Abstract:The mechanism of electrocardiography (ECG) changes in patients with scrub typhus is still not clear. Orientia tsutsugamushi causes vasculitis in scrub typhus patients, which result in non-specific damage to the heart. However, serious damage to myofibril of the heart is not accompanied. Thus, chronic cardiac sequelae are rare. In addition to myocarditis, a variety of cardiac complications such as myocardial infarction, pericarditis have been reported. Additional research is needed to clarify the main mechanism… Show more
“…Moreover, as the mean age of patients with scrub typhus in the study from Thailand was 39 years [10], influences related to age or underlying disease would likely explain the observed differences in the frequency of ECG abnormalities. 12 Atrial fibrillation was the most commonly observed type of arrhythmia observed in patients with scrub typhus. In Korea, the reported prevalence rates of Afib were 0.7% in people aged ³ 40 years, 2.1% in people aged ³ 65 years, and 4.0% in people aged ³ 80 years.…”
This study compared the frequency of abnormal electrocardiogram (ECG) types between scrub typhus patient group and age-and gender-matched health checkup group and their associations with disease severity in scrub typhus patient. Demographic characteristics and ECG and laboratory findings of patients with scrub typhus admitted to Chosun University Hospital, and normal subjects visiting the hospital for health checkup from January 2008 to December 2012 were retrospectively studied. Electrocardiogram abnormalities at admission were observed in 72 of 165 (43.6%) scrub typhus confirmed patients. The following ECG abnormalities were observed: arrhythmic group (31 cases, 18.8%), ischemic change group (25 cases, 15.1%), prolonged QT group (32 cases, 19.4%).Compared with the age and gendermatched health checkup group, ECG abnormalities were more commonly observed in scrub typhus patient group (13.9% versus 43.6%, P < 0.001). In addition, when compared with the normal ECG group, scrub typhus in the abnormal ECG group showed greater disease severity and this phenomenon was particularly prominent in the prolonged QT group. Based on our study prolonged QT observed in approximately 20% of patients with scrub typhus, clinicians should pay additional attention to drugs that affect QT interval.
“…Moreover, as the mean age of patients with scrub typhus in the study from Thailand was 39 years [10], influences related to age or underlying disease would likely explain the observed differences in the frequency of ECG abnormalities. 12 Atrial fibrillation was the most commonly observed type of arrhythmia observed in patients with scrub typhus. In Korea, the reported prevalence rates of Afib were 0.7% in people aged ³ 40 years, 2.1% in people aged ³ 65 years, and 4.0% in people aged ³ 80 years.…”
This study compared the frequency of abnormal electrocardiogram (ECG) types between scrub typhus patient group and age-and gender-matched health checkup group and their associations with disease severity in scrub typhus patient. Demographic characteristics and ECG and laboratory findings of patients with scrub typhus admitted to Chosun University Hospital, and normal subjects visiting the hospital for health checkup from January 2008 to December 2012 were retrospectively studied. Electrocardiogram abnormalities at admission were observed in 72 of 165 (43.6%) scrub typhus confirmed patients. The following ECG abnormalities were observed: arrhythmic group (31 cases, 18.8%), ischemic change group (25 cases, 15.1%), prolonged QT group (32 cases, 19.4%).Compared with the age and gendermatched health checkup group, ECG abnormalities were more commonly observed in scrub typhus patient group (13.9% versus 43.6%, P < 0.001). In addition, when compared with the normal ECG group, scrub typhus in the abnormal ECG group showed greater disease severity and this phenomenon was particularly prominent in the prolonged QT group. Based on our study prolonged QT observed in approximately 20% of patients with scrub typhus, clinicians should pay additional attention to drugs that affect QT interval.
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