A review of current challenges and prospects of magnesium and its alloy for bone implant applications

Azadani, Meysam N.; Zahedi, S. Abolfazl; Bowoto, Oluwole K.; Oladapo, Bankole I.

doi:10.1007/s40204-022-00182-x

Cited by 77 publications

(38 citation statements)

References 178 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Finally, some concerns have been raised through the years that pneumarthrosis can be induced as a result of hydrogen production during the corrosion process [ 32 , 33 , 34 , 35 , 36 , 37 , 38 ]. As such, the synovial membrane can be furthermore damaged as a secondary effect to hydrogen accumulation [ 32 , 33 , 34 ].…”

Section: Resultsmentioning

confidence: 99%

In Vivo Study of Local and Systemic Responses to Clinical Use of Mg–1Ca Bioresorbable Orthopedic Implants

et al. 2022

View full text Add to dashboard Cite

(1) Background: Resorbable Mg-based implants represent a new direction in orthopedic surgery but have some drawbacks, such as their rapid biodegradation and increased rate of corrosion. Some in vitro studies hypothesized that tissue necrosis, incision dehiscence, risk of gas embolization in vital organs, interference with coagulation processes, and trophocyte viability impairment can occur. (2) Methods: We conducted an in vivo study on ten rabbit cases, in two groups; group one, consisting of six cases, received cylindrical implants of Mg–1Ca alloy in tibial intramedullary bone tissue. Group two, consisting of four cases, received Mg–1Ca parallelepiped implants, in the thigh muscular tissue. We recorded and compared weight (preoperatively and at 2, 4, and 6 weeks postoperatively), complete blood count, serum electrolytes, liver and kidney functional markers, and coagulation parameters, prior to and at 6 weeks after surgery. Local evolution was assessed radiologically and with tissue biopsies with complete pathology analysis. (3) Results: All biological markers and clinical evolution were favorable, showing good integration of the implants with none of the local or systemic signs of degradation. (4) Conclusions: Our study shows that the clinical use of Mg–1Ca bioresorbable alloys can be safe as none of the cited local or systemic complications have been identified.

show abstract

Section: Resultsmentioning

confidence: 99%

In Vivo Study of Local and Systemic Responses to Clinical Use of Mg–1Ca Bioresorbable Orthopedic Implants

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Numerous researchers have devoted extensive efforts to modulating the in vitro and in vivo AM Mg alloy degradation rate to address the long-term safety of porous scaffolds, accomplishing inspiring progress (Wang and Shi, 2011;Dutta et al, 2020;Nasr Azadani et al, 2022). Purification and alloying are two strategies used to address the rapid degradation of AM-Mg alloys.…”

Section: Typical Strategies To Improve the Corrosion Resistance Of Mg...mentioning

confidence: 99%

“…Surface modification affects the biodegradation rate of AM Mg alloys ( Matras, 2019 ). In response to the fast degradation rate, local alkalinization, and local gas emission of Mg alloys, a wide variety of surface modification approaches have been introduced to construct a corrosion barrier layer on the surface of the Mg alloy body to inhibit degradation ( Guo et al, 2022 ).…”

Section: Degradation Behavior and Typical Strategies To Enhance The C...mentioning

confidence: 99%

Comprehensive review of additively manufactured biodegradable magnesium implants for repairing bone defects from biomechanical and biodegradable perspectives

et al. 2022

View full text Add to dashboard Cite

Bone defect repair is a complicated clinical problem, particularly when the defect is relatively large and the bone is unable to repair itself. Magnesium and its alloys have been introduced as versatile biomaterials to repair bone defects because of their excellent biocompatibility, osteoconductivity, bone-mimicking biomechanical features, and non-toxic and biodegradable properties. Therefore, magnesium alloys have become a popular research topic in the field of implants to treat critical bone defects. This review explores the popular Mg alloy research topics in the field of bone defects. Bibliometric analyses demonstrate that the degradation control and mechanical properties of Mg alloys are the main research focus for the treatment of bone defects. Furthermore, the additive manufacturing (AM) of Mg alloys is a promising approach for treating bone defects using implants with customized structures and functions. This work reviews the state of research on AM-Mg alloys and the current challenges in the field, mainly from the two aspects of controlling the degradation rate and the fabrication of excellent mechanical properties. First, the advantages, current progress, and challenges of the AM of Mg alloys for further application are discussed. The main mechanisms that lead to the rapid degradation of AM-Mg are then highlighted. Next, the typical methods and processing parameters of laser powder bed fusion fabrication on the degradation characteristics of Mg alloys are reviewed. The following section discusses how the above factors affect the mechanical properties of AM-Mg and the recent research progress. Finally, the current status of research on AM-Mg for bone defects is summarized, and some research directions for AM-Mg to drive the application of clinical orthopedic implants are suggested.

show abstract

“…К магниевым каркасам с пористой структурой предъявляются повышенные требования по скорости деградации и механической прочности. Поэтому попрежнему существует необходимость в разработке новых типов каркасов на основе медицинского магниевого сплава для инженерии костной ткани [41].…”

Section: каркасы для инженерии костной тканиunclassified

Opportunities and Prospects for the Use of Magnesium-Containing Biomaterials in Orthopedics and Bone Tissue Engineering

Ananeva¹,

Baraeva²,

Bykov³

et al. 2022

СПНО (MPSE)

View full text Add to dashboard Cite

В представленном обзоре обсуждаются проблемы и перспективы ортопедических имплантатов на основе магния (Mg), а также текущее состояние и будущие направления исследований содержащих магний биоматериалов в ортопедии и инженерии костной ткани. Ортопедические имплантаты на основе магния могут быть многообещающими для лечения сложных заболеваний костей, что связано с их оптимальными механическими, остеотропными и антибактериальным свойствами. Магний и материалы на его основе широко изучались для процедур регенерации тканей в силу их уникальной биоразлагаемости. Цель данного обзора состояла в том, чтобы проанализировать и обсудить применение Mg и материалов на его основе в направленной костной регенерации. Ионы магния стимулируют остеогенез, что важно для заживления дефектов костной ткани. Костные имплантаты на его основе обеспечивают стабильную механическую поддержку на ранней стадии имплантации и постепенно деградируют с восстановлением дефекта костной ткани, выполняя свое клиническое назначение в качестве временных устройств фиксации кости или каркасов для инженерии костной ткани. Инновационные стратегии, позволяющие регулировать скорость деградации имплантата в соответствии со скоростью заживления костной ткани, а также гибридные системы имплантов, сочетающие содержащие магний биоматериалы, способствующие регенерации кости, с металлами (титан, сталь), которые обеспечивают прочную фиксацию костных структур в участках скелета с высокой нагрузкой, обсуждаются для устранения ограничений использования биоматериалов на основе магния в целях их клинического применения. Ключевые слова: магний, костный имплантат, биосовместимость, остеогенез, магниевый сплав.

show abstract

A review of current challenges and prospects of magnesium and its alloy for bone implant applications

Cited by 77 publications

References 178 publications

In Vivo Study of Local and Systemic Responses to Clinical Use of Mg–1Ca Bioresorbable Orthopedic Implants

In Vivo Study of Local and Systemic Responses to Clinical Use of Mg–1Ca Bioresorbable Orthopedic Implants

Comprehensive review of additively manufactured biodegradable magnesium implants for repairing bone defects from biomechanical and biodegradable perspectives

Opportunities and Prospects for the Use of Magnesium-Containing Biomaterials in Orthopedics and Bone Tissue Engineering

Contact Info

Product

Resources

About