A review of epidemiological evidence for general anesthesia as a risk factor for Alzheimer's disease

Seitz, Dallas; Reimer, Cara; Siddiqui, Naveed

doi:10.1016/j.pnpbp.2012.06.022

Cited by 36 publications

(23 citation statements)

References 40 publications

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“…Hyperphosphorylation of tau also occurs during early developmental phases when it enables axonal growth cones to achieve maximal flexibility for guidance of axons to their target regions and for synapse formation. Thus, an occasional and limited degree of hyperphosphorylation at appropriate sites solely on the part of monomeric tau is not an index of a disease state (Arendt 2004;Run et al 2009;Seitz et al 2012;Whittington et al 2013).…”

Section: Chapter 4 Microtubules and The Protein Taumentioning

confidence: 99%

Neuroanatomy and Pathology of Sporadic Alzheimer's Disease

Braak

Tredici

2015

Advances in Anatomy, Embryology and Cell Biology

184

266

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Reviews and critical articles covering the entire field of normal anatomy (cytology, histology, cyto-and histochemistry, electron microscopy, macroscopy, experimental morphology and embryology and comparative anatomy) are published in Advances in Anatomy, Embryology and Cell Biology. Papers dealing with anthropology and clinical morphology that aim to encourage cooperation between anatomy andrelated disciplines will also be accepted. Papers are normally commissioned. Original papers and communications may be submitted and will be considered for publication provided they meet the requirements of a review article and thus fit into the scope of "Advances". English language is preferred. It is a fundamental condition that submitted manuscripts have not been and will not simultaneously be submitted or published elsewhere. With the acceptance of a manuscript for publication, the publisher acquires full and exclusive copyright for all languages and countries.

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Section: Chapter 4 Microtubules and The Protein Taumentioning

confidence: 99%

Neuroanatomy and Pathology of Sporadic Alzheimer's Disease

Braak

Tredici

2015

Advances in Anatomy, Embryology and Cell Biology

184

266

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“…While some population-based studies show an age-of-exposure and dose-response relationship of general anesthesia and dementia risk (Chen et al 2014), others have not shown this association (Sprung et al 2013). Meta-analysis results consolidating data from 15 case-control studies indicated no significant association between prior exposure to general anesthesia and incident AD dementia (Seitz, Reimer, & Siddiqui 2013). Avidan and Evers (2011) also determined there is minimal clinical evidence linking surgery or anesthesia to developing dementia.…”

Section: Surgeries and Anesthesiamentioning

confidence: 99%

Factors Influencing Clinical Correlates of Chronic Traumatic Encephalopathy (CTE): a Review

et al. 2016

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Chronic traumatic encephalopathy (CTE) is a neuropathologically defined disease reportedly linked to a history of repetitive brain trauma. As such, retired collision sport athletes are likely at heightened risk for developing CTE. Researchers have described distinct pathological features of CTE as well a wide range of clinical symptom presentations, recently termed traumatic encephalopathy syndrome (TES). These clinical symptoms are highly variable, non-specific to individuals described as having CTE pathology in case reports, and are often associated with many other factors. This review describes the cognitive, emotional, and behavioral changes associated with 1) developmental and demographic factors, 2) neurodevelopmental disorders, 3) normal aging, 4) adjusting to retirement, 5) drug and alcohol abuse, 6) surgeries and anesthesia, and 7) sleep difficulties, as well as the relationship between these factors and risk for developing dementia-related neurodegenerative disease. We discuss why some professional athletes may be particularly susceptible to many of these effects and the importance of choosing appropriate controls groups when designing research protocols. We conclude that these factors should be considered as modifiers predominantly of the clinical outcomes associated with repetitive brain trauma within a broader biopsychosocial framework when interpreting and attributing symptom development, though also note potential effects on neuropathological outcomes. Importantly, this could have significant treatment implications for improving quality of life.

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“…Some inhalational agents used in GA have been associated with Alzheimer's disease pathology, including greater accumulation of beta‐amyloid and hyperphosphorylated tau proteins . Evidence of the promotion of Alzheimer's disease pathology associated with GA from observational studies of humans has not found consistent associations between GA and dementia . The few randomized controlled studies in this area have not demonstrated a consistently greater risk of dementia with GA .…”

Section: Discussionmentioning

confidence: 99%