A review of enantioselective dual transition metal/photoredox catalysis

Recent developments in enantioselective photocatalysis

“…Transition metal complexes with chiral ligands have also been used extensively in enantioselective catalysis. A recent review on enantioselective metallaphotoredox catalysis summarises the combination of these two bodies of work well [15]. This section is further categorised into subsections by the transition metal used.…”

“…This review aims to cover the seminal work within enantioselective photocatalysis but with a focus on the most recent devel-opments. There have been a number of reviews on or closely related to this topic, so this review will not contain an exhaustive list of all enantioselective photocatalytic reactions; however, this review does aim to cover the different strategies that have been developed [5][6][7][8][9][10][11][12][13][14][15][16]. There is a subset of reactions that achieve asymmetry via a stepwise photochemical process followed by a separate enantioselective catalysis step that will not be covered in this review [17][18][19].…”

Asymmetric Three-Component Olefin Dicarbofunctionalization Enabled by Photoredox and Copper Dual Catalysis

“…In recent years, visible-light photoredox catalysis has emerged as a powerful tool for organic chemists to develop many elusive radical-mediated chemical transformations with high levels of functional group tolerance [33][34][35][36] . This activation mode also provides a promising approach for development of radical multicomponent reactions (in some cases with excellent stereoselectivity) [37][38][39][40][41][42] . For example, the Studer group recently developed an asymmetric three-component cascade reaction of quinolines or pyridines with enamides using α-bromo carbonyl compounds as radical precursors under photoredox and phosphoric acid dual catalysis 43 .…”

Dual Ni/photoredox-catalyzed asymmetric cross-coupling to access chiral benzylic boronic esters

“…Such cooperative regime, especially with nickel, provides a novel catalytic mode in asymmetric crosscouplings under exceptionally mild conditions and avoids the use of air-sensitive organometallic reagents or stoichiometric metal reductants (Fig. 1a) 7,8 . Currently, dual Ni/photoredoxcatalyzed asymmetric couplings typically involve redox-neutral methods, such as Suzuki-Miyaura reactions, but few reductive cross-couplings have been reported [9][10][11][12][13][14][15] .…”