A Review of Enrofloxacin for Veterinary Use

Trouchon, Tessa; Lefebvre, Sébastien

doi:10.4236/ojvm.2016.62006

Cited by 158 publications

(103 citation statements)

References 115 publications

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“…Enrofloksasin dapat diekskresikan melalui feses, urin dan lainnya. Proses penurunan konsentrasi enrofloksasin pada tubuh ayam bagian daging paha lebih cepat dibandingkan dengan bagian dada, karena aktivitas otot paha lebih tinggi dibandingkan dengan daging dada (Widiastuti 2008;Trouchon & Lefebvre 2016). Waktu henti obat (withdrawal time) antibiotik dengan dosis 2,5 mg/kg berat badan secara intramuscular adalah pada hari ke-6.…”

Section: Antibiotik Enrofloksasin Dan Mekanisme Kerjanyaunclassified

“…Antibiotik yang dapat diberikan pada hewan salah satunya adalah antibiotik golongan fluorokuinolon. Penjualan fluorokuinolon mencapai 3,6 ton per tahun yang digunakan untuk pengobatan infeksi pada hewan di negara Perancis (Trouchon & Lefebvre 2016). Fluorokuinolon dapat digunakan untuk penanganan penyakit pada unggas, sapi, kambing, domba, babi, kuda dan ikan.…”

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“…Antibiotik enrofloksasin merupakan antibiotik berspektrum luas, sehingga efektif untuk pengobatan penyakit yang disebabkan oleh infeksi bakteri Gram positif dan Gram negatif. Namun, antibiotik enrofloksasin dapat menyebabkan gangguan syaraf, kardiotoksik, kebutaan, kematian embrionik serta toksisitas pada lingkungan (ekotoksisitas) (Trouchon & Lefebvre 2016;Kang et al 2019;Wei et al 2018). Penggunaan antibiotik enrofloksasin pada hewan juga dapat menyebabkan residu dan resistensi mikroba, sehingga penggunaan antibiotik enrofloksasin harus diawasi dan dievaluasi demi keamanan pangan dan kesehatan manusia (Mansouri-najand et al 2012;Moharana et al 2015).…”

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The Use of Enrofloxacin Antibiotic as a Veterinary Drug and Its Residual Hazards on Public Health

Widiyanti¹,

Sudarwanto²,

Sudarnika³

et al. 2019

WARTAZOA

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The livestock sector can improve the community's economy and has a role in fulfilling food needs, especially animal protein. One of the problems in the livestock sector is the presence of infectious diseases that consequently need treatment using veterinary drugs. This paper describes the use of enrofloxacin antibiotics as veterinary drug and their residual hazards on public health. Enrofloxacin is an antibiotic from the family of fluoroquinolones (second generation of quinolone). Enrofloxacin is a broad-spectrum antibiotic that is effective to kill Gram positive and negative bacteria, so it was used for the treatment of various diseases in animals. Pharmacokinetically, enrofloxacin will be metabolized into ciprofloxacin and other metabolites. The improper use of enrofloxacin antibiotics caused residues in food products of animal origin, microbial resistance and toxicity, therefore the use of enrofloxacin needs to be monitored and evaluated for the sake of animal health and society.

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Section: Antibiotik Enrofloksasin Dan Mekanisme Kerjanyaunclassified

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The Use of Enrofloxacin Antibiotic as a Veterinary Drug and Its Residual Hazards on Public Health

Widiyanti¹,

Sudarwanto²,

Sudarnika³

et al. 2019

WARTAZOA

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“…1 It is used in veterinary medicine for the treatment of respiratory, digestive, urinary, mammary, and dermal infections in poultry, cattle, rodents, and domestic carnivores that are caused by many gram-positive and gram-negative bacteria. 1 It is used in veterinary medicine for the treatment of respiratory, digestive, urinary, mammary, and dermal infections in poultry, cattle, rodents, and domestic carnivores that are caused by many gram-positive and gram-negative bacteria.…”

Section: Introductionmentioning

confidence: 99%

“…Enrofloxacin (ENR) is a third generation fluoroquinolone that belongs to a subfamily of quinolone. 1 It is used in veterinary medicine for the treatment of respiratory, digestive, urinary, mammary, and dermal infections in poultry, cattle, rodents, and domestic carnivores that are caused by many gram-positive and gram-negative bacteria. [2][3][4][5][6] As a result, ENR is widely used as an antibiotic in livestock farming and aquaculture; however, there are concerns surrounding its use because of its large antimicrobial spectrum.…”

Section: Introductionmentioning

confidence: 99%

Preparation of cadmium sulfide nanoparticles and their application for improving the properties of the electrochemical sensor for the determination of enrofloxacin in real samples

Liu

Zhang

2019

Chirality

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An advanced electrochemical sensor for the detection of enrofloxacin (ENR) based on the use of a modified electrode containing cadmium sulfide (CdS) nanoparticles (NPs) is reported. The CdS NPs were synthesized and characterized and then coated onto the electrode to fabricate a modified electrode that exhibited a lower limit of detection of 9.5 × 10 −8 mol·L −1 . This detection limit compares with a traditional electrode that exhibited a concentration detection range of 1.0 × 10 −2 to 1.0 × 10 −7 mol·L −1 . This modified electrode demonstrated good selectivity, reproducibility, response time (<40 s), lifetime (up to 12 wk), and pH range (3.3-7.2) for the determination of ENR in real samples (eg, pig urine).

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Two novel Cu (II) levofloxacin complexes with different bioactive nitrogen‐based ligands; single‐crystal X‐ray and various biological activities determinations

Mubarak

Ali

Metani

2021

Applied Organom Chemis

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Two new copper (II) complexes with the third generation quinolone antibacterial agent levofloxacin, 2‐aminopyridine and 2,2′‐bipyridine nitrogen‐based ligands with the following molecular structures [Cu (levo)2(2‐ampy)].6.25H2O (1) and [Cu (levo)(H2O)(2,2‐bipy)](NO3).2.5H2O (2) were synthesized. The complexes were characterized by spectroscopic methods and others. The crystal structure of complex 1 revealed that the Cu (II) cation is coordinated to two bidentate chelating levofloxacinato ligands, and one monodentate 2‐ampy ligand in the axial position forming a slightly distorted square pyramidal geometry. The mononuclear cationic complex 2 was determined in the triclinic crystal system and the chiral space group P1 with four molecules per unit cell in which the Cu (II) cation is coordinated to one bidentate chelating levofloxacinato ligand, one bidentate 2,2‐bipy, and one water molecule in a distorted square pyramidal geometry. In vitro antibacterial activities for the complexes and their parent ligands against four gram‐negative bacteria (Proteus mirabilis, Escherichia coli, Pseudomonas aeruginosa, and Klebsiella pneumonia) and four gram‐positive bacteria (Staphylococcus aureus, Staphylococcus epidermidis, Bacillus subtilis, and Enterococcus faecalis) using the agar diffusion method have been determined with inhibition zone diameter (IZD) values between 29 and 46 mm. In addition, the minimum inhibition concentration (MIC) and the minimum bactericidal concentration (MBC) have been investigated. The MIC results of complexes 1 and 2 showed significant antibacterial activities against the P. mirabilis and B. subtilis than levofloxacin.

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A Review of Enrofloxacin for Veterinary Use

Cited by 158 publications

References 115 publications

The Use of Enrofloxacin Antibiotic as a Veterinary Drug and Its Residual Hazards on Public Health

The Use of Enrofloxacin Antibiotic as a Veterinary Drug and Its Residual Hazards on Public Health

Preparation of cadmium sulfide nanoparticles and their application for improving the properties of the electrochemical sensor for the determination of enrofloxacin in real samples

Two novel Cu (II) levofloxacin complexes with different bioactive nitrogen‐based ligands; single‐crystal X‐ray and various biological activities determinations

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