A review of current antibiotic resistance and promising antibiotics with novel modes of action to combat antibiotic resistance

Chen, Lei; Kumar, Suresh; Wu, Hongyan

doi:10.1007/s00203-023-03699-2

Cited by 12 publications

(2 citation statements)

References 79 publications

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“…The amount of PHMB released was quantified using a UV spectrophotometer at a wavelength of 236 nm. Absorbance (Y) was proportional to the concentration of PHMB (x) and was calculated using the Equation (2).…”

Section: Loading and Release Behavior Of Cmc-phmb/gp And Pul-phmb/gpmentioning

confidence: 99%

“…Bacterial infections pose a significant threat to healthcare, necessitating vigilant attention and innovative solutions. Antibiotics have long been the cornerstone of bacterial infection management; however, the emergence of antibiotic resistance has exposed the fragility of this approach [1][2][3]. Thus, it becomes paramount to explore alternative methods for curbing bacterial proliferation [4].…”

Section: Introductionmentioning

confidence: 99%

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Development and Evaluation of a Novel Antibacterial Wound Dressing: A Powder Preparation Based on Cross-Linked Pullulan with Polyhexamethylene Biguanide for Hydrogel-Transition in Advanced Wound Management and Infection Control

Su,

Yu,

Guo

et al. 2024

Polymers

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As antibiotic resistance increasingly undermines traditional infection management strategies, there is a critical demand for innovative wound care solutions that address these emerging challenges. This study introduces a novel antibacterial wound dressing based on Cross-Linked Pullulan (Pul) and Polyhexamethylene Biguanide (PHMB) for enhanced wound management and infection control. The dressing’s adsorption rate reached 200% of its original weight within 30 min, exceeded 300% after 5 h, and exhibited significant non-Newtonian fluid properties. The dressings were able to release the loaded medication completely within 20 min; additionally, the dressing demonstrated significant antibacterial activity against a broad spectrum of bacteria. Significantly, the therapeutic effects of the Pul-PHMB/GP dressing were evaluated in a mouse model. Compared to untreated wounds, wounds treated with Pul-PHMB/GP exhibited a significant gelation process within 5 min post-treatment and showed a significant increase in wound healing rate within 12 days. This powder preparation overcomes the limitations associated with liquid and gel dressings, notably in storage and precise application, preventing the premature expansion or dissolution often caused by PHMB in high-humidity environments. The powder form can transform into a gel upon contact with wound exudate, ensuring accurate coverage of irregular wounds, such as those from burns or pressure sores, and offers excellent chemical and physical stability in a dry state, which facilitates storage and transport. This makes the dressing particularly suitable for emergency medical care and precision therapy, significantly improving the efficiency and adaptability of wound treatment and providing robust support for clinical treatments and emergency responses.

show abstract

Section: Loading and Release Behavior Of Cmc-phmb/gp And Pul-phmb/gpmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Development and Evaluation of a Novel Antibacterial Wound Dressing: A Powder Preparation Based on Cross-Linked Pullulan with Polyhexamethylene Biguanide for Hydrogel-Transition in Advanced Wound Management and Infection Control

Su,

Yu,

Guo

et al. 2024

Polymers

View full text Add to dashboard Cite

show abstract

Screening of promising molecules against potential drug targets in Yersinia pestis by integrative pan and subtractive genomics, docking and simulation approach

Chen,

Zhang,

et al. 2024

Arch Microbiol

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Hydrazyl hydroxycoumarins as new potential conquerors towards Pseudomonas aeruginosa

Zhao,

Ahmad,

et al. 2024

Bioorganic & Medicinal Chemistry Letters

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A review of current antibiotic resistance and promising antibiotics with novel modes of action to combat antibiotic resistance

Cited by 12 publications

References 79 publications

Development and Evaluation of a Novel Antibacterial Wound Dressing: A Powder Preparation Based on Cross-Linked Pullulan with Polyhexamethylene Biguanide for Hydrogel-Transition in Advanced Wound Management and Infection Control

Development and Evaluation of a Novel Antibacterial Wound Dressing: A Powder Preparation Based on Cross-Linked Pullulan with Polyhexamethylene Biguanide for Hydrogel-Transition in Advanced Wound Management and Infection Control

Screening of promising molecules against potential drug targets in Yersinia pestis by integrative pan and subtractive genomics, docking and simulation approach

Hydrazyl hydroxycoumarins as new potential conquerors towards Pseudomonas aeruginosa

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