A Review of Endophytic Microbiota of Medicinal Plants and Their Antimicrobial Properties

Sarah, Robeena; Idrees, Nida; Tabassum, Baby

doi:10.1002/9781119830795.ch1

Cited by 4 publications

(3 citation statements)

References 47 publications

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“…The presence of endophytic microorganisms within host plants can result in the manifestation of extraordinary features such as stress tolerance and the production of compounds that can combat invading infections (14) . Particularly for the production of valuable antibacterial compounds, medicinal plants can be excellent sources of unique endophytic microorganisms (15) . Avicennia marina is one such exceptional plant with outstanding therapeutic capabilities that was investigated to detect the presence of an endophytic fungus.…”

Section: Identification Of Fungimentioning

confidence: 99%

Statistical Optimization for the Production of Antimicrobial Compounds Produced by Mangrove Endophytic Aspergillus sp.

Trivedi¹,

Thumar²

2023

IJST

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Objectives:The purpose of this study was to investigate the antibacterial properties of an endophytic fungus, Aspergillus sp., isolated from the roots of the Avicennia marina belonging to an unexplored location in Kutch, Gujarat, India. The study aimed to optimize various factors to enhance the production of antimicrobial compounds. Methodology: Antimicrobial activity was performed using the agar-well diffusion method, and the results were compared with the standard antibiotic streptomycin as a positive control and DMSO as a negative control. The classical one-factor-at-a-time (OFT) approach was used to optimize various factors such as temperature, pH, culture media, carbon and nitrogen sources, and solvents to enhance antimicrobial production. Response Surface Methodology (RSM) was used to statistically optimize the production of antimicrobial compounds. Findings: The investigation revealed that the endophyte exhibited remarkable inhibitory action against sensitive strains of Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa, Bacillus cereus, and Staphylococcus aureus. The most suitable conditions for the production of antimicrobials were; an inoculum size of 1*10 5 in potato dextrose medium at a temperature of 25 • C and pH 6, with an incubation period of 12 days. Starch and ammonium chloride acted as the best carbon and nitrogen sources, respectively. The use of RSM resulted in a 1.46-fold increase in the antimicrobial activity against Pseudomonas sp., with an increase in the zone of inhibition from 18.36mm to 26.8mm. Novelty: The study highlights the unique antimicrobial potential of an unexplored endophyte derived from Avicennia marina roots in Kutch, Gujarat, India. RSM played a crucial role in detecting optimum conditions for the production of antimicrobial compounds, resulting in a significant increase in activity. Its application emphasizes the importance of advanced statistical techniques in improving our understanding of complex biological systems.

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Section: Identification Of Fungimentioning

confidence: 99%

Statistical Optimization for the Production of Antimicrobial Compounds Produced by Mangrove Endophytic Aspergillus sp.

Trivedi¹,

Thumar²

2023

IJST

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“…Medicinal and aromatic antimicrobial agents that may be effective against resistant strains are under investigation [5]. The medicinal properties of plants have been passed down from one society to the next for centuries [6]. Antimicrobial agents found in plants have an enormous therapeutic potential [7].…”

Section: Introductionmentioning

confidence: 99%

An Innovative Approach to Various Industrial Applications: The Fingered Citron

Tasbasi,

Asan-Ozusaglam

2024

Hung. J. Ind. Chem.

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The fingered citron (Citrus medica L. var. sarcodactylis), which originates from India, has spread to different parts of the world over time. In opposition to the increasing resistance to traditional antimicrobial agents, the application of alternative treatments developed using herbs has recently gained interest. The aim of this study is to investigate alternative applications of the fingered citron in the cosmetics and pharmaceutical industries. For this purpose, the antimicrobial activity of fingered citron leaf water extract (FCLWE) against test microorganisms was evaluated using a disk diffusion assay. Minimum inhibitory concentration (MIC) and minimum cidal concentrations (bactericidal - MBC or fungicidal - MFC) of the extract were also determined. For FCLWE, among the pathogenic test microorganisms, Listeria monocytogenes strain ATCC 7644 and Staphylococcus aureus strain ATCC 25923 showed the smallest and the largest inhibition zone diameters, with values of 7.06 and 11.57 mm, respectively. MIC and MBC or MFC values of FCLWE varied from 10 to 40 µg/µl. In addition, the sun protection factors (SPF) of FCLWE and a mixture of FCLWE and commercial sun creams at different concentrations were determined. The SPF value of FCLWE was found to be 25. The mixture of FCLWE and commercial sun cream at an amount of 10 ml yielded an SPF value of 12.26. Next, the biological activity of the cream formulation obtained with commercial cream, FCLWE and Limosilactobacillus fermentum MA-7 (cream-leaf water extract-probiotic - CWP) was investigated against test microorganisms using the well diffusion method. CWP exhibited inhibitory activity against L. monocytogenes ATCC 7644 (2.56 mm), Candida glabrata RSKK 04019 (2.81 mm), C. albicans ATCC 10231 (4.54 mm) and S. aureus ATCC 25923 (5.00 mm). It was observed that the cream formulation of CWP increased the diameters of the inhibition zone by creating a synergistic effect against all pathogenic test microorganisms. FCLWE may potentially be used as an alternative natural additive to chemical preservatives in the cosmetics and pharmaceutical industries.

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“…Various endophytic microflora has been isolated from various parts of neem plants. [9][10][11][12] These microbes have also been characterized for their secondary metabolite-production capabilities.…”

Section: Introductionmentioning

confidence: 99%

Deciphering Azadirachta indica (Neem) Gum Microbiome using Metagenomic Approaches

Saxena¹,

Singh²,

Chakdar³

et al. 2023

J. Pure Appl. Microbiol.

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Indian lilac or neem (Azadirachta indica) is found in tropical and subtropical regions of the Indian subcontinent. Each part of the tree is a source of various phytochemicals. Neem gum is an exudate from mature parts of the plant stem. Biochemically, it has an acidic pH range (5–6) and is composed of monosaccharides, saponins, phenols, and tannins. This study aimed to elucidate the diversity of neem gum-associated microflora through high throughput metagenomics approach using 16S rRNA variable region sequencing. The bacterial community of neem gum was dominated by Firmicutes (~82%), Proteobacteria (~18%), and Actinobacteria (~0.02%). Among the genera, Lactococcus was found to be the most dominant bacterium. The predominance of Lactococcus in neem gum is probably due to its acidic nature, which provides a suitable microenvironment for its proliferation. In addition, Lactococcus and beneficial microorganisms such as Pseudomonas, Burkholderia, Pantoea, Klebsiella, and Methylobacterium were also present in the gum. This study highlights the fact that neem gum can be exploited as a unique source of microorganisms for biotechnological and agricultural applications.

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A Review of Endophytic Microbiota of Medicinal Plants and Their Antimicrobial Properties

Cited by 4 publications

References 47 publications

Statistical Optimization for the Production of Antimicrobial Compounds Produced by Mangrove Endophytic Aspergillus sp.

Statistical Optimization for the Production of Antimicrobial Compounds Produced by Mangrove Endophytic Aspergillus sp.

An Innovative Approach to Various Industrial Applications: The Fingered Citron

Deciphering Azadirachta indica (Neem) Gum Microbiome using Metagenomic Approaches

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