A review of disparities in peripheral artery disease and diabetes–related amputations during the COVID-19 pandemic

Pride, Laura; Kabeil, Mahmood; Alabi, Olamide; Minc, Samantha D.; Fakorede, Foluso; Ochoa, Lyssa N.; Wright, Ann; Wohlauer, Max V.

doi:10.1053/j.semvascsurg.2022.12.002

Cited by 2 publications

(1 citation statement)

References 47 publications

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“…A recent systematic review found that only 2 of the 14 included publications on amputation rates in patients with lower extremity PAD, and 0 of the 11 included publications on diabetes-related amputations during the COVID-19 pandemic include race or ethnicity in their analyses. 120 These data, along with others we found, are presented below. However, the paucity of data once again highlights the need to more rigorously study the diagnosis and management of and outcomes associated with PAD in diverse populations.…”

Section: Pad the Covid-19 Pandemic And Disparitiessupporting

confidence: 62%

Sex and Racial Disparities in Peripheral Artery Disease

Divakaran,

Krawisz,

Secemsky

et al. 2023

ATVB

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Several studies have shown that women and racial and ethnic minority patients are at increased risk of developing lower extremity peripheral artery disease and suffering adverse outcomes from it, but a knowledge gap remains regarding the underlying causes of these increased risks. Both groups are more likely to be underdiagnosed, have poorly managed contributory comorbidities, and incur disparities in treatment and management postdiagnosis. Opportunities for improvement in the care of women and racial and ethnic minorities with peripheral artery disease include increased rates of screening, higher rates of clinical suspicion (particularly in the absence of typical symptoms of intermittent claudication), and more aggressive risk factor management before and after the diagnosis of peripheral artery disease.

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Section: Pad the Covid-19 Pandemic And Disparitiessupporting

confidence: 62%

Sex and Racial Disparities in Peripheral Artery Disease

Divakaran,

Krawisz,

Secemsky

et al. 2023

ATVB

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Increase in antibiotic resistance in diabetic foot infections among peruvian patients: a single-center cross-sectional study

Moya-Salazar,

Chamana,

Porras-Rivera

et al. 2023

Front. Endocrinol.

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BackgroundDiabetic foot is one of the most significant complications in individuals with diabetes and is closely associated with lower limb amputation. The antibiotic susceptibility patterns of these bacterial isolates play a critical role in guiding effective treatment strategies We aimed to determine the most common bacterial agents causing diabetic foot infections in a tertiary-care hospital in Peru.MethodsClinical and microbiological data were collected from 181 patients diagnosed with diabetic foot infections and positive microbiological culture results. All the samples were analyzed with the Vitek 2 compact system and the cut-off points were defined with the CLSI M100 guide. The data were segregated based on mono-microbial or poly-microbial cultures, bacterial types, and antibiotic susceptibility profiles.ResultsA total of 32 bacterial species were identified, predominantly Gram-negative (63%). The most frequent bacterial agents isolated were Staphylococcus aureus (19.9%), Escherichia coli (12.2%), Pseudomonas aeruginosa (8.3%), and Proteus vulgaris (6.6%). These bacteria commonly exhibited resistance to Ampicillin, Ciprofloxacin, Levofloxacin, Trimethoprim-sulfamethoxazole, and Cefuroxime. E. coli showed the highest antibiotic resistance (19 antibiotics), while Gentamicin, Tobramycin, and Levofloxacin demonstrated the highest sensitivity against the most prevalent bacteria. Gram-negative bacteria also exhibited notable antibiotic-susceptibility to Meropenem, Piperacillin/tazobactam, and Amikacin. Regarding the presence of Extended-Spectrum Beta-Lactamase, 54 isolates tested positive, with 35 (64.8%) and 14 (42.4%) of these being S. aureus and E. coli.ConclusionsBacterial agents causing diabetic foot infections pose a constant concern, particularly due to the increasing antibiotic resistance observed. This difficulty in treating the condition contributes to a higher risk of amputation and mortality. Further research on bacterial susceptibility is necessary to determine appropriate dosages for pharmacological treatment and to prevent the overuse of antibiotics.

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A review of disparities in peripheral artery disease and diabetes–related amputations during the COVID-19 pandemic

Cited by 2 publications

References 47 publications

Sex and Racial Disparities in Peripheral Artery Disease

Sex and Racial Disparities in Peripheral Artery Disease

Increase in antibiotic resistance in diabetic foot infections among peruvian patients: a single-center cross-sectional study

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