeks and frequent recurrences may cause frustration for both cliniViral sexually transmitted infections are a major cian and patient. The patient may also be concerned health problem associated with considerable morabout the risks of transmission, coping with sexual bidity. This article reviews the current strategies used relationships and the need for regular cytological rein the management of infections such as genital view because of the established linkage of human warts, genital herpes and molluscum contagiosum.papilloma virus to cervical cancer (3). In these cirPros and cons of different treatment regimens have cumstances, understanding the psycho-social aspects been discussed with an emphasis on a selective of these diseases is a vital part of the management of approach to therapy. The importance of education, patients, which should include providing both effectcounselling and follow-up is highlighted and issues ive treatment and appropriate counselling. relating to the associated psychosexual morbidity have been addressed. Treatment of these infections in pregnancy and HIV has also been described.

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Section: Genital Herpesmentioning

confidence: 99%

Viral sexually transmitted infections: current management strategies. REVIEW ARTICLE

Tariq

Ross

1999

J Clin Pharm Ther

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“…272 Famciclovir is an alternative treatment option for genital herpes. 273,274 As substantiated by research findings, zinc has demonstrated the capacity to impede the viral life cycle of HSV. 275 Furthermore, an investigator study has highlighted the potential benefits of synergising eucalyptol and acyclovir in addressing resistant HSV infections.…”

Section: Current Antiviral Therapies For Hsv Infectionmentioning

confidence: 97%

“…Efforts to address these challenges include developing innovative therapies targeting acyclovir‐resistant herpes simplex keratitis 272 . Famciclovir is an alternative treatment option for genital herpes 273,274 . As substantiated by research findings, zinc has demonstrated the capacity to impede the viral life cycle of HSV 275 .…”

Section: Therapeutic Approaches and Future Directionsmentioning

confidence: 99%

Immunopathology of herpes simplex virus‐associated neuroinflammation: Unveiling the mysteries

Hussain,

Gupta,

Samuel

et al. 2023

Reviews in Medical Virology

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The immunopathology of herpes simplex virus (HSV)‐associated neuroinflammation is a captivating and intricate field of study within the scientific community. HSV, renowned for its latent infection capability, gives rise to a spectrum of neurological expressions, ranging from mild symptoms to severe encephalitis. The enigmatic interplay between the virus and the host's immune responses profoundly shapes the outcome of these infections. This review delves into the multifaceted immune reactions triggered by HSV within neural tissues, intricately encompassing the interplay between innate and adaptive immunity. Furthermore, this analysis delves into the delicate equilibrium between immune defence and the potential for immunopathology‐induced neural damage. It meticulously dissects the roles of diverse immune cells, cytokines, and chemokines, unravelling the intricacies of neuroinflammation modulation and its subsequent effects. By exploring HSV's immune manipulation and exploitation mechanisms, this review endeavours to unveil the enigmas surrounding the immunopathology of HSV‐associated neuroinflammation. This comprehensive understanding enhances our grasp of viral pathogenesis and holds promise for pioneering therapeutic strategies designed to mitigate the neurological ramifications of HSV infections.

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“…Its mechanism of action is through penciclovir; penciclovir triphosphate inhibits herpes DNA synthesis by acting as a substrate for viral DNA polymerase. The major clinical indications for famciclovir use are treatment of herpes zoster, recurrent genital herpes, 52 and recurrent herpes labialis. 53 Famciclovir can also be used as suppression therapy to reduce the risk of recurrent genital herpes as well as oral treatment of uncomplicated varicella in HIV-infected patients.…”

Section: Antiherpes Drugsmentioning

confidence: 99%

Antiviral Drugs for Viruses Other Than Human Immunodeficiency Virus

Razonable

2011

Mayo Clinic Proceedings

215

133

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Most viral diseases, with the exception of those caused by human immunodeficiency virus, are self-limited illnesses that do not require specific antiviral therapy. The currently available antiviral drugs target 3 main groups of viruses: herpes, hepatitis, and influenza viruses. With the exception of the antisense molecule fomivirsen, all antiherpes drugs inhibit viral replication by serving as competitive substrates for viral DNA polymerase. Drugs for the treatment of influenza inhibit the ion channel M(2) protein or the enzyme neuraminidase. Combination therapy with Interferon-α and ribavirin remains the backbone treatment for chronic hepatitis C; the addition of serine protease inhibitors improves the treatment outcome of patients infected with hepatitis C virus genotype 1. Chronic hepatitis B can be treated with interferon or a combination of nucleos(t)ide analogues. Notably, almost all the nucleos(t) ide analogues for the treatment of chronic hepatitis B possess anti-human immunodeficiency virus properties, and they inhibit replication of hepatitis B virus by serving as competitive substrates for its DNA polymerase. Some antiviral drugs possess multiple potential clinical applications, such as ribavirin for the treatment of chronic hepatitis C and respiratory syncytial virus and cidofovir for the treatment of cytomegalovirus and other DNA viruses. Drug resistance is an emerging threat to the clinical utility of antiviral drugs. The major mechanisms for drug resistance are mutations in the viral DNA polymerase gene or in genes that encode for the viral kinases required for the activation of certain drugs such as acyclovir and ganciclovir. Widespread antiviral resistance has limited the clinical utility of M(2) inhibitors for the prevention and treatment of influenza infections. This article provides an overview of clinically available antiviral drugs for the primary care physician, with a special focus on pharmacology, clinical uses, and adverse effects.

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A review of famciclovir in the management of genital herpes

Cited by 5 publications

References 27 publications

Viral sexually transmitted infections: current management strategies. REVIEW ARTICLE

Viral sexually transmitted infections: current management strategies. REVIEW ARTICLE

Immunopathology of herpes simplex virus‐associated neuroinflammation: Unveiling the mysteries

Antiviral Drugs for Viruses Other Than Human Immunodeficiency Virus

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